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ClinicalTrials.gov 109 recruiting now official registry

HIV clinical trials

109 of 304 indexed HIV trials are currently recruiting.

304 US clinical trials · 109 currently recruiting

HIV is the subject of 304 registered US clinical trials on ClinicalTrials.gov, 109 of them currently open to new participants. 25 are in Phase 3-4 (later-stage) and 64 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute of Allergy and Infectious Diseases (NIAID), running 24 of these trials.

The research picture

HIV has 304 registered US clinical trials, 109 of them open to new participants right now, about 36% of the total.

109
recruiting participants now
36%
of trials open to enrollment
25
in Phase 3–4 (later-stage)
24
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Phase 132Phase 232Phase 312Phase 413

Active & Recent Trials

304 total, page 5 of 7

COMPLETED NA 174 participants

Improving HIV and Alcohol-Related Outcomes Among HIV+ Persons in Clinic Settings

Hunter College of City University of New York

NCT02390908

COMPLETED 168 participants

Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01089114

COMPLETED Phase 3 160 participants

Phase IIIB Study Evaluating the Effects of Atazanavir Powder With Ritonavir in HIV-infected Pediatric Patients

Bristol-Myers Squibb

NCT01335698

COMPLETED NA 148 participants

Acceptability, Feasibility, and Preliminary Impact of a Web-based, HIV Prevention Toolkit With Cisgender Male Couples in Lima, Peru

Florida International University

NCT05873855

COMPLETED 146 participants

Body Image in Youth With HIV

St. Jude Children's Research Hospital

NCT01673750

COMPLETED NA 138 participants

Antiretroviral Therapy Selection: Comparing HIV Clinical Guidelines With HIV-ASSIST, an Online Decision-support Tool

Johns Hopkins University

NCT04080765

COMPLETED 136 participants

Transitioning HIV+ Adolescents to Adult Care: Exploring Adolescent and Adult Medicine Clinics Role in the Process

University of North Carolina, Chapel Hill

NCT02785302

COMPLETED Phase 2 118 participants

An HIV Intervention for Black Men at Risk - The Enhanced Sexual Health Intervention for Men (ES-HIM)

University of California, Los Angeles

NCT01641146

COMPLETED NA 108 participants

HIV/STI Prevention Among Black Adolescents With Mental Illnesses (Project GOLD)

University of Pennsylvania

NCT03348813

COMPLETED NA 102 participants

Internet-based HIV/STI Prevention for Young MSM Receiving HIV Testing

University of Illinois at Chicago

NCT00968188

COMPLETED NA 102 participants

Suppression of HIV 1 RNA in People Living With HIV

Johns Hopkins University

NCT02363387

COMPLETED NA 100 participants

EPIC-P Intervention

University of Connecticut

NCT04193787

COMPLETED 100 participants

Neurocognitive Effects and Tolerability of Efavirenz in Aging HIV-infected Individuals ("SHAC Neuro Study")

Stanford University

NCT01985399

COMPLETED Phase 2 97 participants

A Phase II/III Trial of Lopinavir/Ritonavir Dosed According to the WHO Pediatric Weight Band Dosing Guidelines

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01172535

COMPLETED NA 97 participants

Health Improvement for Baltimore Youth

Johns Hopkins University

NCT02624193

COMPLETED NA 90 participants

Positive Lifestyles Using Safety

Yale University

NCT00836290

COMPLETED NA 90 participants

Diet / Gut Microbiome Interaction and Influence on Inflammatory Disease in HIV Patients

University of Colorado, Denver

NCT02610374

COMPLETED Phase 4 87 participants

Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C Eradication

University of Maryland, Baltimore

NCT03823911

COMPLETED NA 86 participants

To Reach Unrestricted Services for Transgender Women

University of Central Florida

NCT03877497

COMPLETED NA 84 participants

Effects of Mindfulness Training on Chronic Inflammation in HIV-Infected Adults

Icahn School of Medicine at Mount Sinai

NCT02626949

COMPLETED 84 participants

ARV Concentrations in Hair

University of North Carolina, Chapel Hill

NCT02768779

COMPLETED 83 participants

Determine the Prevalence and Severity of Asthma in HIV (Human Immunodeficiency Virus) Infected Patients

Duke University

NCT02405026

COMPLETED NA 82 participants

A Pilot Intervention to Improve Coping With Discrimination and Adherence Among HIV-Positive Latino MSM

RAND

NCT03432819

COMPLETED NA 80 participants

MyPEEPS Mobile for Young Transgender Men

Columbia University

NCT05424718

COMPLETED NA 80 participants

Mobile Health Application to Improve HIV Medication Adherence

Rhode Island Hospital

NCT02676128

COMPLETED NA 79 participants

American Indian and Alaska Native Men Who Have Sex With Men HIV & Substance Abuse Research

University of Washington

NCT03049904

COMPLETED Phase 3 79 participants

Efficacy and Safety of E/C/F/TAF (Genvoya®) in HIV-1/Hepatitis B Co-infected Adults

Gilead Sciences

NCT02071082

COMPLETED NA 78 participants

Onboarding Positives and PrEP Users to Engage Negatives (OPPEN): Peer-driven Education to Link YMSM of Color to PrEP

University of California, San Diego

NCT05356910

COMPLETED 76 participants

Use of EndoPAT for Measurements of Endothelial Dysfunction in HIV Infected Children and Healthy Controls

University Hospitals Cleveland Medical Center

NCT02324179

COMPLETED NA 75 participants

Zenyth: Motivational Interviewing-based Telehealth Intervention for Bacterial Sexually Transmitted Infection Screening

University of Michigan

NCT06100250

COMPLETED NA 73 participants

Effects of CYP2B6 Genetic Polymorphisms on Efavirenz Pharmacokinetics

Indiana University

NCT00668395

COMPLETED Phase 2 71 participants

Study of the Safety and Efficacy of Stribild Versus Atripla in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults

Gilead Sciences

NCT00869557

COMPLETED Phase 2 68 participants

Pre-Exposure Prophylaxis in YMSM

University of North Carolina, Chapel Hill

NCT01033942

COMPLETED NA 65 participants

Evaluating a Real-Time, Remote Monitoring System for Home-Based HIV Testing

Brown University

NCT02876926

COMPLETED 63 participants

Preparing for Pharmacy-based Delivery of Long-acting Injectable Antiretroviral Therapy (LAI-ART)

University of California, San Francisco

NCT05152953

COMPLETED NA 62 participants

Cell Phone Technology Targeting ART Adherence and Drug Use

University of California, Los Angeles

NCT01884233

COMPLETED Phase 4 60 participants

Integration of Buprenorphine Into HIV Clinical Settings - Primary Care Model (PCM)

Yale University

NCT00798538

COMPLETED Phase 4 59 participants

Impact of Hormonal Contraception on HIV Acquisition and Transmission Risk

Lisa Haddad

NCT02357368

COMPLETED Phase 2 55 participants

Antiplatelet Therapy in HIV

NYU Langone Health

NCT02559414

COMPLETED Phase 3 55 participants

Efficacy of Tenofovir Alafenamide Versus Placebo Added to a Failing Regimen Followed by Treatment With Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Plus Atazanavir in HIV-1 Positive, Antiretroviral Treatment-Experienced Adults

Gilead Sciences

NCT01967940

COMPLETED Phase 4 54 participants

A Two Year Study of the Clinical Efficacy of the Combination of Emtricitabine, Tenofovir, and Nevirapine

University of Maryland, Baltimore

NCT00344461

COMPLETED 53 participants

Evaluating Factors That Impact Loss to Follow-up Among Postpartum HIV-infected Women in Mississippi

University of Mississippi Medical Center

NCT01190605

COMPLETED Phase 2 53 participants

Contingency Management for Methamphetamine Abstinence and HIV Post-Exposure Prophylaxis in Men Who Have Sex With Men

Friends Research Institute

NCT00856323

COMPLETED NA 53 participants

Relationship of Exercise, Sleep, and Inflammation Markers in People Living With HIV

Christine Horvat Davey

NCT04946994

COMPLETED 52 participants

Eliminating Hepatitis C Virus

Icahn School of Medicine at Mount Sinai

NCT03401697

COMPLETED NA 52 participants

Zinc Supplementation and Cardiovascular Risk in HIV

Grace McComsey

NCT02856269

COMPLETED 50 participants

PrEP With TDF/FTC to Prevent HIV-1 Acquisition in Young MSM and Transgender Women of Color

Philadelphia Fight

NCT02367807

COMPLETED Phase 1 50 participants

Development of Adherence Biomarkers for Multiple Microbicide and Multipurpose Prevention Technology (MPT) Dosage Forms

CONRAD

NCT02569697

COMPLETED NA 50 participants

Intervention for Newly Diagnosed Youth With HIV

University of North Carolina, Chapel Hill

NCT00510237

COMPLETED NA 50 participants

Health Improvement Project - Providence

The Miriam Hospital

NCT02886234

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Phase Distribution

PhaseTrial count
Phase 1 32
Phase 2 32
Phase 3 12
Phase 4 13

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the HIV Trial Landscape

304 indexed HIV studies · 109 recruiting (36%).

Phase mix: 25 late (III/IV) vs 64 early (I/II).

Top sponsor: National Institute of Allergy and Infectious Diseases (NIAID) (24 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for HIV?

PlainTrial tracks 304 US clinical trials for HIV, of which 109 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for HIV?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.