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RECRUITING Phase 1

A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)

NCT07247110 · View on ClinicalTrials.gov ↗

Study Summary

Researchers are looking for new ways to treat certain advanced or metastatic solid tumors. The goal of this study is to learn about the safety of MK-4716 and if people tolerate it when taken alone or with other treatments.

Conditions Studied

Interventions

  • BIOLOGICAL Pembrolizumab
  • BIOLOGICAL Cetuximab
  • DRUG MK-4716

Study Locations (9)

Other

  • Rambam Health Care Campus ( Site 0252) — Haifa
  • Rabin Medical Center ( Site 0253) — Petah Tikva
  • Sheba Medical Center ( Site 0251) — Ramat Gan
  • Hospital General Universitari Vall d Hebron ( Site 0360) — Barcelona
  • Hospital Clinic de Barcelona ( Site 0362) — Barcelona
  • Hospital Universitario Fundacion Jimenez Diaz ( Site 0361) — Madrid

Texas

  • NEXT Oncology ( Site 0051) — Irving

Virginia

  • NEXT Virginia ( Site 0054) — Fairfax

Western Australia

  • One Clinical Research ( Site 0454) — Nedlands

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2025-12-16
Est. Completion 2030-12-01
Phase Phase 1

Sponsor

Merck Sharp & Dohme

741 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07247110

The ClinicalTrials.gov registry entry for NCT07247110 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Malignant Neoplasm appearing as the primary indexed condition, and to 3 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07247110 reports 9 study locations spanning 4 distinct geographic areas — top geographies include Other, Texas, Virginia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07247110 about?

NCT07247110 is a clinical study titled "A Clinical Study of MK-4716 in People With Certain Solid Tumors (MK-4716-001)". Researchers are looking for new ways to treat certain advanced or metastatic solid tumors. The goal of this study is to learn about the safety of MK-4716 and if people tolerate it when taken alone or with other treatments.

What is the current status of trial NCT07247110?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 250 participants. The study started on 2025-12-16. Estimated completion is 2030-12-01.

What conditions does trial NCT07247110 study?

This clinical trial studies the following conditions: Malignant Neoplasm. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07247110?

The interventions under investigation include: Pembrolizumab (BIOLOGICAL), Cetuximab (BIOLOGICAL), MK-4716 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07247110?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07247110 being conducted?

This trial has 9 study locations across Texas, Virginia, Western Australia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial