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ClinicalTrials.gov 88 recruiting now early-phase tilt #21 of 28,707 conditions

Lymphoma: early-phase trial registry

88 of 330 indexed Lymphoma trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #21 of 28,707 conditions by registered trial count.

330 US clinical trials · 88 currently recruiting · #21 of 28,707 conditions by registered trial count

Lymphoma: 330 US clinical trials tracked, 88 recruiting.

Lymphoma is the subject of 330 registered US clinical trials on ClinicalTrials.gov, 88 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 229 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 34 of these trials.

Enrollment posture brief

Registry condition lymphoma

OPEN 88 | RECR 27% | LATE 25 | EARLY 229 | RANK #21 | SPON 34

Nearest open-share peer: Age-related Macular Degeneration (27% recruiting · 75 trials)

Ovarian Cancer43.5%Type 2 Diabetes36.6%Lymphoma (this)27%Diabetes25.1%Schizophrenia23.9%
Open-enrollment share among volume-matched conditions near Lymphoma

Lymphoma lists 88 open slots (27% of 330 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Lymphoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Lymphoma is recruiting below its size-band peers.

    88 of 330 indexed trials (26.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Lymphoma trials is spread across many organizations.

    Memorial Sloan Kettering Cancer Center accounts for 34 of 330 trials (10.3%). 116 distinct sponsors appear on at least one study for this condition label.

  3. Most Lymphoma trials plan to enrol fewer than 100 people.

    Median target enrolment is 50 among the 300 trials that report a genuine target (sentinel values excluded). 213 of those (71%) plan for fewer than 100 participants.

  4. Lymphoma research is mostly interventional.

    299 interventional and 31 observational studies make up this index (90.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 1119Phase 2110Phase 322Phase 43

Open and recent trials

330 total, page 3 of 7

ACTIVE NOT RECRUITING Phase 2 120 participants

Combination of Lenalidomide and Rituximab in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL-SLL)

M.D. Anderson Cancer Center

NCT01446133

ACTIVE NOT RECRUITING Phase 1 114 participants

Trial of Duvelisib in Combination With Either Romidepsin or Bortezomib in Relapsed/Refractory T-cell Lymphomas

Memorial Sloan Kettering Cancer Center

NCT02783625

ACTIVE NOT RECRUITING Phase 2 113 participants

Combination Chemotherapy With or Without Autologous Stem Cell Transplant in Treating Patients With Central Nervous System B-Cell Lymphoma

Alliance for Clinical Trials in Oncology

NCT01511562

ACTIVE NOT RECRUITING NA 111 participants

Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma

M.D. Anderson Cancer Center

NCT05464823

ACTIVE NOT RECRUITING Phase 2 79 participants

SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)

M.D. Anderson Cancer Center

NCT01352520

ACTIVE NOT RECRUITING Phase 1 78 participants

A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia

Seattle Children's Hospital

NCT03330691

ACTIVE NOT RECRUITING NA 71 participants

Mind-Body Medicine for the Improvement of Quality of Life in Adolescents and Young Adults Coping With Lymphoma

M.D. Anderson Cancer Center

NCT04270266

ACTIVE NOT RECRUITING Phase 1 67 participants

A Phase I Study: PET Imaging of Cancer Patients Using [18F] 4-L-Fluoroglutamine (2S,4R)

Memorial Sloan Kettering Cancer Center

NCT01697930

ACTIVE NOT RECRUITING Phase 1 64 participants

Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma

National Cancer Institute (NCI)

NCT03502733

ACTIVE NOT RECRUITING Phase 2 63 participants

SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer

GeoVax

NCT04977024

ACTIVE NOT RECRUITING Phase 1 54 participants

Kappa-CD28 T Lymphocytes, Chronic Lymphocytic Leukemia, B-cell Lymphoma or Multiple Myeloma, CHARKALL

Baylor College of Medicine

NCT00881920

ACTIVE NOT RECRUITING Phase 2 51 participants

Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphoma

University of Chicago

NCT03995147

ACTIVE NOT RECRUITING NA 50 participants

Mindfulness Interventions to Improve Health Activation, Coping, and Stress Among Childhood Cancer Survivors

St. Jude Children's Research Hospital

NCT06053268

ACTIVE NOT RECRUITING NA 50 participants

Chaplain-Delivered Compassion Meditation to Improve Spiritual Care of Patients Receiving Stem Cell Transplantation

Emory University

NCT06328699

ACTIVE NOT RECRUITING Phase 2 48 participants

Cognitive Behavioral Therapy in Helping Patients With Acute Myeloid Leukemia or Lymphoma With Cancer-Related Fatigue

M.D. Anderson Cancer Center

NCT03747757

ACTIVE NOT RECRUITING Phase 2 47 participants

Combination Therapy With Entinostat and Pembrolizumab in Relapsed and Refractory Lymphomas

Memorial Sloan Kettering Cancer Center

NCT03179930

ACTIVE NOT RECRUITING Phase 2 46 participants

A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma

Hoffmann-La Roche

NCT04980222

ACTIVE NOT RECRUITING NA 45 participants

An Intervention to Help Patients and Caregivers Manage Stress and Improve Communication Skills When Talking About Cancer

Memorial Sloan Kettering Cancer Center

NCT03794635

ACTIVE NOT RECRUITING Phase 1 43 participants

Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL

UNC Lineberger Comprehensive Cancer Center

NCT03602157

ACTIVE NOT RECRUITING Phase 1 42 participants

A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD22 for Relapsed/Refractory Leukemia or Lymphoma

Seattle Children's Hospital

NCT04571138

ACTIVE NOT RECRUITING Phase 1 39 participants

A Study of Melphalan in People With Lymphoma Getting an Autologous Hematopoietic Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT05540340

ACTIVE NOT RECRUITING Phase 1 38 participants

Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL

UNC Lineberger Comprehensive Cancer Center

NCT02690545

ACTIVE NOT RECRUITING Early Phase 1 37 participants

Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel

Masonic Cancer Center, University of Minnesota

NCT04514029

ACTIVE NOT RECRUITING Phase 1 36 participants

Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant

Bellicum Pharmaceuticals

NCT01744223

ACTIVE NOT RECRUITING Phase 4 30 participants

Immunogenicity and Clinical Efficacy of 20-valent Pneumococcal Conjugate Vaccine (PCV20) in Lymphoma Survivors After Treatment With Anti-CD20 Therapy

M.D. Anderson Cancer Center

NCT06049134

ACTIVE NOT RECRUITING NA 30 participants

Radiation Dose Study for Relapsed/Refractory Hodgkin/Non-Hodgkin Lymphoma

University of Chicago

NCT05019976

ACTIVE NOT RECRUITING Phase 1 28 participants

A Phase I Study of Bendamustine and Melphalan Conditioning and Autologous Stem Cell Transplantation for Treatment of Multiple Myeloma and Relapsed/Refractory B-cell Lymphoma in Elderly Patients

Memorial Sloan Kettering Cancer Center

NCT03352765

ACTIVE NOT RECRUITING Phase 1 25 participants

Carmustine, Etoposide, Cyclophosphamide, and Stem Cell Transplant in Treating Patients With HIV-Associated Lymphoma

City of Hope Medical Center

NCT00641381

ACTIVE NOT RECRUITING Phase 2 24 participants

A Study of CPI-613 for Patients With Relapsed or Refractory Burkitt Lymphoma/Leukemia or High-Grade B-Cell Lymphoma With High-Risk Translocations

Memorial Sloan Kettering Cancer Center

NCT03793140

ACTIVE NOT RECRUITING Early Phase 1 22 participants

A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT05495464

ACTIVE NOT RECRUITING Phase 3 21 participants

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Dartmouth-Hitchcock Medical Center

NCT03480360

ACTIVE NOT RECRUITING NA 20 participants

Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05763563

ACTIVE NOT RECRUITING Phase 1 19 participants

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

UNC Lineberger Comprehensive Cancer Center

NCT03696784

ACTIVE NOT RECRUITING Phase 1 19 participants

In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the CD19 Antigen in B-cell Malignancies

Memorial Sloan Kettering Cancer Center

NCT01430390

ACTIVE NOT RECRUITING Phase 1 18 participants

Administration of T Lymphocytes for Prevention of Relapse of Lymphomas

UNC Lineberger Comprehensive Cancer Center

NCT02663297

ACTIVE NOT RECRUITING Phase 1 18 participants

Axi-cel in CNS Lymphoma

Dana-Farber Cancer Institute

NCT04608487

ACTIVE NOT RECRUITING Phase 1 16 participants

CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma

Seattle Children's Hospital

NCT03684889

ACTIVE NOT RECRUITING Phase 2 16 participants

BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma

UNC Lineberger Comprehensive Cancer Center

NCT03264131

ACTIVE NOT RECRUITING Phase 1 14 participants

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

Memorial Sloan Kettering Cancer Center

NCT02932280

ACTIVE NOT RECRUITING Phase 1 10 participants

CD22-CAR T Cells in Children and Young Adults With B Cell Malignancies

Stanford University

NCT04088864

ACTIVE NOT RECRUITING Phase 1 10 participants

Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant

Bellicum Pharmaceuticals

NCT02477878

ACTIVE NOT RECRUITING Phase 1 9 participants

A Study of N-Acetylcysteine (N-AC) in People Receiving CAR T-cell Therapy for Lymphoma

Memorial Sloan Kettering Cancer Center

NCT05081479

ACTIVE NOT RECRUITING Phase 1 8 participants

Autologous/Allogeneic TGFbeta-resistant LMP-specific CTL, Lymphoma (TGF-beta)

Baylor College of Medicine

NCT00368082

COMPLETED NA 1,053 participants

Effectiveness of Lay Navigators in Meeting Cancer Patients' Non-Clinical Needs: A Pilot Study

Stanford University

NCT03245788

COMPLETED 939 participants

SWOG-8947 Collecting and Storing Blood Samples From Patients With Previously Untreated Non-Hodgkin Lymphoma

SWOG Cancer Research Network

NCT01000558

COMPLETED Phase 3 838 participants

A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma

Janssen Research & Development

NCT01855750

COMPLETED Phase 3 630 participants

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma

Eastern Cooperative Oncology Group

NCT00003150

COMPLETED Phase 3 571 participants

S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma

SWOG Cancer Research Network

NCT00006721

COMPLETED Phase 3 502 participants

Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer

Mayo Clinic

NCT00661999

COMPLETED Phase 3 472 participants

Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer

Radiation Therapy Oncology Group

NCT00053053

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Phase Distribution

PhaseTrial count
Phase 1 119
Phase 2 110
Phase 3 22
Phase 4 3

Named interventions

Most-linked intervention names on Lymphoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

cyclophosphamide Drug
30 trials
rituximab Biological
26 trials
Cyclophosphamide Drug
23 trials
Rituximab Drug
21 trials
filgrastim Biological
17 trials
cytarabine Drug
14 trials
etoposide Drug
13 trials
Fludarabine Drug
13 trials

US sites by state

Facility locations filed on Lymphoma trials. A trial with sites in several states counts in each.

California 91 trials
New York 82 trials
Texas 71 trials
Maryland 50 trials
Illinois 50 trials
Massachusetts 47 trials
Florida 45 trials
North Carolina 37 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Lymphoma page

330 registered trials, 88 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Lymphoma condition card totals 330 registered trials; most-linked intervention cyclophosphamide; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.