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ClinicalTrials.gov 109 recruiting now official registry

HIV clinical trials

109 of 304 indexed HIV trials are currently recruiting.

304 US clinical trials · 109 currently recruiting

HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.

The research picture

HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.

109
recruiting participants now
36%
of trials open to enrollment
25
in Phase 3–4 (later-stage)
24
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 132Phase 232Phase 312Phase 413

Active & Recent Trials

304 total, page 6 of 7

COMPLETED NA 50 participants

Cognitive Behavior Therapy (CBT)-Based Group Intervention to Reduce Inflammation in Older People With HIV

Massachusetts General Hospital

NCT05434741

COMPLETED NA 50 participants

Increasing Motivation for Antiretroviral Therapy Initiation: A Pilot Intervention

University of Maryland, Baltimore

NCT02055417

COMPLETED Phase 1 49 participants

A Phase 1, Open Label, Dose-escalation Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 3BNC117

Rockefeller University

NCT02018510

COMPLETED Phase 1 46 participants

Rifaximin for Chronic Immune Activation in People With HIV

National Cancer Institute (NCI)

NCT01866826

COMPLETED NA 46 participants

Lower Extremity Splinting to Manage Pain and Sleep Disturbances Associated With HIV/AIDS Related Peripheral Neuropathy

Texas Woman's University

NCT01419314

COMPLETED NA 44 participants

Exercise and Pioglitazone for HIV-Metabolic Syndromes

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT00639457

COMPLETED Phase 1 44 participants

A Clinical Trial to Evaluate Safety, Tolerability, and Immunogenicity of Adjuvanted HIV-1 Fusion Peptide Conjugate Vaccine Alone or in Prime-Boost Regimens With Adjuvanted HIV-1 Envelope Trimer 4571 and HIV-1 Trimer 6931 Vaccines in Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT05470400

COMPLETED Phase 4 43 participants

Effect of Gender and HIV Infection on Zidovudine and Lamivudine Pharmacokinetics

University of Colorado, Denver

NCT01386970

COMPLETED Phase 2 43 participants

Development of an Empowerment Intervention for Young Women Living With HIV

University of North Carolina, Chapel Hill

NCT01454921

COMPLETED NA 42 participants

Treatment for Depression Among HIV-Infected Youth

University of North Carolina, Chapel Hill

NCT01049789

COMPLETED 40 participants

Neurocognitive Effects of Buprenorphine Among HIV+ and HIV-Opioid Users

Albert Einstein College of Medicine

NCT01108679

COMPLETED Phase 2 40 participants

Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults

University Hospitals Cleveland Medical Center

NCT01046682

COMPLETED NA 39 participants

Technology-Enhanced Peer Navigation to Improve IDUs' Engagement in HIV Care

Johns Hopkins Bloomberg School of Public Health

NCT01941108

COMPLETED Phase 1 37 participants

Safety, Tolerability, and Effect of TMC207 and Efavirenz in Healthy Volunteers

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00992069

COMPLETED Phase 4 37 participants

Validation of a Urine Assay to Measure Tenofovir Levels in Patients Taking Tenofovir Alafenamide

Philadelphia Fight

NCT03350672

COMPLETED NA 37 participants

Contingency Management in HIV Care for Both Stimulant Use & ART Adherence

University of California, San Francisco

NCT06564792

COMPLETED NA 36 participants

Adapting the Finding Respect and Ending Stigma Around HIV (FRESH) Intervention for the Dominican Republic

Florida State University

NCT04491539

COMPLETED 35 participants

PET/CT Imaging Companion Study To ACTG A5314

Massachusetts General Hospital

NCT02312219

COMPLETED Phase 1 35 participants

Safety, Pharmacokinetics and Acceptability of PC-1005 for Vaginal Use

Population Council

NCT02033109

COMPLETED NA 34 participants

Pilot Study of the Effects of Exercise on Aging Among Older Persons With HIV

University of California, San Francisco

NCT01860261

COMPLETED NA 33 participants

Strength Training and Endurance Exercise for LIFE

VA Office of Research and Development

NCT02101060

COMPLETED Phase 1 33 participants

A Study of the Safety, Pharmacokinetics and Antiretroviral Activity of 10-1074

Rockefeller University

NCT02511990

COMPLETED NA 33 participants

Improving Memory Performance by Applying Cognitive Training

Duke University

NCT02216591

COMPLETED NA 32 participants

NOLA GEM: Feasibility and Acceptability of an MHealth Intervention for Violence-affected PLWH

Tulane University

NCT05784714

COMPLETED NA 32 participants

SmartManage Stress Management for HIV+ Cancer Survivors

University of Miami

NCT04544917

COMPLETED Phase 1 31 participants

Exploring HIV Entry Blockade as a Pre-exposure Prophylaxis Strategy in Women

Emory University

NCT01749566

COMPLETED NA 30 participants

CBSM Intervention Via mHealth to Ameliorate HIV-related Fatigue

Medical University of South Carolina

NCT03149094

COMPLETED NA 30 participants

CRUSH-PrEP for Women Project

University of California, San Francisco

NCT02852226

COMPLETED Early Phase 1 30 participants

Development of a Urine-Based Point-of-Care Test for Adherence to Antiretroviral Drugs

Rhonda Brand

NCT04302896

COMPLETED 30 participants

Use of 99mTc Tilmanocept for Imaging Arterial Inflammation

Massachusetts General Hospital

NCT02542371

COMPLETED 29 participants

Impact of a Short-Term Analytical Treatment Interruption and Re-Initiation of Antiretroviral Therapy on Immunologic and Virologic Parameters in HIV-Infected Individuals

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03225118

COMPLETED NA 28 participants

Developing a Trauma-focused Intervention for Older Adults Living With HIV

University of South Carolina

NCT05287230

COMPLETED NA 27 participants

Y2Prevent: Preventing Drug Use and HIV Through Empowerment, Social Support and Mentorship (Y2P)

Children's Hospital Los Angeles

NCT04504981

COMPLETED NA 26 participants

Potential for Drug-drug Interactions Between Boceprevir and Etravirine in HIV/Hepatitis C Virus Negative Volunteers

University of Colorado, Denver

NCT01427504

COMPLETED Phase 3 25 participants

Effects of Biktarvy on CFR in Stable HIV Patients

Brigham and Women's Hospital

NCT03656783

COMPLETED Phase 1 24 participants

N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults

Indiana University

NCT01962961

COMPLETED Phase 2 24 participants

Randomized Placebo-Controlled Trial of Atorvastatin in HIV-Positive Patients Not on Antiretroviral Therapy

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00367458

COMPLETED Phase 1 24 participants

Examining Hair to Determine Tenofovir Exposure

Public Health Foundation Enterprises

NCT00903084

COMPLETED 23 participants

Effects of Using E-Cigarettes on Lungs in People With HIV (HBS Ancillary)

Pennington Biomedical Research Center

NCT04794543

COMPLETED NA 22 participants

Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study

University of Minnesota

NCT06149624

COMPLETED Phase 3 20 participants

Changes in Lipids and Safety of Raltegravir in HIV+ Patients With Hyperlipidemia While on Current Standard Therapy

The Miriam Hospital

NCT00887653

COMPLETED Phase 1 20 participants

Interluekin-7 to Treat HIV-Infected People Receiving Antiretroviral Treatment

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00105417

COMPLETED Phase 3 17 participants

BK Virus in Salivary Gland Disease: Treating the Potential Etiologic Agent

University of North Carolina, Chapel Hill

NCT02068846

COMPLETED Phase 1 16 participants

Safety, PK, and PD Study of a Vaginal Insert Containing TAF and EVG

CONRAD

NCT03762772

COMPLETED NA 14 participants

Distress Tolerance and HIV Prevention With XR-NTX Initiation in Opioid Dependence

Rhode Island Hospital

NCT02602795

COMPLETED Phase 1 14 participants

A Phase I Study to Evaluate the Safety and Immunogenicity of Heterologous Boost Immunizations With MVA-CMDR

Rockefeller University

NCT01889719

COMPLETED NA 14 participants

ARCH II Study (Alcohol Research Center on HIV Study II)

University of Florida

NCT02563574

COMPLETED Phase 1 12 participants

Taste Assessment Study of 2 Atazanavir Powder Formulations in Healthy Subjects

Bristol-Myers Squibb

NCT01404572

COMPLETED Phase 1 10 participants

Proof of Principle Study of Pulse Dosing of IL-15 to Deplete the Reservoir in HIV Infected People

University of Minnesota

NCT02191098

COMPLETED Phase 1 10 participants

A Phase 1 Trial to Evaluate CAP256V2LS in Healthy Adults

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04408963

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Phase Distribution

PhaseTrial count
Phase 1 32
Phase 2 32
Phase 3 12
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HIV Trial Landscape

304 indexed HIV studies · 109 recruiting (36%).

Phase mix: 25 late (III/IV) vs 64 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HIV?

PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HIV?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.