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RECRUITING Phase 1

HER-2 B Cell Peptide Vaccine

NCT06414733 · View on ClinicalTrials.gov ↗

Study Summary

This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an effective immune response to kill tumor cells.

Interventions

  • BIOLOGICAL Combination of MVF-HER-2 (597-626) and MVF-HER-2 (266-296) emulsified with ISA 720

Study Locations (1)

Indiana

  • Indiana University Melvin & Bren Simon Comprehensive Cancer Center — Indianpolis

Trial Details

FieldValue
Enrollment Target 42 participants
Start Date 2025-01-17
Est. Completion 2030-12-31
Phase Phase 1

Sponsor

Pravin T.P Kaumaya

2 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06414733

The ClinicalTrials.gov registry entry for NCT06414733 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pravin T.P Kaumaya, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Metastatic Breast Cancer appearing as the primary indexed condition, and to 1 intervention — of which Combination of MVF-HER-2 (597-626) and MVF-HER-2 (266-296) emulsified with ISA 720 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06414733 reports 1 study location spanning 1 distinct geographic area — top geographies include Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06414733 about?

NCT06414733 is a clinical study titled "HER-2 B Cell Peptide Vaccine". This phase I trial studies the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumors. Vaccines made from antibodies and peptides combined with tumor cells may help the body build an effective immune response to kill tumor cells.

What is the current status of trial NCT06414733?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 42 participants. The study started on 2025-01-17. Estimated completion is 2030-12-31.

What conditions does trial NCT06414733 study?

This clinical trial studies the following conditions: Metastatic Breast Cancer, HER2-positive Breast Cancer, HER2-positive Gastric Cancer, Metastatic Gastrointestinal Carcinoma, EGFR Overexpression. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06414733?

The interventions under investigation include: Combination of MVF-HER-2 (597-626) and MVF-HER-2 (266-296) emulsified with ISA 720 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06414733?

This trial is sponsored by Pravin T.P Kaumaya, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06414733 being conducted?

This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial