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ClinicalTrials.gov 74 recruiting now official registry

Metastatic Breast Cancer clinical trials

74 of 140 indexed Metastatic Breast Cancer trials are currently recruiting.

140 US clinical trials · 74 currently recruiting

Metastatic Breast Cancer is the subject of 140 registered US clinical trials on ClinicalTrials.gov, 74 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 99 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 12 of these trials.

The research picture

Metastatic Breast Cancer has 140 registered US clinical trials, 74 of them open to new participants right now, about 53% of the total.

74
recruiting participants now
53%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
12
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 147Phase 252Phase 310Phase 41

Active & Recent Trials

140 total, page 2 of 3

RECRUITING NA 45 participants

Primary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy

Mayo Clinic

NCT06055881

RECRUITING Phase 1 42 participants

HER-2 B Cell Peptide Vaccine

Pravin T.P Kaumaya

NCT06414733

RECRUITING Phase 1 41 participants

Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients

Weill Medical College of Cornell University

NCT03449238

RECRUITING NA 40 participants

Adaptation of a Values Assessment Tool

UNC Lineberger Comprehensive Cancer Center

NCT07068477

RECRUITING Phase 2 40 participants

A Study on Adding Precisely Targeted Radiation Therapy (Stereotactic Body Radiation Therapy) to the Usual Treatment Approach (Drug Therapy) in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT05534438

RECRUITING Phase 2 40 participants

Phase II Single Arm Trial of Low Dose Capecitabine in Patients With Advanced Breast Cancer

University of Alabama at Birmingham

NCT06105684

RECRUITING Phase 2 36 participants

STUDY02001740;22SCH740: Estradiol For ER+ Advanced Breast Cancer (ESTHER)

Dartmouth-Hitchcock Medical Center

NCT05716516

RECRUITING Phase 2 36 participants

Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)

The Methodist Hospital Research Institute

NCT05660083

RECRUITING Phase 2 35 participants

Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer

Mayo Clinic

NCT06525766

RECRUITING Phase 1 34 participants

Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent Ovarian Cancer w Response Prediction By Genomics

University of Utah

NCT04315233

RECRUITING Phase 2 34 participants

A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT04683679

RECRUITING Phase 1 30 participants

CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

University of Texas Southwestern Medical Center

NCT05029999

RECRUITING Phase 1 30 participants

A Study of Pembrolizumab and Cryoablation in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06246968

RECRUITING 30 participants

A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06557148

RECRUITING Phase 1 28 participants

A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06678269

RECRUITING Phase 2 26 participants

Definitive Radiation for High-Risk Spine Metastases

Stony Brook University

NCT06165419

RECRUITING Phase 2 20 participants

Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer

University of California, Irvine

NCT05524584

RECRUITING Phase 2 16 participants

Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis

Wake Forest University Health Sciences

NCT02422641

RECRUITING Phase 2 15 participants

Sequential Therapies Modeled on Evolutionary Dynamics for Breast Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT06409390

RECRUITING 15 participants

Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians

UNC Lineberger Comprehensive Cancer Center

NCT05440929

RECRUITING Phase 2 15 participants

Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer

University of Louisville

NCT04990921

RECRUITING Phase 2 13 participants

Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer

University of Wisconsin, Madison

NCT04573231

RECRUITING 12 participants

Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)

University of California, San Francisco

NCT05964504

RECRUITING Phase 1 6 participants

Estradiol Plus Olaparib for Breast Cancer (PHOEBE)

Mary D Chamberlin

NCT05900895

ACTIVE NOT RECRUITING 7,933 participants

Real-World Treatment Patterns and Outcomes in HER2-Altered Metastatic Breast Cancer Patients in the United States

Boehringer Ingelheim

NCT07342309

ACTIVE NOT RECRUITING Phase 3 541 participants

A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)

DualityBio

NCT06018337

ACTIVE NOT RECRUITING Phase 1 500 participants

A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer

Eli Lilly and Company

NCT04188548

ACTIVE NOT RECRUITING Phase 3 456 participants

Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype

SOLTI Breast Cancer Research Group

NCT05207709

ACTIVE NOT RECRUITING Phase 1 245 participants

A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer

AstraZeneca

NCT04538742

ACTIVE NOT RECRUITING Phase 2 234 participants

A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer

Eli Lilly and Company

NCT02747004

ACTIVE NOT RECRUITING Phase 2 220 participants

Palbociclib After CDK and Endocrine Therapy (PACE)

Dana-Farber Cancer Institute

NCT03147287

ACTIVE NOT RECRUITING NA 200 participants

Personalized Molecular Profiling in Cancer Treatment at Johns Hopkins

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02965755

ACTIVE NOT RECRUITING Phase 2 154 participants

PhII ICb With/Without Erbitux in MBC Pts

US Oncology Research

NCT00248287

ACTIVE NOT RECRUITING Phase 1 138 participants

A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer

AstraZeneca

NCT04556773

ACTIVE NOT RECRUITING Phase 4 134 participants

Roll-over Study to Allow Continued Access to Ribociclib

Novartis Pharmaceuticals

NCT05161195

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 2 114 participants

Olaparib In Metastatic Breast Cancer

Beth Israel Deaconess Medical Center

NCT03344965

ACTIVE NOT RECRUITING NA 110 participants

Couples' QOL in Metastatic Breast Cancer

Fox Chase Cancer Center

NCT05636943

ACTIVE NOT RECRUITING Phase 2 110 participants

Sacituzumab Govitecan +/- Pembrolizumab In HR+ / HER2 - MBC

Ana C Garrido-Castro, MD

NCT04448886

ACTIVE NOT RECRUITING Phase 2 82 participants

STOP-HER2: Stopping Trastuzumab in HER2+ MBC

Dana-Farber Cancer Institute

NCT05721248

ACTIVE NOT RECRUITING 78 participants

Assessing the Time Demands of Cancer

Masonic Cancer Center, University of Minnesota

NCT05708703

ACTIVE NOT RECRUITING 65 participants

ACT-MBC: A Study of Circulating Tumor Cells (CTCs) in Metastatic Breast Cancer (MBC)

Menarini Silicon Biosystems

NCT05662345

ACTIVE NOT RECRUITING Phase 2 61 participants

ELACESTRANT in Women and Men With CDK4/6 Inhibitor-Naive Estrogen Receptor Positive, HER-2 Negative Metastatic Breast Cancer Study

Stemline Therapeutics

NCT05596409

ACTIVE NOT RECRUITING Phase 2 60 participants

Palbociclib With Fulvestrant for Metastatic Breast Cancer After Treatment With Palbociclib and an Aromatase Inhibitor

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT02738866

ACTIVE NOT RECRUITING Phase 1 50 participants

Onvansertib + Paclitaxel In TNBC

Antonio Giordano, MD

NCT05383196

ACTIVE NOT RECRUITING Phase 1 46 participants

Niraparib in Combination With Trastuzumab in Metastatic HER2+ Breast Cancer

University of Alabama at Birmingham

NCT03368729

ACTIVE NOT RECRUITING Phase 1 30 participants

Towards Understanding Between ADT Treatment, Circadian Rhythm, and Physiological Responsiveness

University of Maryland, Baltimore

NCT05968144

ACTIVE NOT RECRUITING Phase 2 24 participants

Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast Cancer

University of Miami

NCT05826964

ACTIVE NOT RECRUITING Phase 1 22 participants

Her2-BATS and Pembrolizumab in Metastatic Breast Cancer

University of Virginia

NCT03272334

ACTIVE NOT RECRUITING Phase 1 20 participants

[18F]FLT PET/CT in Rb+ Metastatic Breast Cancer

University of Pennsylvania

NCT02608216

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 52
Phase 3 10
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Breast Cancer Trial Landscape

140 indexed Metastatic Breast Cancer studies · 74 recruiting (53%).

Phase mix: 11 late (III/IV) vs 99 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (12 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Breast Cancer?

PlainTrial tracks 140 US clinical trials for Metastatic Breast Cancer, of which 74 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Breast Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.