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ClinicalTrials.gov 74 recruiting now official registry

Metastatic Breast Cancer clinical trials

74 of 140 indexed Metastatic Breast Cancer trials are currently recruiting.

140 US clinical trials · 74 currently recruiting

Metastatic Breast Cancer is the subject of 140 registered US clinical trials on ClinicalTrials.gov, 74 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 99 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 12 of these trials.

The research picture

Metastatic Breast Cancer has 140 registered US clinical trials, 74 of them open to new participants right now, about 53% of the total.

74
recruiting participants now
53%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
12
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 147Phase 252Phase 310Phase 41

Active & Recent Trials

140 total, page 3 of 3

ACTIVE NOT RECRUITING Phase 1 20 participants

PVX-410 Vaccine Plus Pembrolizumab in HLA-A2+ Metastatic Triple Negative Breast Cancer

Massachusetts General Hospital

NCT03362060

ACTIVE NOT RECRUITING Phase 1 16 participants

Trial of 225Ac-DOTATATE (RYZ101) in Subjects With ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs.

RayzeBio

NCT06590857

ACTIVE NOT RECRUITING Phase 2 15 participants

Preventing High Blood Sugar in People Being Treated for Metastatic Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT05090358

ACTIVE NOT RECRUITING 15 participants

Utilizing Continuous Glucose Monitoring to Characterize and Manage Hyperglycemia in Patients Initiating Alpelisib

HealthPartners Institute

NCT06083038

ACTIVE NOT RECRUITING Phase 2 9 participants

A Study of Tucatinib Given Before Surgery to People With HER2+ Cancers That Have Spread to the Brain

Memorial Sloan Kettering Cancer Center

NCT05892068

COMPLETED Phase 3 513 participants

A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer

AbbVie

NCT02163694

COMPLETED Phase 2 349 participants

Trial of Active Immunotherapy With Globo H-KLH (OPT-822) in Metastatic Breast Cancer Subjects

OBI Pharma

NCT01516307

COMPLETED Phase 2 194 participants

A Double-blind Study of Paclitaxel in Combination With Reparixin or Placebo for Metastatic Triple-Negative Breast Cancer

Dompé Farmaceutici S.p.A

NCT02370238

COMPLETED 194 participants

Observational Retrospective Study to Assess the Use of Ribociclib in Patients With HR+, HER2- Metastatic Breast Cancer Treated With Chemotherapy

Novartis Pharmaceuticals

NCT06619704

COMPLETED Phase 2 176 participants

Phase II Trial of Weekly or Every 3-week Ixabepilone for Patients With Metastatic Breast Cancer

R-Pharm

NCT00593827

COMPLETED Phase 2 131 participants

Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AI

PrECOG

NCT01797120

COMPLETED Phase 2 127 participants

Trial of Eribulin in Patients Who Do Not Achieve Pathologic Complete Response (pCR) Following Neoadjuvant Chemotherapy

SCRI Development Innovations

NCT01401959

COMPLETED NA 120 participants

Palliative and Oncology Care Model in Breast Cancer

Massachusetts General Hospital

NCT02730858

COMPLETED Phase 1 120 participants

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Novartis Pharmaceuticals

NCT01576666

COMPLETED Phase 2 72 participants

A Phase II Trial of Abraxane™ Given Weekly as a Single Agent in First-line Treatment of Metastatic Breast Cancer

Veeda Oncology

NCT00251472

COMPLETED Phase 2 71 participants

Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer

SCRI Development Innovations

NCT00894504

COMPLETED Phase 1 68 participants

Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer

Otto Metzger, MD

NCT02390427

COMPLETED 48 participants

Interview of Patients With HR+/HER2- Metastatic Breast Cancer Who Received Capivasertib + Fulvestrant

AstraZeneca

NCT07008963

COMPLETED Phase 2 43 participants

Safety, Feasibility and Efficacy of Vitamin D Supplementation in Women With Metastatic Breast Cancer (SAFE-D)

Loyola University

NCT02186015

COMPLETED NA 42 participants

Nurse AMIE for Echo Show: Randomized Control Trial

Milton S. Hershey Medical Center

NCT04673019

COMPLETED Phase 2 41 participants

Phase II Trial of Capecitabine With Fulvestrant for Postmenopausal Women With Hormone Receptor Positive Metastatic Breast Cancer

Accelerated Community Oncology Research Network

NCT00534417

COMPLETED Phase 1 41 participants

First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors

Relay Therapeutics

NCT05759949

COMPLETED Phase 2 39 participants

A Study of LY2523355 in Participants With Breast Cancer

Eli Lilly and Company

NCT01416389

COMPLETED 33 participants

Treatment Patterns and Clinical Outcomes Among Talazoparib-Treated Adults With HER2-Negative mBC With gBRCA1/2m

Pfizer

NCT05141708

COMPLETED Phase 1 33 participants

Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC)

Dompé Farmaceutici S.p.A

NCT02001974

COMPLETED NA 32 participants

IMAGE Study: Personalized Molecular Profiling in Cancer Treatment at Johns Hopkins

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01939847

COMPLETED Phase 2 30 participants

Study of Avastin (Bevacizumab) to Reverse Acquired Estrogen Independence in Previously Hormone Responsive Metastatic Breast Ca.

University of Alabama at Birmingham

NCT00240071

COMPLETED NA 28 participants

Utilizing Multiomic Advanced Diagnostics to Identify CDK 4/6 Inhibitor Response Predictors and a Post-treatment Multiomic Signature for Patients With ER+/HER2- Metastatic Breast Cancer

Side-Out Foundation

NCT03195192

COMPLETED NA 27 participants

Aerobic Training in Metastatic Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT01725633

COMPLETED Phase 2 25 participants

Capecitabine and Oxaliplatin in Treating Patients With Metastatic Breast Cancer

Hoosier Cancer Research Network

NCT00216021

COMPLETED Phase 1 24 participants

T-DM1 With Abraxane and Lapatinib for Metastatic HER2 Positive Breast Cancer

Jenny C. Chang, MD

NCT02073916

COMPLETED Phase 2 21 participants

Intensive Combo Chemo With Autologous BM Rescue for Metastatic Breast Cancer

University of Oklahoma

NCT00584766

COMPLETED Phase 1 20 participants

A Study of MM-111 in Patients With Advanced, Refractory Her2 Amplified, Heregulin Positive Cancers

Merrimack Pharmaceuticals

NCT00911898

COMPLETED Phase 2 19 participants

ER Reactivation Therapy for Breast Cancer

Dartmouth-Hitchcock Medical Center

NCT02188745

COMPLETED Phase 1 19 participants

Open Label Dose-Finding Study of TRC105 Plus Capecitabine for Metastatic Breast Cancer

Tracon Pharmaceuticals

NCT01326481

COMPLETED Phase 1 17 participants

ACY-1215 + Nab-paclitaxel in Metastatic Breast Cancer

Columbia University

NCT02632071

COMPLETED Phase 1 14 participants

Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases

H. Lee Moffitt Cancer Center and Research Institute

NCT03807765

COMPLETED Phase 1 9 participants

HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer

Abramson Cancer Center at Penn Medicine

NCT03685331

COMPLETED Phase 2 9 participants

Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate

Case Comprehensive Cancer Center

NCT02581839

COMPLETED Phase 1 6 participants

cMet CAR RNA T Cells Targeting Breast Cancer

University of Pennsylvania

NCT01837602

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 52
Phase 3 10
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Breast Cancer Trial Landscape

140 indexed Metastatic Breast Cancer studies · 74 recruiting (53%).

Phase mix: 11 late (III/IV) vs 99 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (12 trials), 9 others listed. 40 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Breast Cancer?

PlainTrial tracks 140 US clinical trials for Metastatic Breast Cancer, of which 74 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Breast Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.