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COMPLETED Phase 3

Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma

NCT00003150 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known if combination chemotherapy is more effective with or without rituximab for non-Hodgkin's lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy with or without rituximab in treating older patients who have non-Hodgkin's lymphoma.

Conditions Studied

Interventions

  • DRUG prednisone
  • DRUG cyclophosphamide
  • BIOLOGICAL rituximab
  • DRUG doxorubicin hydrochloride
  • DRUG CHOP regimen

Study Locations (20)

California

  • Cancer Center and Beckman Research Institute, City of Hope — Duarte
  • Veterans Affairs Medical Center - Long Beach — Long Beach
  • USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles
  • Veterans Affairs Medical Center - West Los Angeles — Los Angeles
  • Jonsson Comprehensive Cancer Center, UCLA — Los Angeles
  • Veterans Affairs Outpatient Clinic - Martinez — Martinez
  • CCOP - Bay Area Tumor Institute — Oakland
  • Chao Family Comprehensive Cancer Center — Orange
  • University of California Davis Medical Center — Sacramento
  • CCOP - Santa Rosa Memorial Hospital — Santa Rosa
  • David Grant Medical Center — Travis Air Force Base

Arizona

  • CCOP - Greater Phoenix — Phoenix
  • Veterans Affairs Medical Center - Phoenix (Hayden) — Phoenix
  • Veterans Affairs Medical Center - Tucson — Tucson
  • Arizona Cancer Center — Tucson

Arkansas

  • University of Arkansas for Medical Sciences — Little Rock
  • Veterans Affairs Medical Center - Little Rock (McClellan) — Little Rock

Colorado

  • University of Colorado Cancer Center — Denver
  • Veterans Affairs Medical Center - Denver — Denver

Alabama

  • MBCCOP - Gulf Coast — Mobile

Trial Details

FieldValue
Enrollment Target 630 participants
Start Date 1997-12
Est. Completion 2006-09
Phase Phase 3

Sponsor

Eastern Cooperative Oncology Group

30 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00003150

The ClinicalTrials.gov registry entry for NCT00003150 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 630 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eastern Cooperative Oncology Group, which has 30 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which prednisone is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00003150 reports 20 study locations spanning 5 distinct geographic areas — top geographies include California, Arizona, Arkansas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00003150 about?

NCT00003150 is a clinical study titled "Combination Chemotherapy With or Without Monoclonal Antibody Therapy in Treating Older Patients With Non-Hodgkin's Lymphoma". RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells. It is not yet known i...

What is the current status of trial NCT00003150?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 630 participants. The study started on 1997-12. Estimated completion is 2006-09.

What conditions does trial NCT00003150 study?

This clinical trial studies the following conditions: Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00003150?

The interventions under investigation include: prednisone (DRUG), cyclophosphamide (DRUG), rituximab (BIOLOGICAL), doxorubicin hydrochloride (DRUG), CHOP regimen (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00003150?

This trial is sponsored by Eastern Cooperative Oncology Group, which has 30 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00003150 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial