Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT02742129 · ClinicalTrials.gov registry record · Phase 2
Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF
A Phase 2 study of Heart Failure, sponsored by Adrian Hernandez.
- Completed
- Registry status
- Phase 2
- Development phase
- 105
- Enrollment target
- 20
- Study locations
NCT02742129: Completed Phase 2 study of Heart Failure, sponsored by Adrian Hernandez.
NCT02742129 is a Phase 2 study of Heart Failure that has completed, run by Adrian Hernandez. The registered enrollment target is 105 participants, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (95% lower). The trial reports 20 study locations across 11 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02742129, a Phase 2 study of Heart Failure, has completed, sponsored by Adrian Hernandez.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 105 participants
- Enrollment target
- 20
- Study locations
Study Summary
A randomized, double-blind, placebo-controlled crossover study to assess the effect of inorganic nitrite (NO2) on aerobic capacity (peak VO2) after four weeks of dosing. Approximately 100 participants will be enrolled in this 2\*2 crossover study.
Primary Outcome
The primary endpoint will be the peak VO2 after 4 weeks treatment with inorganic nitrite as compared to the peak VO2 after 4 weeks treatment with placebo as assessed by cardiopulmonary exercise testing (CPET) performed at peak drug levels.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Nebulized Sodium Nitrite
Study Locations (20)
Massachusetts
- Tufts Medical Center - Boston
- Massachusetts General Hospital - Boston
- Brigham and Women's Hospital - Boston
- Boston V.A. Healthcare System - West Roxbury
Missouri
- University of Missouri Health System - Columbia
- V.A St. Louis Health Care System - St Louis
- Washington University School of Medicine - St Louis
Ohio
- University Hospitals Cleveland Medical Center - Cleveland
- Metro Health System - Cleveland
- Cleveland Clinic Foundation - Cleveland
Pennsylvania
- Abington Memorial Hospital - Abington
- University of Pennsylvania Health System - Philadelphia
- Jefferson Medical College - Philadelphia
Georgia
- Emory University School of Medicine - Atlanta
Illinois
- Northwestern University - Chicago
Maryland
- Johns Hopkins Hospital - Baltimore
Minnesota
- Mayo Clinic - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2016-08-10 |
| Est. Completion | 2017-12-27 |
| Phase | Phase 2 |
What the finished NCT02742129 record still lists
NCT02742129 is an interventional study that assigns participants to a tested intervention. The registered 105 participants enrollment target is mid-sized for trials with a published cap, below the 2,049-participant average among 397 other Heart Failure trials with a reported enrollment target (95% lower).
The record links to 1 condition, with Heart Failure appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT02742129 names 20 study sites across 11 states, led by Massachusetts, Missouri, Ohio.
Frequently Asked Questions
What is clinical trial NCT02742129 about?
NCT02742129 is a clinical study titled "Inorganic Nitrite Delivery to Improve Exercise Capacity in HFpEF". A randomized, double-blind, placebo-controlled crossover study to assess the effect of inorganic nitrite (NO2) on aerobic capacity (peak VO2) after four weeks of dosing. Approximately 100 participants will be enrolled in this 2\*2 crossover study.
What is the current status of trial NCT02742129?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 105 participants. The study started on 2016-08-10. Estimated completion is 2017-12-27.
What conditions does trial NCT02742129 study?
This clinical trial studies the following conditions: Heart Failure.
What interventions are being tested in trial NCT02742129?
The interventions under investigation include: Placebo (DRUG), Nebulized Sodium Nitrite (DRUG).
Who is sponsoring clinical trial NCT02742129?
This trial is sponsored by Adrian Hernandez, which has 7 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02742129 being conducted?
This trial has 20 study locations across Georgia, Illinois, Maryland, Massachusetts, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Heart Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02742129's enrollment target sits among peer trials
105 209th of 397 higher than 187 of 397 other Heart Failure trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Heart Failure trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
RECRUITING · Phase 2
-
Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial
RECRUITING · Phase 2
-
Study to Evaluate Safety, Tolerability and Drug Levels of BMS-986435/MYK-224 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
RECRUITING · Phase 2
-
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
RECRUITING · Phase 2
-
Metformin for Pulmonary Hypertension HFpEF
RECRUITING · Phase 2
-
The Inorganic Nitrate and eXercise Performance in Heart Failure (iNIX-HF)
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03372317 · 105 participants
Tau PET in Imaging and Cognition: Healthy Adults From 55-90
- NCT04253964 · 105 participants · Phase 2
Pilot Study of Performance Status 2 vs. Performance Status 0-1 Non-small Cell Lung Cancer Patients Treated With Chemo/Immunotherapy
- NCT04742452 · 105 participants · NA
Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears
- NCT04875429 · 105 participants · NA
Zenith® Fenestrated+ Clinical Study
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI