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RECRUITING Phase 2

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

NCT05686226 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase II clinical trial to assess the clinical activity of immunotherapy with E7 TCR-T cells for metastatic HPV-associated cancers. HPV-associated cancers in include cervical, throat, penile, vulvar, vaginal, anal, and other cancers. Participants will receive a conditioning regimen, E7 TCR-T cells, and aldesleukin. Clinical response to treatment will be determined.

Interventions

  • DRUG Aldesleukin
  • BIOLOGICAL E7 TCR-T cells

Study Locations (3)

New Jersey

  • Rutgers Cancer Institute — New Brunswick
  • RWJBarnabas Health - Robert Wood Johnson University Hospital — New Brunswick

Maryland

  • National Institutes of Health Clinical Center — Bethesda

Trial Details

FieldValue
Enrollment Target 20 participants
Start Date 2023-03-07
Est. Completion 2027-01-01
Phase Phase 2

Sponsor

Christian Hinrichs

34 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05686226

The ClinicalTrials.gov registry entry for NCT05686226 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Christian Hinrichs, which has 34 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 10 conditions, with Cervical Cancer appearing as the primary indexed condition, and to 2 interventions — of which Aldesleukin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05686226 reports 3 study locations spanning 2 distinct geographic areas — top geographies include New Jersey, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05686226 about?

NCT05686226 is a clinical study titled "E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers". This is a phase II clinical trial to assess the clinical activity of immunotherapy with E7 TCR-T cells for metastatic HPV-associated cancers. HPV-associated cancers in include cervical, throat, penile, vulvar, vaginal, anal, and other cancers. Participants will receive a conditioning regimen, E7 TCR...

What is the current status of trial NCT05686226?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 20 participants. The study started on 2023-03-07. Estimated completion is 2027-01-01.

What conditions does trial NCT05686226 study?

This clinical trial studies the following conditions: Cervical Cancer, Metastatic Cancer, Oropharynx Cancer, Anal Cancer, Vaginal Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05686226?

The interventions under investigation include: Aldesleukin (DRUG), E7 TCR-T cells (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05686226?

This trial is sponsored by Christian Hinrichs, which has 34 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05686226 being conducted?

This trial has 3 study locations across Maryland, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial