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ACTIVE NOT RECRUITING Phase 1

INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)

NCT03491683 · View on ClinicalTrials.gov ↗

Study Summary

Phase 1/2 trial to evaluate safety, immunogenicity and preliminary efficacy of INO-5401 and INO-9012 in combination with cemiplimab (REGN2810), with radiation and chemotherapy, in subjects with newly-diagnosed glioblastoma (GBM).

Conditions Studied

Interventions

  • RADIATION Radiation Therapy
  • DRUG Temozolomide
  • BIOLOGICAL Cemiplimab
  • BIOLOGICAL INO-5401
  • BIOLOGICAL INO-9012

Study Locations (20)

New York

  • New York University Langone Medical Center; Perlmutter Cancer Center — New York
  • Icahn School of Medicine at Mount Sinai — New York
  • Columbia University Medical Center The Neurological Institute of New York — New York
  • New York-Presbyterian Hospital/Weill Cornell Medical Center — New York

California

  • City of Hope — Duarte
  • Stanford University, School of Medicine — Palo Alto
  • University of California, San Francisco — San Francisco

Florida

  • University of Miami - Sylvester Comprehensive Cancer Center — Miami
  • Moffitt Cancer Center — Tampa

Pennsylvania

  • University of Pennsylvania Health System: Penn Medicine — Philadelphia
  • UPMC Cancer Center Neuro-Oncology; UPMC Cancer Pavilion — Pittsburgh

Texas

  • Texas Oncology — Austin
  • Baylor College of Medicine — Houston

Georgia

  • Emory University School of Medicine — Atlanta

Massachusetts

  • Dana-Farber Cancer Institute — Boston

Michigan

  • Henry Ford Health System — Detroit

Trial Details

FieldValue
Enrollment Target 52 participants
Start Date 2018-05-31
Est. Completion 2026-12-31
Phase Phase 1

Sponsor

Inovio Pharmaceuticals

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03491683

The ClinicalTrials.gov registry entry for NCT03491683 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 52 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Inovio Pharmaceuticals, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Glioblastoma appearing as the primary indexed condition, and to 5 interventions — of which Radiation Therapy is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03491683 reports 20 study locations spanning 12 distinct geographic areas — top geographies include New York, California, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03491683 about?

NCT03491683 is a clinical study titled "INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)". Phase 1/2 trial to evaluate safety, immunogenicity and preliminary efficacy of INO-5401 and INO-9012 in combination with cemiplimab (REGN2810), with radiation and chemotherapy, in subjects with newly-diagnosed glioblastoma (GBM).

What is the current status of trial NCT03491683?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 52 participants. The study started on 2018-05-31. Estimated completion is 2026-12-31.

What conditions does trial NCT03491683 study?

This clinical trial studies the following conditions: Glioblastoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03491683?

The interventions under investigation include: Radiation Therapy (RADIATION), Temozolomide (DRUG), Cemiplimab (BIOLOGICAL), INO-5401 (BIOLOGICAL), INO-9012 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03491683?

This trial is sponsored by Inovio Pharmaceuticals, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03491683 being conducted?

This trial has 20 study locations across California, Florida, Georgia, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial