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NCT04990921 · ClinicalTrials.gov registry record · Phase 2
Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer
A Phase 2 study of Metastatic Breast Cancer, sponsored by University of Louisville.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT04990921: Recruiting Phase 2 study of Metastatic Breast Cancer, sponsored by University of Louisville.
NCT04990921 is a Phase 2 study of Metastatic Breast Cancer that is actively recruiting participants, run by University of Louisville. The registered enrollment target is 15 participants, below the 205-participant average among 139 other Metastatic Breast Cancer trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04990921, a Phase 2 study of Metastatic Breast Cancer, is actively recruiting participants, sponsored by University of Louisville.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a phase 2, open-label, single-arm trial designed to evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in combination with pembrolizumab following disease progression after two prior lines of standard therapy in unresectable metastatic stage IV breast cancer
Primary Outcome
Overall Response Rate (complete response \[CR\]+partial response \[PR\] by investigator assessment using modified RECIST v1.1) at week 24
Conditions Studied
Interventions
- COMBINATION_PRODUCT Palliative Radiation and Pembrolizumab
Study Locations (1)
Kentucky
- James Graham Brown Cancer Center - Louisville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2021-09-02 |
| Est. Completion | 2031-07-01 |
| Phase | Phase 2 |
What NCT04990921 shows while recruiting
NCT04990921 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 205-participant average among 139 other Metastatic Breast Cancer trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Metastatic Breast Cancer appearing as the primary indexed condition, and to 1 intervention - of which Palliative Radiation and Pembrolizumab is the first listed.
NCT04990921 reports a single indexed study location in Kentucky.
Frequently Asked Questions
What is clinical trial NCT04990921 about?
NCT04990921 is a clinical study titled "Study of Palliative Radiation Combined with Pembrolizumab in Unresectable Metastatic Stage IV Breast Cancer". This is a phase 2, open-label, single-arm trial designed to evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) in combination with pembrolizumab following disease progression after two prior lines of standard therapy in unresectable metastatic stage IV breast cancer
What is the current status of trial NCT04990921?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 15 participants. The study started on 2021-09-02. Estimated completion is 2031-07-01.
What conditions does trial NCT04990921 study?
This clinical trial studies the following conditions: Metastatic Breast Cancer.
What interventions are being tested in trial NCT04990921?
The interventions under investigation include: Palliative Radiation and Pembrolizumab (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT04990921?
This trial is sponsored by University of Louisville, which has 217 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04990921 being conducted?
This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metastatic Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04990921's enrollment target sits among peer trials
15 128th of 139 higher than 8 of 139 other Metastatic Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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