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Heart Diseases: later-stage trial registry
26 of 86 indexed Heart Diseases trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #160 of 28,707 conditions by registered trial count.
86 US clinical trials · 26 currently recruiting · #160 of 28,707 conditions by registered trial count
Heart Diseases: 86 US clinical trials tracked, 26 recruiting.
Heart Diseases is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 26 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is National Heart, Lung, and Blood Institute (NHLBI), running 7 of these trials.
Enrollment posture brief
Registry condition heart-diseases
OPEN 26 | RECR 30% | LATE 11 | EARLY 7 | RANK #160 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Smoking Cessation (30% recruiting · 189 trials)
Heart Diseases lists 26 open slots (30% of 86 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Heart Diseases on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Heart Diseases is recruiting below its size-band peers.
26 of 86 indexed trials (30.2%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Heart Diseases trials is spread across many organizations.
National Heart, Lung, and Blood Institute (NHLBI) accounts for 7 of 86 trials (8.1%). 64 distinct sponsors appear on at least one study for this condition label.
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Typical Heart Diseases enrolment sits around 349 participants.
Median target enrolment is 349 among the 86 trials that report a genuine target (sentinel values excluded). 16 of those (18.6%) plan for fewer than 100 participants.
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Heart Diseases splits between interventional and observational designs.
54 interventional and 32 observational studies make up this index (62.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
86 total, page 2 of 2
CV Disease in Adolescents With Type 2 Diabetes
Children's Hospital Medical Center, Cincinnati
NCT00114998
Heart Rate Variability and Sudden Cardiac Death
Columbia University
NCT00005235
Physician Uncertainty Reduction for Hypertension
Baylor College of Medicine
NCT00201084
Comparison of Two Methods to Diagnose Coronary Artery Disease
Johns Hopkins University
NCT00063531
Developing and Testing a Personalized Evidence-based Shared Decision-making Tool for Stent Selection
University of Missouri, Kansas City
NCT02046902
HUDDLE: Heart Health: Understanding & Diagnosing Disease by Leveraging Echocardiograms
Edwards Lifesciences
NCT05009589
Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal
Windber Research Institute
NCT01805492
Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery
Duke University
NCT00041392
Pain Assessment, Incidence & Nature in Heart Failure
PC-HEART
NCT00444301
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
University of Washington
NCT00880178
Multidisciplinary Study of Right Ventricular Dysplasia
University of Arizona
NCT00024505
Estrogen, HDL, and Coronary Heart Disease in Women
Tufts University
NCT00083824
Effects of Resistance and Aerobic Exercise on Cardiovascular Health
Duke University
NCT00275145
Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
Baylor Research Institute
NCT00224809
Virtual AppLication-supported ENvironment To INcrease Exercise During Cardiac Rehabilitation Study
University of Michigan
NCT04587882
Epidemiology of Hypertensive Emergency
Columbia University
NCT00005240
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001891
Effect of Targeted Interventions to Improve Value Based Health Care for Inpatient Cardiology Patients
Vanderbilt University Medical Center
NCT03173157
Sapphire 3 CTO Study
OrbusNeich
NCT06358508
Strong People Strength Training Study
Cornell University
NCT04203563
Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers
University of Miami
NCT00253682
Comparison of Hematocrit Levels in Infant Heart Surgery
National Heart, Lung, and Blood Institute (NHLBI)
NCT00006183
Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System
University of Louisville
NCT03969836
Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent
Marc Sakwa, MD
NCT01681095
Transseptal Needle Versus Radiofrequency Energy for Left Atrial Access
University of California, San Francisco
NCT01209260
D2-EPG Study: Evaluation of New Sensing Circuitry and Capture Management
Medtronic Cardiac Rhythm and Heart Failure
NCT00328705
Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers
National Institute on Aging (NIA)
NCT00233311
Exercise as a Modulator of Immune Risk Factors for Ischemic Heart Disease
East Tennessee State University
NCT04195932
SelectSecure 3830 Lead Imaging
Medtronic Cardiac Rhythm and Heart Failure
NCT03941275
Mindfulness & Stress Management Study for Cardiac Patients
University of Minnesota
NCT02722213
Dairy Fat and Fermentation Study
Tufts University
NCT05840081
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
Loma Linda University
NCT03429920
AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation
Ablacon
NCT05481359
Pilot Study of Using Copeptin to Predict Response to Tolvaptan
University of North Carolina, Chapel Hill
NCT01346072
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
Katherine Vickery
NCT06025721
Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia
National Heart, Lung, and Blood Institute (NHLBI)
NCT00099996
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 7 |
| Phase 3 | 9 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Heart Diseases records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Heart Diseases trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Heart Diseases page
86 registered trials, 26 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 26 Heart Diseases trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Heart, Lung, and Blood Institute (NHLBI) sponsors the most Heart Diseases trials on record, review their full trial history before evaluating a specific study. See National Heart, Lung, and Blood Institute (NHLBI)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Heart Diseases condition card totals 86 registered trials; most-linked intervention Medication; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.