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HIV clinical trials
109 of 304 indexed HIV trials are currently recruiting.
304 US clinical trials · 109 currently recruiting
HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.
The research picture
HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.
- 109
- recruiting participants now
- 36%
- of trials open to enrollment
- 25
- in Phase 3–4 (later-stage)
- 24
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
304 total, page 6 of 7
Cognitive Behavior Therapy (CBT)-Based Group Intervention to Reduce Inflammation in Older People With HIV
Massachusetts General Hospital
NCT05434741
Increasing Motivation for Antiretroviral Therapy Initiation: A Pilot Intervention
University of Maryland, Baltimore
NCT02055417
A Phase 1, Open Label, Dose-escalation Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 3BNC117
Rockefeller University
NCT02018510
Rifaximin for Chronic Immune Activation in People With HIV
National Cancer Institute (NCI)
NCT01866826
Lower Extremity Splinting to Manage Pain and Sleep Disturbances Associated With HIV/AIDS Related Peripheral Neuropathy
Texas Woman's University
NCT01419314
Exercise and Pioglitazone for HIV-Metabolic Syndromes
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00639457
A Clinical Trial to Evaluate Safety, Tolerability, and Immunogenicity of Adjuvanted HIV-1 Fusion Peptide Conjugate Vaccine Alone or in Prime-Boost Regimens With Adjuvanted HIV-1 Envelope Trimer 4571 and HIV-1 Trimer 6931 Vaccines in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT05470400
Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics
University of Colorado, Denver
NCT01386970
Development of an Empowerment Intervention for Young Women Living With HIV
University of North Carolina, Chapel Hill
NCT01454921
Treatment for Depression Among HIV-Infected Youth
University of North Carolina, Chapel Hill
NCT01049789
Neurocognitive Effects of Buprenorphine Among HIV+ and HIV-Opioid Users
Albert Einstein College of Medicine
NCT01108679
Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults
University Hospitals Cleveland Medical Center
NCT01046682
Technology-Enhanced Peer Navigation to Improve IDUs' Engagement in HIV Care
Johns Hopkins Bloomberg School of Public Health
NCT01941108
Safety, Tolerability, and Effect of TMC207 and Efavirenz in Healthy Volunteers
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00992069
Validation of a Urine Assay to Measure Tenofovir Levels in Patients Taking Tenofovir Alafenamide
Philadelphia Fight
NCT03350672
Contingency Management in HIV Care for Both Stimulant Use & ART Adherence
University of California, San Francisco
NCT06564792
Adapting the Finding Respect and Ending Stigma Around HIV (FRESH) Intervention for the Dominican Republic
Florida State University
NCT04491539
PET/CT Imaging Companion Study To ACTG A5314
Massachusetts General Hospital
NCT02312219
Safety, Pharmacokinetics and Acceptability of PC-1005 for Vaginal Use
Population Council
NCT02033109
Pilot Study of the Effects of Exercise on Aging Among Older Persons With HIV
University of California, San Francisco
NCT01860261
Strength Training and Endurance Exercise for LIFE
VA Office of Research and Development
NCT02101060
A Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 10-1074
Rockefeller University
NCT02511990
Improving Memory Performance by Applying Cognitive Training
Duke University
NCT02216591
NOLA GEM: Feasibility and Acceptability of an MHealth Intervention for Violence-affected PLWH
Tulane University
NCT05784714
SmartManage Stress Management for HIV+ Cancer Survivors
University of Miami
NCT04544917
Exploring HIV Entry Blockade as a Pre-exposure Prophylaxis Strategy in Women
Emory University
NCT01749566
CBSM Intervention Via mHealth to Ameliorate HIV-related Fatigue
Medical University of South Carolina
NCT03149094
CRUSH-PrEP for Women Project
University of California, San Francisco
NCT02852226
Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs
Rhonda Brand
NCT04302896
Use of 99mTc Tilmanocept for Imaging Arterial Inflammation
Massachusetts General Hospital
NCT02542371
Impact of a Short-Term Analytical Treatment Interruption and Re-Initiation of Antiretroviral Therapy on Immunologic and Virologic Parameters in HIV-Infected Individuals
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03225118
Developing a Trauma-focused Intervention for Older Adults Living With HIV
University of South Carolina
NCT05287230
Y2Prevent: Preventing Drug Use and HIV Through Empowerment, Social Support and Mentorship (Y2P)
Children's Hospital Los Angeles
NCT04504981
Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers
University of Colorado, Denver
NCT01427504
Effects of Biktarvy on CFR in Stable HIV Patients
Brigham and Women's Hospital
NCT03656783
N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults
Indiana University
NCT01962961
Randomized Placebo-Controlled Trial of Atorvastatin in HIV-Positive Patients Not on Antiretroviral Therapy
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00367458
Examining Hair to Determine Tenofovir Exposure
Public Health Foundation Enterprises
NCT00903084
Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)
Pennington Biomedical Research Center
NCT04794543
Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study
University of Minnesota
NCT06149624
Changes in Lipids and Safety of Raltegravir in HIV+ Patients With Hyperlipidemia While on Current Standard Therapy
The Miriam Hospital
NCT00887653
Interluekin-7 to Treat HIV-Infected People Receiving Antiretroviral Treatment
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00105417
BK Virus in Salivary Gland Disease: Treating the Potential Etiologic Agent
University of North Carolina, Chapel Hill
NCT02068846
Safety, PK, and PD Study of a Vaginal Insert Containing TAF and EVG
CONRAD
NCT03762772
Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence
Rhode Island Hospital
NCT02602795
A Phase I Study to Evaluate the Safety and Immunogenicity of Heterologous Boost Immunizations With MVA-CMDR
Rockefeller University
NCT01889719
ARCH II Study (Alcohol Research Center on HIV Study II)
University of Florida
NCT02563574
Taste Assessment Study of 2 Atazanavir Powder Formulations in Healthy Subjects
Bristol-Myers Squibb
NCT01404572
Proof of Principle Study of Pulse Dosing of IL-15 to Deplete the Reservoir in HIV Infected People
University of Minnesota
NCT02191098
A Phase 1 Trial to Evaluate CAP256V2LS in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04408963
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 32 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV Trial Landscape
304 indexed HIV studies · 109 recruiting (36%).
Phase mix: 25 late (III/IV) vs 64 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV?
PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.