Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer
NCT00047008 · View on ClinicalTrials.gov ↗
Study Summary
RATIONALE: Radiation therapy (RT) uses high-energy x-rays to damage tumor cells. Giving radiation therapy in different ways and combining it with chemotherapy before surgery may kill more tumor cells. It is not yet known which radiation therapy regimen combined with chemotherapy with or without surgery is more effective for head and neck cancer. PURPOSE: Randomized phase III trial to compare two different radiation therapy regimens combined with cisplatin with or without surgery in treating patients who have stage III or stage IV head and neck cancer.
Conditions Studied
Interventions
- DRUG cisplatin
- RADIATION Standard fractionation RT
- RADIATION Accelerated fractionation radiation therapy
- PROCEDURE Conventional surgery for select patients
Study Locations (20)
California
- Providence Saint Joseph Medical Center - Burbank — Burbank
- Saint Rose Hospital — Hayward
- Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital — Inglewood
- Valley Memorial Hospital — Livermore
- Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles
- Providence Holy Cross Cancer Center — Mission Hills
- Highland General Hospital — Oakland
- CCOP - Bay Area Tumor Institute — Oakland
- Summit Medical Center — Oakland
- Pomona Valley Hospital Medical Center — Pomona
- Radiological Associates of Sacramento Medical Group, Inc. — Sacramento
- University of California Davis Cancer Center — Sacramento
- Naval Medical Center - San Diego — San Diego
Arizona
- Foundation for Cancer Research and Education — Phoenix
- CCOP - Mayo Clinic Scottsdale Oncology Program — Scottsdale
- Scottsdale Healthcare - Shea — Scottsdale
- Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn — Scottsdale
Alabama
- Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham
- Mobile Infirmary Medical Center — Mobile
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 743 participants |
| Start Date | 2002-07 |
| Est. Completion | 2022-05-20 |
| Phase | Phase 3 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00047008
The ClinicalTrials.gov registry entry for NCT00047008 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 743 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Radiation Therapy Oncology Group, which has 37 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Head and Neck Cancer appearing as the primary indexed condition, and to 4 interventions — of which cisplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00047008 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Arizona, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00047008 about?
NCT00047008 is a clinical study titled "Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer". RATIONALE: Radiation therapy (RT) uses high-energy x-rays to damage tumor cells. Giving radiation therapy in different ways and combining it with chemotherapy before surgery may kill more tumor cells. It is not yet known which radiation therapy regimen combined with chemotherapy with or without surg...
What is the current status of trial NCT00047008?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 743 participants. The study started on 2002-07. Estimated completion is 2022-05-20.
What conditions does trial NCT00047008 study?
This clinical trial studies the following conditions: Head and Neck Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00047008?
The interventions under investigation include: cisplatin (DRUG), Standard fractionation RT (RADIATION), Accelerated fractionation radiation therapy (RADIATION), Conventional surgery for select patients (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00047008?
This trial is sponsored by Radiation Therapy Oncology Group, which has 37 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00047008 being conducted?
This trial has 20 study locations across Alabama, Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.