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COMPLETED Phase 2

Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer

NCT00894504 · View on ClinicalTrials.gov ↗

Study Summary

In this Phase II trial, the investigators will evaluate the combination of gemcitabine, carboplatin, and panitumumab in the treatment of patients with metastatic triple-negative breast cancer. In addition, to assess the efficacy of this combination, tumor tissue will be examined for the presence of various markers, including K-ras and PI3K-activating mutations, EGFR, PTEN, and p53. Correlation of tumor response with marker expression may define a patient subset that is particularly responsive to treatment with a panitumumab-containing combination.

Conditions Studied

Interventions

  • DRUG Carboplatin
  • DRUG Gemcitabine
  • DRUG Panitumumab

Study Locations (17)

Tennessee

  • Chattanooga Oncology Hematology Associates — Chattanooga
  • Family Cancer Center — Collierville
  • Tennessee Oncology — Nashville

Florida

  • Aventura Hospital and Medical Center — Aventura
  • Florida Cancer Specialists — Fort Myers

Maryland

  • Center for Cancer and Blood Disorders — Bethesda
  • National Capital Clinical Research Consortium — Bethesda

Missouri

  • St. Louis Cancer Care — Chesterfield
  • Research Medical Center — Kansas City

California

  • Los Robles — Thousand Oaks

Indiana

  • Providence Medical Group — Terre Haute

Kentucky

  • Norton Cancer Institute — Louisville

Nebraska

  • Nebraska Methodist Cancer Center — Omaha

Trial Details

FieldValue
Enrollment Target 71 participants
Start Date 2010-02
Est. Completion 2014-09
Phase Phase 2

Sponsor

SCRI Development Innovations

63 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00894504

The ClinicalTrials.gov registry entry for NCT00894504 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 71 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is SCRI Development Innovations, which has 63 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Metastatic Breast Cancer appearing as the primary indexed condition, and to 3 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00894504 reports 17 study locations spanning 12 distinct geographic areas — top geographies include Tennessee, Florida, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00894504 about?

NCT00894504 is a clinical study titled "Panitumumab, Gemcitabine and Carboplatin in Triple-Negative Metastatic Breast Cancer". In this Phase II trial, the investigators will evaluate the combination of gemcitabine, carboplatin, and panitumumab in the treatment of patients with metastatic triple-negative breast cancer. In addition, to assess the efficacy of this combination, tumor tissue will be examined for the presence of ...

What is the current status of trial NCT00894504?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 71 participants. The study started on 2010-02. Estimated completion is 2014-09.

What conditions does trial NCT00894504 study?

This clinical trial studies the following conditions: Metastatic Breast Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00894504?

The interventions under investigation include: Carboplatin (DRUG), Gemcitabine (DRUG), Panitumumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00894504?

This trial is sponsored by SCRI Development Innovations, which has 63 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00894504 being conducted?

This trial has 17 study locations across California, Florida, Indiana, Kentucky, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial