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Metastatic Breast Cancer clinical trials
74 of 140 indexed Metastatic Breast Cancer trials are currently recruiting.
140 US clinical trials · 74 currently recruiting
Metastatic Breast Cancer is the subject of 140 registered US clinical trials on ClinicalTrials.gov, 74 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 99 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 12 of these trials.
The research picture
Metastatic Breast Cancer has 140 registered US clinical trials, 74 of them open to new participants right now, about 53% of the total.
- 74
- recruiting participants now
- 53%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 12
- top sponsor: Memorial Sloan Kettering Cancer Center
Active & Recent Trials
140 total, page 3 of 3
PVX-410 Vaccine Plus Pembrolizumab in HLA-A2+ Metastatic Triple Negative Breast Cancer
Massachusetts General Hospital
NCT03362060
Trial of 225Ac-DOTATATE (RYZ101) in Subjects With ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs.
RayzeBio
NCT06590857
Preventing High Blood Sugar in People Being Treated for Metastatic Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT05090358
Utilizing Continuous Glucose Monitoring to Characterize and Manage Hyperglycemia in Patients Initiating Alpelisib
HealthPartners Institute
NCT06083038
A Study of Tucatinib Given Before Surgery to People With HER2+ Cancers That Have Spread to the Brain
Memorial Sloan Kettering Cancer Center
NCT05892068
A Phase 3 Randomized, Placebo-controlled Trial of Carboplatin and Paclitaxel With or Without Veliparib (ABT-888) in HER2-negative Metastatic or Locally Advanced Unresectable BRCA-associated Breast Cancer
AbbVie
NCT02163694
Trial of Active Immunotherapy With Globo H-KLH (OPT-822) in Metastatic Breast Cancer Subjects
OBI Pharma
NCT01516307
A Double-blind Study of Paclitaxel in Combination With Reparixin or Placebo for Metastatic Triple-Negative Breast Cancer
Dompé Farmaceutici S.p.A
NCT02370238
Observational Retrospective Study to Assess the Use of Ribociclib in Patients With HR+, HER2- Metastatic Breast Cancer Treated With Chemotherapy
Novartis Pharmaceuticals
NCT06619704
Phase II Trial of Weekly or Every 3-week Ixabepilone for Patients With Metastatic Breast Cancer
R-Pharm
NCT00593827
Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AI
PrECOG
NCT01797120
Trial of Eribulin in Patients Who Do Not Achieve Pathologic Complete Response (pCR) Following Neoadjuvant Chemotherapy
SCRI Development Innovations
NCT01401959
Palliative and Oncology Care Model in Breast Cancer
Massachusetts General Hospital
NCT02730858
Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors
Novartis Pharmaceuticals
NCT01576666
A Phase II Trial of Abraxane™ Given Weekly as a Single Agent in First-line Treatment of Metastatic Breast Cancer
Veeda Oncology
NCT00251472
Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer
SCRI Development Innovations
NCT00894504
Phase Ib Dose-escalation Trial of Taselisib (GDC-0032) in Combination With Anti-HER2 Therapies in Participants With Advanced HER2+ Breast Cancer
Otto Metzger, MD
NCT02390427
Interview of Patients With HR+/HER2- Metastatic Breast Cancer Who Received Capivasertib + Fulvestrant
AstraZeneca
NCT07008963
Safety, Feasibility and Efficacy of Vitamin D Supplementation in Women With Metastatic Breast Cancer (SAFE-D)
Loyola University
NCT02186015
Nurse AMIE for Echo Show: Randomized Control Trial
Milton S. Hershey Medical Center
NCT04673019
Phase II Trial of Capecitabine With Fulvestrant for Postmenopausal Women With Hormone Receptor Positive Metastatic Breast Cancer
Accelerated Community Oncology Research Network
NCT00534417
First-in-Human Study of RLY-5836 in Advanced Breast Cancer and Other Solid Tumors
Relay Therapeutics
NCT05759949
A Study of LY2523355 in Participants With Breast Cancer
Eli Lilly and Company
NCT01416389
Treatment Patterns and Clinical Outcomes Among Talazoparib-Treated Adults With HER2-Negative mBC With gBRCA1/2m
Pfizer
NCT05141708
Pilot Study to Evaluate Reparixin With Weekly Paclitaxel in Patients With HER 2 Negative Metastatic Breast Cancer (MBC)
Dompé Farmaceutici S.p.A
NCT02001974
IMAGE Study: Personalized Molecular Profiling in Cancer Treatment at Johns Hopkins
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT01939847
Study of Avastin (Bevacizumab) to Reverse Acquired Estrogen Independence in Previously Hormone Responsive Metastatic Breast Ca.
University of Alabama at Birmingham
NCT00240071
Utilizing Multiomic Advanced Diagnostics to Identify CDK 4/6 Inhibitor Response Predictors and a Post-treatment Multiomic Signature for Patients With ER+/HER2- Metastatic Breast Cancer
Side-Out Foundation
NCT03195192
Aerobic Training in Metastatic Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT01725633
Capecitabine and Oxaliplatin in Treating Patients With Metastatic Breast Cancer
Hoosier Cancer Research Network
NCT00216021
T-DM1 With Abraxane and Lapatinib for Metastatic HER2 Positive Breast Cancer
Jenny C. Chang, MD
NCT02073916
Intensive Combo Chemo With Autologous BM Rescue for Metastatic Breast Cancer
University of Oklahoma
NCT00584766
A Study of MM-111 in Patients With Advanced, Refractory Her2 Amplified, Heregulin Positive Cancers
Merrimack Pharmaceuticals
NCT00911898
ER Reactivation Therapy for Breast Cancer
Dartmouth-Hitchcock Medical Center
NCT02188745
Open Label Dose-Finding Study of TRC105 Plus Capecitabine for Metastatic Breast Cancer
Tracon Pharmaceuticals
NCT01326481
ACY-1215 + Nab-paclitaxel in Metastatic Breast Cancer
Columbia University
NCT02632071
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
H. Lee Moffitt Cancer Center and Research Institute
NCT03807765
HOPE: Olaparib, Palbociclib and Fulvestrant in Patients With BRCA Mutation-associated, HR+, HER2-metastatic Breast Cancer
Abramson Cancer Center at Penn Medicine
NCT03685331
Treatment of Brain Metastases From Breast Cancer With Eribulin Mesylate
Case Comprehensive Cancer Center
NCT02581839
cMet CAR RNA T Cells Targeting Breast Cancer
University of Pennsylvania
NCT01837602
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 47 |
| Phase 2 | 52 |
| Phase 3 | 10 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Metastatic Breast Cancer Trial Landscape
140 indexed Metastatic Breast Cancer studies · 74 recruiting (53%).
Phase mix: 11 late (III/IV) vs 99 early (I/II).
Top sponsor: Memorial Sloan Kettering Cancer Center (12 trials), 9 others listed. 40 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Metastatic Breast Cancer?
PlainTrial tracks 140 US clinical trials for Metastatic Breast Cancer, of which 74 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Metastatic Breast Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.