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Heart Diseases clinical trials
26 of 86 indexed Heart Diseases trials are currently recruiting.
86 US clinical trials · 26 currently recruiting
Heart Diseases is the subject of 86 registered US clinical trials on ClinicalTrials.gov, 26 of them currently open to new participants. 11 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is National Heart, Lung, and Blood Institute (NHLBI), running 7 of these trials.
The research picture
Heart Diseases has 86 registered US clinical trials, 26 of them open to new participants right now, about 30% of the total.
- 26
- recruiting participants now
- 30%
- of trials open to enrollment
- 11
- in Phase 3–4 (later-stage)
- 7
- top sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Active & Recent Trials
86 total, page 2 of 2
CV Disease in Adolescents With Type 2 Diabetes
Children's Hospital Medical Center, Cincinnati
NCT00114998
Heart Rate Variability and Sudden Cardiac Death
Columbia University
NCT00005235
Physician Uncertainty Reduction for Hypertension
Baylor College of Medicine
NCT00201084
Comparison of Two Methods to Diagnose Coronary Artery Disease
Johns Hopkins University
NCT00063531
Developing and Testing a Personalized Evidence-based Shared Decision-making Tool for Stent Selection
University of Missouri, Kansas City
NCT02046902
HUDDLE: Heart Health: Understanding & Diagnosing Disease by Leveraging Echocardiograms
Edwards Lifesciences
NCT05009589
Global Profiling of Gene and Protein Expression Associated With Coronary Heart Disease Reversal
Windber Research Institute
NCT01805492
Effects of Magnesium on Individuals Undergoing Coronary Artery Bypass Graft Surgery
Duke University
NCT00041392
Pain Assessment, Incidence & Nature in Heart Failure
PC-HEART
NCT00444301
Plaque Inflammation and Dysfunctional HDL in AIM-HIGH
University of Washington
NCT00880178
Multidisciplinary Study of Right Ventricular Dysplasia
University of Arizona
NCT00024505
Estrogen, HDL, and Coronary Heart Disease in Women
Tufts University
NCT00083824
Effects of Resistance and Aerobic Exercise on Cardiovascular Health
Duke University
NCT00275145
Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation
Baylor Research Institute
NCT00224809
Virtual AppLication-supported ENvironment To INcrease Exercise During Cardiac Rehabilitation Study
University of Michigan
NCT04587882
Epidemiology of Hypertensive Emergency
Columbia University
NCT00005240
Myocardial Contrast Echocardiography (MCE) to Check for Living and Working Heart Muscle
National Heart, Lung, and Blood Institute (NHLBI)
NCT00001891
Effect of Targeted Interventions to Improve Value Based Health Care for Inpatient Cardiology Patients
Vanderbilt University Medical Center
NCT03173157
Sapphire 3 CTO Study
OrbusNeich
NCT06358508
Strong People Strength Training Study
Cornell University
NCT04203563
Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers
University of Miami
NCT00253682
Comparison of Hematocrit Levels in Infant Heart Surgery
National Heart, Lung, and Blood Institute (NHLBI)
NCT00006183
Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System
University of Louisville
NCT03969836
Custodiol-HTK (Histidine-tryptophan-ketoglutarate) Solution as a Cardioplegic Agent
Marc Sakwa, MD
NCT01681095
Transseptal Needle Versus Radiofrequency Energy for Left Atrial Access
University of California, San Francisco
NCT01209260
D2-EPG Study: Evaluation of New Sensing Circuitry and Capture Management
Medtronic Cardiac Rhythm and Heart Failure
NCT00328705
Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers
National Institute on Aging (NIA)
NCT00233311
Exercise as a Modulator of Immune Risk Factors for Ischemic Heart Disease
East Tennessee State University
NCT04195932
SelectSecure 3830 Lead Imaging
Medtronic Cardiac Rhythm and Heart Failure
NCT03941275
Mindfulness & Stress Management Study for Cardiac Patients
University of Minnesota
NCT02722213
Dairy Fat and Fermentation Study
Tufts University
NCT05840081
Effect of Fermented Soy Based Product on Cardiometabolic Risk Factors
Loma Linda University
NCT03429920
AF-FLOW Registry to Evaluate Electrographic Flow Mapping in Patients Undergoing Ablation for Atrial Fibrillation
Ablacon
NCT05481359
Pilot Study of Using Copeptin to Predict Response to Tolvaptan
University of North Carolina, Chapel Hill
NCT01346072
Behavior Change Intervention for Cardiovascular Risk Reduction Among People Experiencing Homelessness
Katherine Vickery
NCT06025721
Higher-Dose Ezetimibe to Treat Homozygous Sitosterolemia
National Heart, Lung, and Blood Institute (NHLBI)
NCT00099996
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 7 |
| Phase 3 | 9 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Heart Diseases Trial Landscape
86 indexed Heart Diseases studies · 26 recruiting (30%).
Phase mix: 11 late (III/IV) vs 7 early (I/II).
Top sponsor: National Heart, Lung, and Blood Institute (NHLBI) (7 trials), 9 others listed. 36 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Heart Diseases?
PlainTrial tracks 86 US clinical trials for Heart Diseases, of which 26 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Heart Diseases?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.