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NCT05990296 · ClinicalTrials.gov registry record · NA

Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care

A NA study of Heart Failure and Heart Failure With Reduced Ejection Fraction, sponsored by Geisinger Clinic.

Completed
Registry status
NA
Development phase
4,306
Enrollment target
1
Study location

NCT05990296 is a NA study of Heart Failure and Heart Failure With Reduced Ejection Fraction that has completed, run by Geisinger Clinic. The registered enrollment target is 4,306 participants, above the 2,038-participant average among 397 other Heart Failure trials with a reported enrollment target (111% higher). The trial reports 1 study location across 1 state.

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The verdict

NCT05990296, a NA study of Heart Failure and Heart Failure With Reduced Ejection Fraction, has completed, sponsored by Geisinger Clinic.

COMPLETED
Registry status
NA
Development phase
4,306 participants
Enrollment target
1
Study location

Study Summary

Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life. Despite convincing data that evidenced-based, guideline-directed medical therapies (GDMT) improve mortality and heart failure-related events, there remains insufficient utilization of these life-saving drugs (evidence-based beta-blockers (EBBB), angiotensin-neprilysin inhibitors (ARNI)/ angiotensin converting enzyme inhibitors (ACEi)/ angiotensin receptor blockers (ARB), mineralocorticoid receptor antagonists (MRA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with HFrEF. The primary objective of this study is to implement and evaluate a multifaceted, interdisciplinary intervention to improve GDMT use, reduce mortality, and reduce future heart failure events in patients with HFrEF.

Conditions Studied

Heart Failure Heart Failure With Reduced Ejection Fraction

Interventions

  • BEHAVIORAL Multiprong CDS with referral to pharmacist co-management
  • BEHAVIORAL Multiprong CDS with GDMT order set
  • BEHAVIORAL Focused education

Study Locations (1)

Pennsylvania

  • Geisinger Cardiology Clinics - Danville

Trial Details

FieldValue
Enrollment Target 4,306 participants
Start Date 2023-08-01
Est. Completion 2025-05-17
Phase NA

Sponsor

Geisinger Clinic

107 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05990296

The ClinicalTrials.gov registry entry for NCT05990296 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 4,306 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 2,038-participant average among 397 other Heart Failure trials with a reported enrollment target (111% higher). The listed sponsor is Geisinger Clinic, which has 107 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Heart Failure appearing as the primary indexed condition, and to 3 interventions - of which Multiprong CDS with referral to pharmacist co-management is the first listed.

NCT05990296 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT05990296 about?

NCT05990296 is a clinical study titled "Evaluating Strategies to Improve Guideline Directed Medical Therapy: The GDMT Research, Education & Assist Trial for Heart Failure Care". Heart failure with reduced ejection fraction (HFrEF) is associated with high mortality and adverse events (hospitalization or urgent outpatient visits for HF), along with diminished quality of life. Despite convincing data that evidenced-based, guideline-directed medical therapies (GDMT) improve mor...

What is the current status of trial NCT05990296?

This trial is currently completed. It is a NA study. The enrollment target is 4,306 participants. The study started on 2023-08-01. Estimated completion is 2025-05-17.

What conditions does trial NCT05990296 study?

This clinical trial studies the following conditions: Heart Failure, Heart Failure With Reduced Ejection Fraction.

What interventions are being tested in trial NCT05990296?

The interventions under investigation include: Multiprong CDS with referral to pharmacist co-management (BEHAVIORAL), Multiprong CDS with GDMT order set (BEHAVIORAL), Focused education (BEHAVIORAL).

Who is sponsoring clinical trial NCT05990296?

This trial is sponsored by Geisinger Clinic, which has 107 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05990296 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.