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RECRUITING Phase 1

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

NCT04900818 · View on ClinicalTrials.gov ↗

Study Summary

This is an open label, multi-center, multiple dose Phase 1 study to evaluate the safety, tolerability, MTD PK, and PD of TJ033721 (givastomig) in subjects with advanced or metastatic solid tumors.

Interventions

  • DRUG TJ033721 (givastomig)
  • DRUG TJ033721 (givastomig) , nivolumab, chemotherapy
  • DRUG TJ033721 (givastomig), chemotherapy
  • DRUG TJ033721 (givastomig), durvalumab, chemotherapy

Study Locations (20)

New York

  • NYU Langone — New York
  • Memorial Sloan Kettering Cancer Center — New York

California

  • Stern Center for Cancer Clinical Trials and Research — Orange

Colorado

  • UCHealth Cancer Care - Anschutz Medical Campus — Aurora

Indiana

  • Horizon Oncology Research, LLC. — Layfayette

Massachusetts

  • Mass General Hospital — Boston

New Jersey

  • Rutgers Cancer Institute of New Jersey — New Brunswick

North Carolina

  • Carolina BioOncology Institute — Huntersville

Tennessee

  • Vanderbilt-Ingram Cancer Center — Nashville

Trial Details

FieldValue
Enrollment Target 330 participants
Start Date 2021-06-29
Est. Completion 2027-12
Phase Phase 1

Sponsor

I-Mab Biopharma US Limited

29 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04900818

The ClinicalTrials.gov registry entry for NCT04900818 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 330 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is I-Mab Biopharma US Limited, which has 29 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Solid Tumor appearing as the primary indexed condition, and to 4 interventions — of which TJ033721 (givastomig) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04900818 reports 20 study locations spanning 19 distinct geographic areas — top geographies include New York, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04900818 about?

NCT04900818 is a clinical study titled "Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors". This is an open label, multi-center, multiple dose Phase 1 study to evaluate the safety, tolerability, MTD PK, and PD of TJ033721 (givastomig) in subjects with advanced or metastatic solid tumors.

What is the current status of trial NCT04900818?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 330 participants. The study started on 2021-06-29. Estimated completion is 2027-12.

What conditions does trial NCT04900818 study?

This clinical trial studies the following conditions: Solid Tumor, Gastric Cancer, Advanced Cancer, Metastatic Cancer, Esophageal Adenocarcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04900818?

The interventions under investigation include: TJ033721 (givastomig) (DRUG), TJ033721 (givastomig) , nivolumab, chemotherapy (DRUG), TJ033721 (givastomig), chemotherapy (DRUG), TJ033721 (givastomig), durvalumab, chemotherapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04900818?

This trial is sponsored by I-Mab Biopharma US Limited, which has 29 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04900818 being conducted?

This trial has 20 study locations across California, Colorado, Indiana, Massachusetts, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial