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ClinicalTrials.gov 88 recruiting now official registry

Lymphoma clinical trials

88 of 330 indexed Lymphoma trials are currently recruiting.

330 US clinical trials · 88 currently recruiting

Lymphoma is the subject of 330 registered US clinical trials on ClinicalTrials.gov, 88 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 229 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 34 of these trials.

The research picture

Lymphoma has 330 registered US clinical trials, 88 of them open to new participants right now, about 27% of the total.

88
recruiting participants now
27%
of trials open to enrollment
25
in Phase 3–4 (later-stage)
34
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 1119Phase 2110Phase 322Phase 43

Active & Recent Trials

330 total, page 3 of 7

ACTIVE NOT RECRUITING Phase 2 120 participants

Combination of Lenalidomide and Rituximab in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL-SLL)

M.D. Anderson Cancer Center

NCT01446133

ACTIVE NOT RECRUITING Phase 1 114 participants

Trial of Duvelisib in Combination With Either Romidepsin or Bortezomib in Relapsed/Refractory T-cell Lymphomas

Memorial Sloan Kettering Cancer Center

NCT02783625

ACTIVE NOT RECRUITING Phase 2 113 participants

Combination Chemotherapy With or Without Autologous Stem Cell Transplant in Treating Patients With Central Nervous System B-Cell Lymphoma

Alliance for Clinical Trials in Oncology

NCT01511562

ACTIVE NOT RECRUITING NA 111 participants

Feasibility of Combined Genomics/Transcriptomics for Patients With Lymphoma

M.D. Anderson Cancer Center

NCT05464823

ACTIVE NOT RECRUITING Phase 2 79 participants

SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)

M.D. Anderson Cancer Center

NCT01352520

ACTIVE NOT RECRUITING Phase 1 78 participants

A Feasibility and Safety Study of Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy for CD19+CD22+ Leukemia

Seattle Children's Hospital

NCT03330691

ACTIVE NOT RECRUITING NA 71 participants

Mind-Body Medicine for the Improvement of Quality of Life in Adolescents and Young Adults Coping With Lymphoma

M.D. Anderson Cancer Center

NCT04270266

ACTIVE NOT RECRUITING Phase 1 67 participants

A Phase I Study: PET Imaging of Cancer Patients Using [18F] 4-L-Fluoroglutamine (2S,4R)

Memorial Sloan Kettering Cancer Center

NCT01697930

ACTIVE NOT RECRUITING Phase 1 64 participants

Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma

National Cancer Institute (NCI)

NCT03502733

ACTIVE NOT RECRUITING Phase 2 63 participants

SARS-CoV-2 Vaccine (GEO-CM04S1) Versus mRNA SARS-COV-2 Vaccine in Patients With Blood Cancer

GeoVax

NCT04977024

ACTIVE NOT RECRUITING Phase 1 54 participants

Kappa-CD28 T Lymphocytes, Chronic Lymphocytic Leukemia, B-cell Lymphoma or Multiple Myeloma, CHARKALL

Baylor College of Medicine

NCT00881920

ACTIVE NOT RECRUITING Phase 2 51 participants

Pembrolizumab in Combination With Chemotherapy for Patients With Untreated B Cell Lymphoma

University of Chicago

NCT03995147

ACTIVE NOT RECRUITING NA 50 participants

Mindfulness Interventions to Improve Health Activation, Coping, and Stress Among Childhood Cancer Survivors

St. Jude Children's Research Hospital

NCT06053268

ACTIVE NOT RECRUITING NA 50 participants

Chaplain-Delivered Compassion Meditation to Improve Spiritual Care of Patients Receiving Stem Cell Transplantation

Emory University

NCT06328699

ACTIVE NOT RECRUITING Phase 2 48 participants

Cognitive Behavioral Therapy in Helping Patients With Acute Myeloid Leukemia or Lymphoma With Cancer-Related Fatigue

M.D. Anderson Cancer Center

NCT03747757

ACTIVE NOT RECRUITING Phase 2 47 participants

Combination Therapy With Entinostat and Pembrolizumab in Relapsed and Refractory Lymphomas

Memorial Sloan Kettering Cancer Center

NCT03179930

ACTIVE NOT RECRUITING Phase 2 46 participants

A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma

Hoffmann-La Roche

NCT04980222

ACTIVE NOT RECRUITING NA 45 participants

An Intervention to Help Patients and Caregivers Manage Stress and Improve Communication Skills When Talking About Cancer

Memorial Sloan Kettering Cancer Center

NCT03794635

ACTIVE NOT RECRUITING Phase 1 43 participants

Study of CAR-T Cells Expressing CD30 and CCR4 for r/r CD30+ HL and CTCL

UNC Lineberger Comprehensive Cancer Center

NCT03602157

ACTIVE NOT RECRUITING Phase 1 42 participants

A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD22 for Relapsed/Refractory Leukemia or Lymphoma

Seattle Children's Hospital

NCT04571138

ACTIVE NOT RECRUITING Phase 1 39 participants

A Study of Melphalan in People With Lymphoma Getting an Autologous Hematopoietic Cell Transplant

Memorial Sloan Kettering Cancer Center

NCT05540340

ACTIVE NOT RECRUITING Phase 1 38 participants

Study of CD30 CAR for Relapsed/Refractory CD30+ HL and CD30+ NHL

UNC Lineberger Comprehensive Cancer Center

NCT02690545

ACTIVE NOT RECRUITING Early Phase 1 37 participants

Neurotoxicity Prophylaxis With Intrathecal Dexamethasone and Simvastatin Post Axi-Cel

Masonic Cancer Center, University of Minnesota

NCT04514029

ACTIVE NOT RECRUITING Phase 1 36 participants

Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant

Bellicum Pharmaceuticals

NCT01744223

ACTIVE NOT RECRUITING Phase 4 30 participants

Immunogenicity and Clinical Efficacy of 20-valent Pneumococcal Conjugate Vaccine (PCV20) in Lymphoma Survivors After Treatment With Anti-CD20 Therapy

M.D. Anderson Cancer Center

NCT06049134

ACTIVE NOT RECRUITING NA 30 participants

Radiation Dose Study for Relapsed/Refractory Hodgkin/Non-Hodgkin Lymphoma

University of Chicago

NCT05019976

ACTIVE NOT RECRUITING Phase 1 28 participants

A Phase I Study of Bendamustine and Melphalan Conditioning and Autologous Stem Cell Transplantation for Treatment of Multiple Myeloma and Relapsed/Refractory B-cell Lymphoma in Elderly Patients

Memorial Sloan Kettering Cancer Center

NCT03352765

ACTIVE NOT RECRUITING Phase 1 25 participants

Carmustine, Etoposide, Cyclophosphamide, and Stem Cell Transplant in Treating Patients With HIV-Associated Lymphoma

City of Hope Medical Center

NCT00641381

ACTIVE NOT RECRUITING Phase 2 24 participants

A Study of CPI-613 for Patients With Relapsed or Refractory Burkitt Lymphoma/Leukemia or High-Grade B-Cell Lymphoma With High-Risk Translocations

Memorial Sloan Kettering Cancer Center

NCT03793140

ACTIVE NOT RECRUITING Early Phase 1 22 participants

A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT05495464

ACTIVE NOT RECRUITING Phase 3 21 participants

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Dartmouth-Hitchcock Medical Center

NCT03480360

ACTIVE NOT RECRUITING NA 20 participants

Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

H. Lee Moffitt Cancer Center and Research Institute

NCT05763563

ACTIVE NOT RECRUITING Phase 1 19 participants

Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

UNC Lineberger Comprehensive Cancer Center

NCT03696784

ACTIVE NOT RECRUITING Phase 1 19 participants

In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the CD19 Antigen in B-cell Malignancies

Memorial Sloan Kettering Cancer Center

NCT01430390

ACTIVE NOT RECRUITING Phase 1 18 participants

Administration of T Lymphocytes for Prevention of Relapse of Lymphomas

UNC Lineberger Comprehensive Cancer Center

NCT02663297

ACTIVE NOT RECRUITING Phase 1 18 participants

Axi-cel in CNS Lymphoma

Dana-Farber Cancer Institute

NCT04608487

ACTIVE NOT RECRUITING Phase 1 16 participants

CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma

Seattle Children's Hospital

NCT03684889

ACTIVE NOT RECRUITING Phase 2 16 participants

BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma

UNC Lineberger Comprehensive Cancer Center

NCT03264131

ACTIVE NOT RECRUITING Phase 1 14 participants

Safety and Dose Finding Study of Neratinib in Children and Young Adults With Cancer That Has Returned or Not Responded to Treatment

Memorial Sloan Kettering Cancer Center

NCT02932280

ACTIVE NOT RECRUITING Phase 1 10 participants

CD22-CAR T Cells in Children and Young Adults With B Cell Malignancies

Stanford University

NCT04088864

ACTIVE NOT RECRUITING Phase 1 10 participants

Study of Gene Modified Donor T Cell Infusion in Patients With Recurrent Disease After Allogeneic Transplant

Bellicum Pharmaceuticals

NCT02477878

ACTIVE NOT RECRUITING Phase 1 9 participants

A Study of N-Acetylcysteine (N-AC) in People Receiving CAR T-cell Therapy for Lymphoma

Memorial Sloan Kettering Cancer Center

NCT05081479

ACTIVE NOT RECRUITING Phase 1 8 participants

Autologous/Allogeneic TGFbeta-resistant LMP-specific CTL, Lymphoma (TGF-beta)

Baylor College of Medicine

NCT00368082

COMPLETED NA 1,053 participants

Effectiveness of Lay Navigators in Meeting Cancer Patients' Non-Clinical Needs: A Pilot Study

Stanford University

NCT03245788

COMPLETED 939 participants

SWOG-8947 Collecting and Storing Blood Samples From Patients With Previously Untreated Non-Hodgkin Lymphoma

SWOG Cancer Research Network

NCT01000558

COMPLETED Phase 3 838 participants

A Study of the Bruton's Tyrosine Kinase Inhibitor, PCI-32765 (Ibrutinib), in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Non-Germinal Center B-Cell Subtype of Diffuse Large B-Cell Lymphoma

Janssen Research & Development

NCT01855750

COMPLETED Phase 3 630 participants

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma

Eastern Cooperative Oncology Group

NCT00003150

COMPLETED Phase 3 571 participants

S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma

SWOG Cancer Research Network

NCT00006721

COMPLETED Phase 3 502 participants

Darbepoetin Alfa With or Without Iron in Treating Anemia Caused By Chemotherapy in Patients With Cancer

Mayo Clinic

NCT00661999

COMPLETED Phase 3 472 participants

Comparison of Nutritional Supplements in Preventing Weight Loss in Patients With Cancer

Radiation Therapy Oncology Group

NCT00053053

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Phase Distribution

PhaseTrial count
Phase 1 119
Phase 2 110
Phase 3 22
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Lymphoma Trial Landscape

330 indexed Lymphoma studies · 88 recruiting (27%).

Phase mix: 25 late (III/IV) vs 229 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (34 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Lymphoma?

PlainTrial tracks 330 US clinical trials for Lymphoma, of which 88 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.