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Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer
NCT05775159 · View on ClinicalTrials.gov ↗
Study Summary
GEMINI-Hepatobiliary study will assess the efficacy, safety and tolerability of novel immunomodulators alone and in combination with other anticancer drugs in participants with specified advanced solid tumors.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Gemcitabine
- DRUG Rilvegostomig
- DRUG Lenvatinib
- DRUG Volrustomig
Study Locations (20)
Other
- Research Site — Beijing
- Research Site — Beijing
- Research Site — Beijing
- Research Site — Chengdu
- Research Site — Chengdu
- Research Site — Chongqing
- Research Site — Fuzhou
- Research Site — Guangzhou
- Research Site — Guangzhou
- Research Site — Harbin
California
- Research Site — Costa Mesa
- Research Site — Los Angeles
- Research Site — Orange
Alabama
- Research Site — Birmingham
Florida
- Research Site — Miami Beach
Indiana
- Research Site — Dyer
Kansas
- Research Site — Kansas City
New York
- Research Site — New York
Texas
- Research Site — Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 294 participants |
| Start Date | 2023-04-24 |
| Est. Completion | 2027-10-28 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05775159
The ClinicalTrials.gov registry entry for NCT05775159 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 294 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Hepatocellular Carcinoma appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05775159 reports 20 study locations spanning 9 distinct geographic areas — top geographies include Other, California, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05775159 about?
NCT05775159 is a clinical study titled "Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer". GEMINI-Hepatobiliary study will assess the efficacy, safety and tolerability of novel immunomodulators alone and in combination with other anticancer drugs in participants with specified advanced solid tumors.
What is the current status of trial NCT05775159?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 294 participants. The study started on 2023-04-24. Estimated completion is 2027-10-28.
What conditions does trial NCT05775159 study?
This clinical trial studies the following conditions: Hepatocellular Carcinoma, Biliary Tract Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05775159?
The interventions under investigation include: Bevacizumab (DRUG), Gemcitabine (DRUG), Rilvegostomig (DRUG), Lenvatinib (DRUG), Volrustomig (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05775159?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05775159 being conducted?
This trial has 20 study locations across Alabama, California, Florida, Indiana, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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