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Metastatic Breast Cancer clinical trials
74 of 140 indexed Metastatic Breast Cancer trials are currently recruiting.
140 US clinical trials · 74 currently recruiting
Metastatic Breast Cancer is the subject of 140 registered US clinical trials on ClinicalTrials.gov, 74 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 99 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 12 of these trials.
The research picture
Metastatic Breast Cancer has 140 registered US clinical trials, 74 of them open to new participants right now, about 53% of the total.
- 74
- recruiting participants now
- 53%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 12
- top sponsor: Memorial Sloan Kettering Cancer Center
Active & Recent Trials
140 total, page 2 of 3
Primary Breast Oligoprogressive Sites Treated With Radiotherapy to Obviate the Need to Change Systemic Therapy
Mayo Clinic
NCT06055881
HER-2 B Cell Peptide Vaccine
Pravin T.P Kaumaya
NCT06414733
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
Weill Medical College of Cornell University
NCT03449238
Adaptation of a Values Assessment Tool
UNC Lineberger Comprehensive Cancer Center
NCT07068477
A Study on Adding Precisely Targeted Radiation Therapy (Stereotactic Body Radiation Therapy) to the Usual Treatment Approach (Drug Therapy) in People With Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT05534438
Phase II Single Arm Trial of Low Dose Capecitabine in Patients With Advanced Breast Cancer
University of Alabama at Birmingham
NCT06105684
STUDY02001740;22SCH740: Estradiol For ER+ Advanced Breast Cancer (ESTHER)
Dartmouth-Hitchcock Medical Center
NCT05716516
Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)
The Methodist Hospital Research Institute
NCT05660083
Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer
Mayo Clinic
NCT06525766
Ribociclib&Belinostat In Patients w Metastatic Triple Neg Breast Cancer & Recurrent Ovarian Cancer w Response Prediction By Genomics
University of Utah
NCT04315233
A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT04683679
CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer
University of Texas Southwestern Medical Center
NCT05029999
A Study of Pembrolizumab and Cryoablation in People With Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06246968
A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06557148
A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06678269
Definitive Radiation for High-Risk Spine Metastases
Stony Brook University
NCT06165419
Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer
University of California, Irvine
NCT05524584
Prospective Evaluation Of High-Dose Systemic Methotrexate In Patients With Breast Cancer And Leptomeningeal Metastasis
Wake Forest University Health Sciences
NCT02422641
Sequential Therapies Modeled on Evolutionary Dynamics for Breast Cancer
H. Lee Moffitt Cancer Center and Research Institute
NCT06409390
Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians
UNC Lineberger Comprehensive Cancer Center
NCT05440929
Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer
University of Louisville
NCT04990921
Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer
University of Wisconsin, Madison
NCT04573231
Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)
University of California, San Francisco
NCT05964504
Estradiol Plus Olaparib for Breast Cancer (PHOEBE)
Mary D Chamberlin
NCT05900895
Real-World Treatment Patterns and Outcomes in HER2-Altered Metastatic Breast Cancer Patients in the United States
Boehringer Ingelheim
NCT07342309
A Study of DB-1303/BNT323 vs Investigator's Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)
DualityBio
NCT06018337
A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer
Eli Lilly and Company
NCT04188548
Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype
SOLTI Breast Cancer Research Group
NCT05207709
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
AstraZeneca
NCT04538742
A Study of Abemaciclib (LY2835219) Plus Tamoxifen or Abemaciclib Alone in Women With Metastatic Breast Cancer
Eli Lilly and Company
NCT02747004
Palbociclib After CDK and Endocrine Therapy (PACE)
Dana-Farber Cancer Institute
NCT03147287
Personalized Molecular Profiling in Cancer Treatment at Johns Hopkins
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02965755
PhII ICb With/Without Erbitux in MBC Pts
US Oncology Research
NCT00248287
A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer
AstraZeneca
NCT04556773
Roll-over Study to Allow Continued Access to Ribociclib
Novartis Pharmaceuticals
NCT05161195
A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors
Sapience Therapeutics
NCT04478279
Olaparib In Metastatic Breast Cancer
Beth Israel Deaconess Medical Center
NCT03344965
Couples' QOL in Metastatic Breast Cancer
Fox Chase Cancer Center
NCT05636943
Sacituzumab Govitecan +/- Pembrolizumab In HR+ / HER2 - MBC
Ana C Garrido-Castro, MD
NCT04448886
STOP-HER2: Stopping Trastuzumab in HER2+ MBC
Dana-Farber Cancer Institute
NCT05721248
Assessing the Time Demands of Cancer
Masonic Cancer Center, University of Minnesota
NCT05708703
ACT-MBC: A Study of Circulating Tumor Cells (CTCs) in Metastatic Breast Cancer (MBC)
Menarini Silicon Biosystems
NCT05662345
ELACESTRANT in Women and Men With CDK4/6 Inhibitor-Naive Estrogen Receptor Positive, HER-2 Negative Metastatic Breast Cancer Study
Stemline Therapeutics
NCT05596409
Palbociclib With Fulvestrant for Metastatic Breast Cancer After Treatment With Palbociclib and an Aromatase Inhibitor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT02738866
Onvansertib + Paclitaxel In TNBC
Antonio Giordano, MD
NCT05383196
Niraparib in Combination With Trastuzumab in Metastatic HER2+ Breast Cancer
University of Alabama at Birmingham
NCT03368729
Towards Understanding Between ADT Treatment, Circadian Rhythm, and Physiological Responsiveness
University of Maryland, Baltimore
NCT05968144
Levels of Circulating Tumor DNA as a Predictive Marker for Early Switch in Treatment for Patients With Metastatic (Stage IV) Breast Cancer
University of Miami
NCT05826964
Her2-BATS and Pembrolizumab in Metastatic Breast Cancer
University of Virginia
NCT03272334
[18F]FLT PET/CT in Rb+ Metastatic Breast Cancer
University of Pennsylvania
NCT02608216
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 47 |
| Phase 2 | 52 |
| Phase 3 | 10 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Metastatic Breast Cancer Trial Landscape
140 indexed Metastatic Breast Cancer studies · 74 recruiting (53%).
Phase mix: 11 late (III/IV) vs 99 early (I/II).
Top sponsor: Memorial Sloan Kettering Cancer Center (12 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Metastatic Breast Cancer?
PlainTrial tracks 140 US clinical trials for Metastatic Breast Cancer, of which 74 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Metastatic Breast Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.