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EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)
NCT03057977 · View on ClinicalTrials.gov ↗
Study Summary
The aim of the study is to investigate the safety and efficacy of empagliflozin versus placebo on top of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Empagliflozin
Study Locations (20)
Florida
- Integrated Heart Care — Boca Raton
- Morton Plant Mease Health Care — Clearwater
- Nature Coast Clinical Research — Crystal River
- Avail Clinical Research, LLC — DeLand
- Holy Cross Hospital — Fort Lauderdale
- Integrative Research Associates — Fort Lauderdale
- Nature Coast Clinical Research — Inverness
- East Coast Institute for Research, LLC — Jacksonville
- Jacksonville Center for Clinical Research — Jacksonville
- Cardiovascular Research Center of South Florida — Miami
California
- La Mesa Cardiac Center — La Mesa
- Long Beach Center for Clinical Research — Long Beach
- VA Greater Los Angeles Healthcare System — Los Angeles
- Merced Vein and Vascular Center — Merced
- University of California Irvine — Orange
- Covigilant Research, LLC — Riverside
- University of California — Torrance
- Orange County Research Center — Tustin
- Blue Coast Cardiology — Vista
Colorado
- South Denver Cardiology Associates, PC — Littleton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,730 participants |
| Start Date | 2017-03-06 |
| Est. Completion | 2020-05-28 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03057977
The ClinicalTrials.gov registry entry for NCT03057977 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 3,730 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Boehringer Ingelheim, which has 203 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Heart Failure appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03057977 reports 20 study locations spanning 3 distinct geographic areas — top geographies include Florida, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03057977 about?
NCT03057977 is a clinical study titled "EMPagliflozin outcomE tRial in Patients With chrOnic heaRt Failure With Reduced Ejection Fraction (EMPEROR-Reduced)". The aim of the study is to investigate the safety and efficacy of empagliflozin versus placebo on top of guideline-directed medical therapy in patients with heart failure with reduced ejection fraction.
What is the current status of trial NCT03057977?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 3,730 participants. The study started on 2017-03-06. Estimated completion is 2020-05-28.
What conditions does trial NCT03057977 study?
This clinical trial studies the following conditions: Heart Failure. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03057977?
The interventions under investigation include: Placebo (DRUG), Empagliflozin (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03057977?
This trial is sponsored by Boehringer Ingelheim, which has 203 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03057977 being conducted?
This trial has 20 study locations across California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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