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NCT01143519 · ClinicalTrials.gov registry record
Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage
A clinical trial of Cancer and Inflammation, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- Completed
- Registry status
- 178
- Enrollment target
- 1
- Study location
NCT01143519: Completed study of Cancer and Inflammation, sponsored by National Institute of Environmental Health Sciences (NIEHS).
NCT01143519 is a study of Cancer and Inflammation that has completed, run by National Institute of Environmental Health Sciences (NIEHS). The registered enrollment target is 178 participants, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01143519, a study of Cancer and Inflammation, has completed, sponsored by National Institute of Environmental Health Sciences (NIEHS).
- COMPLETED
- Registry status
- 178 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: \- Research has shown that certain proteins in cells may be linked to higher risks of developing inflammations, tumors, and other medical problems. By examining how the blood cells of healthy volunteers respond to environmental exposures, researchers hope to better understand the relationship of genes, environmental factors, and human diseases. Objectives: \- To examine how specific genes and proteins in blood cells respond to environmental exposures. Eligibility: \- Healthy volunteers between 18 and 45 years of age. Design: * The study will involve one visit of 45 to 60 minutes. * Participants will be screened with a brief physical examination and finger stick to determine if they are eligible to donate blood for the study, and will complete a questionnaire about any medications or other drugs (e.g., cigarettes) they may be taking. * Participants will provide a blood sample for research purposes.
Primary Outcome
The primary endpoint of this study is p53 target gene expression measured by RTPCR for the following five SNPs: p53 rs1042522, MDM2 rs2279744, FLT1 C-677T, TLR8 rs3761624 and RMM1 rs1465952.
Conditions Studied
Study Locations (1)
North Carolina
- NIEHS Clinical Research Unit (CRU) - Research Triangle Park
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 178 participants |
| Start Date | 2012-05-21 |
What the finished NCT01143519 record still lists
NCT01143519 is an observational study that tracks outcomes without assigning an intervention. The registered 178 participants enrollment target is mid-sized for trials with a published cap, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (95% lower).
The record links to 4 conditions, with Cancer appearing as the primary indexed condition, and to 0 interventions.
NCT01143519 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT01143519 about?
NCT01143519 is a clinical study titled "Study of the Effect of SNPs in p53 and p53 Response Elements on the Inflammatory Response to DNA Damage". Background: \- Research has shown that certain proteins in cells may be linked to higher risks of developing inflammations, tumors, and other medical problems. By examining how the blood cells of healthy volunteers respond to environmental exposures, researchers hope to better understand the relati...
What is the current status of trial NCT01143519?
This trial is currently completed. The enrollment target is 178 participants. The study started on 2012-05-21.
What conditions does trial NCT01143519 study?
This clinical trial studies the following conditions: Cancer, Inflammation, Cardiomyopathy, HIV-1 Seropositive.
Who is sponsoring clinical trial NCT01143519?
This trial is sponsored by National Institute of Environmental Health Sciences (NIEHS), which has 145 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01143519 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01143519's enrollment target sits among peer trials
178 248th of 615 higher than 368 of 615 other Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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