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Heart Failure: full-pipeline trial registry
164 of 399 indexed Heart Failure trials are currently recruiting.
Corpus placement: #13 of 28,963 conditions by registered trial count.
399 US clinical trials · 164 currently recruiting · #13 of 28,963 conditions by registered trial count
Heart Failure: 399 US clinical trials tracked, 164 recruiting.
Heart Failure is the subject of 399 registered US clinical trials on ClinicalTrials.gov, 164 of them currently open to new participants. 47 are in Phase 3-4 (later-stage) and 63 in Phase 1-2 (earlier-stage). The most active sponsor is Abbott Medical Devices, running 15 of these trials.
Open enrollment snapshot
Heart Failure has 399 registered US clinical trials, 164 of them open to new participants right now, about 41% of the total.
- 164
- recruiting participants now
- 41%
- of trials open to enrollment
- 47
- in Phase 3-4 (later-stage)
- 15
- top sponsor: Abbott Medical Devices
Corpus placement: #13 of 28,963 conditions by registered trial count on ClinicalTrials.gov-derived indexes. Registry reference only, not medical advice.
Key findings
What ClinicalTrials.gov does not surface for Heart Failure on its own pages , computed from the registry mirror as of 2026-07-11. Each line carries its own denominator so it can be quoted as it stands.
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Heart Failure is recruiting above its size-band peers.
164 of 399 indexed trials (41.1%) are open to enrollment, against a 37.2% average across 135 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Failure trials is spread across many organizations.
Abbott Medical Devices accounts for 15 of 399 trials (3.8%). 195 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Failure enrolment sits around 128 participants.
Median target enrolment is 128 among the 398 trials that report a genuine target (sentinel values excluded). 177 of those (44.5%) plan for fewer than 100 participants.
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Heart Failure research is mostly interventional.
297 interventional and 102 observational studies make up this index (74.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
399 total, page 6 of 8
Clinical Evaluation of the Physiological Diagnosis Function in the PARADYM CRT Device
LivaNova
NCT02167789
COPILOT-HF: Cooperative Program for ImpLementation of Optimal Therapy in Heart Failure
Brigham and Women's Hospital
NCT05734690
Quartet 1457Q Left Ventricular (LV) Lead Investigational Device Exemption (IDE) Study
Abbott Medical Devices
NCT02548455
ECG Belt for CRT Response
Medtronic Cardiac Rhythm and Heart Failure
NCT03504020
Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy
Abbott Medical Devices
NCT01121107
Phase IIb Safety and Efficacy Study of Four Dose Regimens of BAY1021189 in Patients With Heart Failure With Reduced Ejection Fraction Suffering From Worsening Chronic Heart Failure (SOCRATES-REDUCED)
Bayer
NCT01951625
PROSPECT: Predictors of Response to Cardiac Re-Synchronization Therapy
Medtronic Cardiac Rhythm and Heart Failure
NCT00253357
PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device
University of Colorado, Denver
NCT02344576
Reducing Decompensation Events Utilizing Intracardiac Pressures in Patients With Chronic Heart Failure (HF) (REDUCEhf)
Medtronic Cardiac Rhythm and Heart Failure
NCT00354159
Conduction System Pacing International Registry (CONSPIRE)
University of Chicago
NCT04831125
Impact of a Psychological Biofeedback-Relaxation Intervention on Clinical, Physical and Psychological Outcomes in Patients With Heart Failure
University of Kentucky
NCT00255931
ECG AI-Guided Screening for Low Ejection Fraction
Mayo Clinic
NCT04000087
CHF Inpatient Ambulation Trial
Lancaster General Hospital
NCT02828553
STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)
Massachusetts General Hospital
NCT02943590
Cognitive Problems in Veterans With Heart Failure
US Department of Veterans Affairs
NCT01049308
Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety
Massachusetts General Hospital
NCT03118752
Same Day Discharge (SDD) After Implantable Cardioverter Defibrillator (ICD) Implant
Abbott Medical Devices
NCT01993862
InSync III Marquis Model 7279 Cardioverter Defibrillator Cardiac Resynchronization System
Medtronic Cardiac Rhythm and Heart Failure
NCT00271232
Palliative Care for Heart Failure Patients
Allina Health System
NCT01519479
Genomic Response Analysis of Heart Failure Therapy in African Americans
University of Pittsburgh
NCT02305095
The Impact of an Adaptive Patient-centered Web Application on Medication Optimization in HFrEF Patients
University of Michigan
NCT05858320
RISK Stratification Using a Combination of Cardiac Troponin T and Brain Natriuretic Peptide in Patients Receiving CRT-D
Abbott Medical Devices
NCT00453622
Testing the Effects of Telehealth Monitoring on Rehospitalization and Self Care for Heart Failure Patients in Home Care
University of Pennsylvania
NCT00300261
LINK-HF2 - Remote Monitoring Analytics in Heart Failure
VA Office of Research and Development
NCT04502563
Ablation vs Amiodarone for Treatment of AFib in Patients With CHF and an ICD
Texas Cardiac Arrhythmia Research Foundation
NCT00729911
Prospective Aerobic Reconditioning Intervention Study
Wake Forest University
NCT01113840
Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device (LVAD) and Medical Management
Abbott Medical Devices
NCT01452802
The Prevalence and Risk Factors of Sleep Disordered Breathing in a Heart Failure Program
Ohio State University
NCT00679822
Insomnia Self-Management in Heart Failure
Yale University
NCT02660385
Cardiac Recovery Through Dietary Support
University of California, San Francisco
NCT03759925
Quality IQ Patient Simulation Physician Practice Measurement and Engagement
Qure Healthcare
NCT03800901
Effect of Targeted Interventions to Improve Value Based Health Care for Inpatient Cardiology Patients
Vanderbilt University Medical Center
NCT03173157
Helping Others Toward Positive Emotions in People With Heart Failure
Rebecca L. Dekker, PhD, RN, APRN
NCT01275742
Remote Physician Care for Home Hospital Patients
Brigham and Women's Hospital
NCT04080570
Medical Arm of the Interagency Registry for Mechanically Assisted Circulatory Support
National Heart, Lung, and Blood Institute (NHLBI)
NCT01932294
Education and Supportive Partners Improving Self-Care (ENSPIRE)
Emory University
NCT00166049
Extension Phase of the Chronicle® Offers Management to Patients With Advanced Signs & Symptoms of Heart Failure Study
Medtronic Cardiac Rhythm and Heart Failure
NCT00991120
Detect Fluid Early From Intra-thoracic Impedance Monitoring
Abbott Medical Devices
NCT00916929
Depression and Self-care in Heart Failure
Washington University School of Medicine
NCT01028625
Outlook: An Intervention to Improve Quality of Life in Serious Illness
Duke University
NCT00939146
Depression and Congestive Heart Failure in Outpatients.
VA Office of Research and Development
NCT00321269
Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care
University of Illinois at Chicago
NCT01005602
Randomized Study of Organ Care System Cardiac for Preservation of Donated Hearts for Eventual Transplantation
TransMedics
NCT00855712
Safety and Efficacy of Automatic Testing Feature in New ICDs and CRT-Ds
Abbott Medical Devices
NCT00746356
Evaluation of Patiromer in Heart Failure Patients
Relypsa
NCT00868439
Effect of Behavioral Management on Quality of Life in Heart Failure
US Department of Veterans Affairs
NCT00012870
EASYTRAK 4 Steerable LV Lead
Boston Scientific Corporation
NCT00158964
Necklace-Shaped Sensor for Non-Invasive Remote Monitoring of Vitals
Baxter Healthcare Corporation
NCT02337790
Cardio-pulmonary Rehabilitation and Sleep Quality
MetroHealth Medical Center
NCT04668599
Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF
Adrian Hernandez
NCT02742129
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 28 |
| Phase 2 | 35 |
| Phase 3 | 24 |
| Phase 4 | 23 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
What is open for Heart Failure right now
164 recruiting of 399 indexed (41% open).
Phase mix: 47 late (III/IV) vs 63 early (I/II) (balanced across stages).
Top sponsor: Abbott Medical Devices (15 trials), 9 others listed. 50 shown below, recruiting first. #13 of 28,963 conditions by registered trial count.
How open-enrollment share is computed
Open share is recruiting_count divided by trial_count for this condition label in the public registry export. Status can change between pulls; treat the figure as a snapshot of research attention, not treatment availability.
Frequently Asked Questions
How many clinical trials are there for Heart Failure?
PlainTrial tracks 399 US clinical trials for Heart Failure, of which 164 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Failure?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.