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HIV clinical trials
109 of 304 indexed HIV trials are currently recruiting.
304 US clinical trials · 109 currently recruiting
HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.
The research picture
HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.
- 109
- recruiting participants now
- 36%
- of trials open to enrollment
- 25
- in Phase 3–4 (later-stage)
- 24
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Active & Recent Trials
304 total, page 5 of 7
Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings
Hunter College of City University of New York
NCT02390908
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01089114
Phase IIIB Study Evaluating the Effects of Atazanavir Powder With Ritonavir in HIV-infected Pediatric Patients
Bristol-Myers Squibb
NCT01335698
Acceptability, Feasibility, and Preliminary Impact of a Web-based, HIV Prevention Toolkit With Cisgender Male Couples in Lima, Peru
Florida International University
NCT05873855
Body Image in Youth With HIV
St. Jude Children's Research Hospital
NCT01673750
Antiretroviral Therapy Selection: Comparing HIV Clinical Guidelines With HIV-ASSIST, an Online Decision-support Tool
Johns Hopkins University
NCT04080765
Transitioning HIV+ Adolescents to Adult Care: Exploring Adolescent and Adult Medicine Clinics Role in the Process
University of North Carolina, Chapel Hill
NCT02785302
An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)
University of California, Los Angeles
NCT01641146
HIV/STI Prevention Among Black Adolescents With Mental Illnesses (Project GOLD)
University of Pennsylvania
NCT03348813
Internet-based HIV/STI Prevention for Young MSM Receiving HIV Testing
University of Illinois at Chicago
NCT00968188
Suppression of HIV 1 RNA in People Living With HIV
Johns Hopkins University
NCT02363387
EPIC-P Intervention
University of Connecticut
NCT04193787
Neurocognitive Effects and Tolerability of Efavirenz in Aging HIV-infected Individuals ("SHAC Neuro Study")
Stanford University
NCT01985399
A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01172535
Health Improvement for Baltimore Youth
Johns Hopkins University
NCT02624193
Positive Lifestyles Using Safety
Yale University
NCT00836290
Diet / Gut Microbiome Interaction and Influence on Inflammatory Disease in HIV Patients
University of Colorado, Denver
NCT02610374
Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication
University of Maryland, Baltimore
NCT03823911
To Reach Unrestricted Services for Transgender Women
University of Central Florida
NCT03877497
Effects of Mindfulness Training on Chronic Inflammation in HIV-Infected Adults
Icahn School of Medicine at Mount Sinai
NCT02626949
ARV Concentrations in Hair
University of North Carolina, Chapel Hill
NCT02768779
Determine the Prevalence and Severity of Asthma in HIV (Human Immunodeficiency Virus) Infected Patients
Duke University
NCT02405026
A Pilot Intervention to Improve Coping With Discrimination and Adherence Among HIV-Positive Latino MSM
RAND
NCT03432819
MyPEEPS Mobile for Young Transgender Men
Columbia University
NCT05424718
Mobile Health Application to Improve HIV Medication Adherence
Rhode Island Hospital
NCT02676128
American Indian and Alaska Native Men Who Have Sex With Men HIV & Substance Abuse Research
University of Washington
NCT03049904
Efficacy and Safety of E/C/F/TAF (Genvoya®) in HIV-1/Hepatitis B Co-infected Adults
Gilead Sciences
NCT02071082
Onboarding Positives and PrEP Users to Engage Negatives (OPPEN): Peer-driven Education to Link YMSM of Color to PrEP
University of California, San Diego
NCT05356910
Use of EndoPAT for Measurements of Endothelial Dysfunction in HIV Infected Children and Healthy Controls
University Hospitals Cleveland Medical Center
NCT02324179
Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening
University of Michigan
NCT06100250
Effects of CYP2B6 Genetic Polymorphisms on Efavirenz Pharmacokinetics
Indiana University
NCT00668395
Study of the Safety and Efficacy of Stribild Versus Atripla in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
Gilead Sciences
NCT00869557
Pre-Exposure Prophylaxis in YMSM
University of North Carolina, Chapel Hill
NCT01033942
Evaluating a Real-Time, Remote Monitoring System for Home-Based HIV Testing
Brown University
NCT02876926
Preparing for Pharmacy-based Delivery of Long-acting Injectable Antiretroviral Therapy (LAI-ART)
University of California, San Francisco
NCT05152953
Cell Phone Technology Targeting ART Adherence and Drug Use
University of California, Los Angeles
NCT01884233
Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)
Yale University
NCT00798538
Impact of Hormonal Contraception on HIV Acquisition and Transmission Risk
Lisa Haddad
NCT02357368
Antiplatelet Therapy in HIV
NYU Langone Health
NCT02559414
Efficacy of Tenofovir Alafenamide Versus Placebo Added to a Failing Regimen Followed by Treatment With Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Atazanavir in HIV-1 Positive, Antiretroviral Treatment-Experienced Adults
Gilead Sciences
NCT01967940
A Two Year Study of the Clinical Efficacy of the Combination of Emtricitabine, Tenofovir, and Nevirapine
University of Maryland, Baltimore
NCT00344461
Evaluating Factors That Impact Loss to Follow-up Among Postpartum HIV-infected Women in Mississippi
University of Mississippi Medical Center
NCT01190605
Contingency Management for Methamphetamine Abstinence and HIV Post-Exposure Prophylaxis in Men Who Have Sex With Men
Friends Research Institute
NCT00856323
Relationship of Exercise, Sleep, and Inflammation Markers in People Living With HIV
Christine Horvat Davey
NCT04946994
Eliminating Hepatitis C Virus
Icahn School of Medicine at Mount Sinai
NCT03401697
Zinc Supplementation and Cardiovascular Risk in HIV
Grace McComsey
NCT02856269
PrEP With TDF/FTC to Prevent HIV-1 Acquisition in Young MSM and Transgender Women of Color
Philadelphia Fight
NCT02367807
Development of Adherence Biomarkers for Multiple Microbicide and Multipurpose Prevention Technology (MPT) Dosage Forms
CONRAD
NCT02569697
Intervention for Newly Diagnosed Youth With HIV
University of North Carolina, Chapel Hill
NCT00510237
Health Improvement Project - Providence
The Miriam Hospital
NCT02886234
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 32 |
| Phase 2 | 32 |
| Phase 3 | 12 |
| Phase 4 | 13 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the HIV Trial Landscape
304 indexed HIV studies · 109 recruiting (36%).
Phase mix: 25 late (III/IV) vs 64 early (I/II).
Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for HIV?
PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for HIV?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.