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NCT00776412 · ClinicalTrials.gov registry record
Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults
A clinical trial of Inflammation and Pathologic Processes, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Completed
- Registry status
- 310
- Enrollment target
- 1
- Study location
NCT00776412: Completed study of Inflammation and Pathologic Processes, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
NCT00776412 is a study of Inflammation and Pathologic Processes that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 310 participants, roughly in line with the 286-participant average among 132 other Inflammation trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00776412, a study of Inflammation and Pathologic Processes, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- COMPLETED
- Registry status
- 310 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will collect information about markers of inflammation, blood clotting and blood vessel function in HIV-infected adults and healthy volunteers. Biomarkers are biological indicators that have been associated with disease. Certain markers of inflammation, blood clotting, and blood vessel function have been associated with risk of cardiovascular disease, stroke and death. One marker, called D-dimer, is a breakdown product of blood clots that has been associated with serious medical conditions, including deep vein thrombosis (formation of a blood clot in a vein deep in the body) and pulmonary embolism (blockage in the pulmonary artery that occurs when a blood clot from a vein breaks away, travels to the pulmonary artery and lodges there). High D-dimer levels have also been associated with cardiovascular disease and stroke risk. In a recent study of HIV-infected patients, higher D-dimer levels were strongly correlated with risk of death from any cause. The significance of changes in D-dimer and other biomarkers in HIV-infected adults is not well understood. This study will further explore D-dimer and other biomarkers to try to better understand the relationships between them and HIV infection. Healthy volunteers and HIV-infected adults 18 years of age or older may be eligible for this study. Two visits are involved, as follows: Visit 1 (screening visit to determine eligibility) * Medical history and physical examination. * Blood tests for HIV infection, blood counts, liver and kidney function. * Pregnancy test for women who can become pregnant. Visit 2 * Blood tests for hepatitis B and C * Blood tests for markers of inflammation and blood clotting. * Blood test for genetic changes that influence blood clotting. In some cases, visits 1 and 2 may be combined. Optional additional visits (up to 8 visits over 3 years) * Additional blood draws for investigation of specific clinical or laboratory findings may be requested.
Primary Outcome
The findings of this exploratory study will be used to generate hypotheses for future research studies.
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 310 participants |
| Start Date | 2008-11-20 |
What the finished NCT00776412 record still lists
NCT00776412 is an observational study that tracks outcomes without assigning an intervention. The registered 310 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 286-participant average among 132 other Inflammation trials with a reported enrollment target.
The record links to 2 conditions, with Inflammation appearing as the primary indexed condition, and to 0 interventions.
NCT00776412 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00776412 about?
NCT00776412 is a clinical study titled "Blood Markers of Inflammation, Blood Clotting and Blood Vessel Function in HIV-infected Adults". This study will collect information about markers of inflammation, blood clotting and blood vessel function in HIV-infected adults and healthy volunteers. Biomarkers are biological indicators that have been associated with disease. Certain markers of inflammation, blood clotting, and blood vessel fu...
What is the current status of trial NCT00776412?
This trial is currently completed. The enrollment target is 310 participants. The study started on 2008-11-20.
What conditions does trial NCT00776412 study?
This clinical trial studies the following conditions: Inflammation, Pathologic Processes.
Who is sponsoring clinical trial NCT00776412?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00776412 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00776412's enrollment target sits among peer trials
310 17th of 132 higher than 116 of 132 other Inflammation trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Inflammation trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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