Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)

NCT06979596 · View on ClinicalTrials.gov ↗

Study Summary

Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones. Researchers will compare MK-5684 to the standard treatments for each cancer type in this study. The goal of this study is to learn if people who receive MK-5684 live longer without the cancer growing or spreading compared to people who receive a standard treatment.

Conditions Studied

Interventions

  • DRUG Fulvestrant
  • DRUG Rescue Medications
  • DRUG Opevesostat
  • DRUG Fludrocortisone/ Fludrocortisone acetate
  • DRUG Dexamethasone/Dexamethasone acetate

Study Locations (20)

Texas

  • Baylor College of Medicine Medical Center ( Site 0004) — Houston
  • Mays Cancer Center ( Site 0039) — San Antonio

Buenos Aires F.D.

  • Centro Medico Dr. Doreski - Fundación Respirar ( Site 0302) — Buenos Aires
  • Instituto Alexander Fleming ( Site 0303) — Buenos Aires

Region M. de Santiago

  • FALP ( Site 3300) — Santiago
  • Pontificia Universidad Catolica de Chile ( Site 3307) — Santiago

Alaska

  • Alaska Womens Cancer Care ( Site 0037) — Anchorage

Florida

  • Mount Sinai Cancer Center ( Site 0009) — Miami Beach

Louisiana

  • TRIALS 365 ( Site 0022) — Shreveport

Nebraska

  • Mary Lanning Healthcare ( Site 0019) — Hastings

New Jersey

  • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0021) — Hackensack

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2025-08-11
Est. Completion 2027-11-04
Phase Phase 2

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06979596

The ClinicalTrials.gov registry entry for NCT06979596 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Malignant Neoplasm appearing as the primary indexed condition, and to 5 interventions — of which Fulvestrant is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06979596 reports 20 study locations spanning 17 distinct geographic areas — top geographies include Texas, Buenos Aires F.D., Region M. de Santiago. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06979596 about?

NCT06979596 is a clinical study titled "A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)". Researchers want to learn if MK-5684 (the study medicine) can treat breast cancer, ovarian cancer, and endometrial cancer. MK-5684, the study medicine, is designed to treat cancer by blocking the body from making steroid hormones. Researchers will compare MK-5684 to the standard treatments for each...

What is the current status of trial NCT06979596?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 250 participants. The study started on 2025-08-11. Estimated completion is 2027-11-04.

What conditions does trial NCT06979596 study?

This clinical trial studies the following conditions: Malignant Neoplasm. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06979596?

The interventions under investigation include: Fulvestrant (DRUG), Rescue Medications (DRUG), Opevesostat (DRUG), Fludrocortisone/ Fludrocortisone acetate (DRUG), Dexamethasone/Dexamethasone acetate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06979596?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06979596 being conducted?

This trial has 20 study locations across Alaska, Florida, Louisiana, Nebraska, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial