Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 26 recruiting now official registry

Heart Diseases clinical trials

26 of 86 indexed Heart Diseases trials are currently recruiting.

86 US clinical trials · 26 currently recruiting

Heart Diseases is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 26 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is National Heart, Lung, and Blood Institute (NHLBI), running 7 of these trials.

The research picture

Heart Diseases has 86 registered US clinical trials, 26 of them open to new participants right now, about 30% of the total.

26
recruiting participants now
30%
of trials open to enrollment
11
in Phase 3–4 (later-stage)
7
top sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Phase 27Phase 39Phase 42

Active & Recent Trials

86 total, page 2 of 2

COMPLETED 750 participants

CV Disease in Adolescents With Type 2 Diabetes

Children's Hospital Medical Center, Cincinnati

NCT00114998

COMPLETED 715 participants

Heart Rate Variability and Sudden Cardiac Death

Columbia University

NCT00005235

COMPLETED NA 670 participants

Physician Uncertainty Reduction for Hypertension

Baylor College of Medicine

NCT00201084

COMPLETED 650 participants

Comparison of Two Methods to Diagnose Coronary Artery Disease

Johns Hopkins University

NCT00063531

COMPLETED 586 participants

Developing and Testing a Personalized Evidence-based Shared Decision-making Tool for Stent Selection

University of Missouri, Kansas City

NCT02046902

COMPLETED 552 participants

HUDDLE: Heart Health: Understanding & Diagnosing Disease by Leveraging Echocardiograms

Edwards Lifesciences

NCT05009589

COMPLETED NA 422 participants

Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal

Windber Research Institute

NCT01805492

COMPLETED Phase 2 389 participants

Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery

Duke University

NCT00041392

COMPLETED 349 participants

Pain Assessment, Incidence & Nature in Heart Failure

PC-HEART

NCT00444301

COMPLETED 324 participants

Plaque Inflammation and Dysfunctional HDL in AIM-HIGH

University of Washington

NCT00880178

COMPLETED 320 participants

Multidisciplinary Study of Right Ventricular Dysplasia

University of Arizona

NCT00024505

COMPLETED Phase 2 309 participants

Estrogen, HDL, and Coronary Heart Disease in Women

Tufts University

NCT00083824

COMPLETED Phase 2 261 participants

Effects of Resistance and Aerobic Exercise on Cardiovascular Health

Duke University

NCT00275145

COMPLETED NA 250 participants

Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation

Baylor Research Institute

NCT00224809

COMPLETED NA 223 participants

Virtual AppLication-supported ENvironment To INcrease Exercise During Cardiac Rehabilitation Study

University of Michigan

NCT04587882

COMPLETED 210 participants

Epidemiology of Hypertensive Emergency

Columbia University

NCT00005240

COMPLETED Phase 3 200 participants

Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle

National Heart, Lung, and Blood Institute (NHLBI)

NCT00001891

COMPLETED NA 183 participants

Effect of Targeted Interventions to Improve Value Based Health Care for Inpatient Cardiology Patients

Vanderbilt University Medical Center

NCT03173157

COMPLETED NA 170 participants

Sapphire 3 CTO Study

OrbusNeich

NCT06358508

COMPLETED NA 167 participants

Strong People Strength Training Study

Cornell University

NCT04203563

COMPLETED 167 participants

Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers

University of Miami

NCT00253682

COMPLETED Phase 3 120 participants

Comparison of Hematocrit Levels in Infant Heart Surgery

National Heart, Lung, and Blood Institute (NHLBI)

NCT00006183

COMPLETED 113 participants

Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System

University of Louisville

NCT03969836

COMPLETED Phase 2 110 participants

Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent

Marc Sakwa, MD

NCT01681095

COMPLETED NA 72 participants

Transseptal Needle Versus Radiofrequency Energy for Left Atrial Access

University of California, San Francisco

NCT01209260

COMPLETED NA 65 participants

D2-EPG Study: Evaluation of New Sensing Circuitry and Capture Management

Medtronic Cardiac Rhythm and Heart Failure

NCT00328705

COMPLETED 61 participants

Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers

National Institute on Aging (NIA)

NCT00233311

COMPLETED NA 52 participants

Exercise as a Modulator of Immune Risk Factors for Ischemic Heart Disease

East Tennessee State University

NCT04195932

COMPLETED 51 participants

SelectSecure 3830 Lead Imaging

Medtronic Cardiac Rhythm and Heart Failure

NCT03941275

COMPLETED NA 47 participants

Mindfulness & Stress Management Study for Cardiac Patients

University of Minnesota

NCT02722213

COMPLETED NA 37 participants

Dairy Fat and Fermentation Study

Tufts University

NCT05840081

COMPLETED NA 28 participants

Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors

Loma Linda University

NCT03429920

COMPLETED 25 participants

AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation

Ablacon

NCT05481359

COMPLETED Phase 4 21 participants

Pilot Study of Using Copeptin to Predict Response to Tolvaptan

University of North Carolina, Chapel Hill

NCT01346072

COMPLETED NA 9 participants

Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness

Katherine Vickery

NCT06025721

COMPLETED Phase 3 3 participants

Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia

National Heart, Lung, and Blood Institute (NHLBI)

NCT00099996

← Previous Page 2 of 2

Phase Distribution

PhaseTrial count
Phase 2 7
Phase 3 9
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Heart Diseases Trial Landscape

86 indexed Heart Diseases studies · 26 recruiting (30%).

Phase mix: 11 late (III/IV) vs 7 early (I/II).

Top sponsor: National Heart, Lung, and Blood Institute (NHLBI) (7 trials), 9 others listed. 36 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Heart Diseases?

PlainTrial tracks 86 US clinical trials for Heart Diseases, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Heart Diseases?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.