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Fatigue clinical trials
33 of 110 indexed Fatigue trials are currently recruiting.
110 US clinical trials · 33 currently recruiting
Fatigue is the subject of 110 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 8 of these trials.
The research picture
Fatigue has 110 registered US clinical trials, 33 of them open to new participants right now, about 30% of the total.
- 33
- recruiting participants now
- 30%
- of trials open to enrollment
- 9
- in Phase 3–4 (later-stage)
- 8
- top sponsor: M.D. Anderson Cancer Center
Active & Recent Trials
110 total, page 1 of 3
Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis
Accelerated Cure Project for Multiple Sclerosis
NCT06441617
Patient-Centered Assessment of Symptoms and Outcomes
National Center for Complementary and Integrative Health (NCCIH)
NCT03952624
Wellness App for Sleep Disturbance in Hematological Cancer Patients
The University of Texas Health Science Center at San Antonio
NCT05294991
The Fit With Us Study
University of Alabama at Birmingham
NCT06207084
Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers
M.D. Anderson Cancer Center
NCT06085716
Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency
Seattle Institute for Biomedical and Clinical Research
NCT04301765
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
Hugo W. Moser Research Institute at Kennedy Krieger
NCT07278388
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
M.D. Anderson Cancer Center
NCT05474846
Behavioral and Neural Representations of Subjective Effort Cost
Hugo W. Moser Research Institute at Kennedy Krieger
NCT04041154
Active Living After Cancer: Implementation Within Be Well Acres Homes
M.D. Anderson Cancer Center
NCT06907706
Neural and Cognitive Consequences of COVID-19 Survival
San Francisco Veterans Affairs Medical Center
NCT06208943
Training in Evidence-based Treatments in Psycho-Oncology
Massachusetts General Hospital
NCT05674357
Increasing Physical Activity for Adults With Multiple Sclerosis (MS)
University of Washington
NCT06270641
Virtual Patient Groups for Sarcoidosis Associated Fatigue
The Cleveland Clinic
NCT07073963
Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue
University of Maryland, Baltimore
NCT06482515
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
University of California, Davis
NCT04984226
Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors
Wake Forest University Health Sciences
NCT06634381
CF Wellness Program
Johns Hopkins University
NCT07071324
Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention
M.D. Anderson Cancer Center
NCT07186556
Fatigue and Cognitive Demand With Aging
University of Oklahoma
NCT05121272
Lifting More Than Weights: Resistance Exercise Program Across Socioeconomic Groups for Cancer-Related Fatigue Management
West Virginia University
NCT06960720
Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors
Wake Forest University Health Sciences
NCT06819254
Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
University of Maryland, Baltimore
NCT05977179
A Trial of Dyanavel XR in Treating Co-occurring Fatigue Symptoms in Adults With Attention Deficit Hyperactivity Disorder (ADHD).
Rochester Center for Behavioral Medicine
NCT06248229
Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus
ChromaDex
NCT07251608
Neuromodulation and Fatigue
University of Oklahoma
NCT05487131
Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer
University of Rochester
NCT06295588
Behavioral and Neural Correlates of Post-Stroke Fatigue
Texas Woman's University
NCT06088914
Eccentric Exercise and Fatigue in Multiple Sclerosis
Hunter College of City University of New York
NCT06505421
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
University of Illinois at Chicago
NCT05094297
Exercise to ReGain Stamina and Energy (The EXERGISE Study)
University of Florida
NCT05684367
Artemis Sleep Countermeasures
National Aeronautics and Space Administration (NASA)
NCT06531733
Transcranial Direct Current Stimulation for Post-stroke Fatigue
Weill Medical College of Cornell University
NCT05816603
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
Canadian Cancer Trials Group
NCT00819208
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
M.D. Anderson Cancer Center
NCT02194387
Lupus Intervention for Fatigue Trial
Northwestern University
NCT02653287
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors
University of Alabama at Birmingham
NCT04088708
High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV
University of Colorado, Denver
NCT04550676
Physical Activity and Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Advanced Cancer
M.D. Anderson Cancer Center
NCT02491632
Time-Restricted Eating to Address Persistent Cancer-Related Fatigue
University of Maryland, Baltimore
NCT05256888
MitoQ for Fatigue in Multiple Sclerosis (MS)
VA Office of Research and Development
NCT04267926
A Clinical Trial to Evaluate the Effects of a Herbal Tincture on Energy Levels, Weight Management, and Markers of Metabolic Health
Apothekary
NCT06949540
REACH (Restore Energy, Activity Can Help) Lupus Study
Tufts Medical Center
NCT06479213
Virtual Exercise Program to Reduce Cancer Related Fatigue
University of Colorado, Denver
NCT04533165
A Pilot rTMS Trial for Neuropsychiatric Symptoms of Long-COVID
University of California, Los Angeles
NCT06586398
Radicle Energy 24: A Study of Health and Wellness Products on Fatigue and Related Health Outcomes
Radicle Science
NCT06201689
Safety and Feasibility of Polychromatic Light Emitting Diode for Peripheral Catheter Illumination During Peripheral Intravenous Delivery of Normal Saline
UVLrx Therapeutics
NCT02785133
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
Wake Forest University Health Sciences
NCT01407770
Radicle Energy™ 24_RCA: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes
Radicle Science
NCT07166523
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 12 |
| Phase 3 | 7 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Fatigue Trial Landscape
110 indexed Fatigue studies · 33 recruiting (30%).
Phase mix: 9 late (III/IV) vs 21 early (I/II).
Top sponsor: M.D. Anderson Cancer Center (8 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Fatigue?
PlainTrial tracks 110 US clinical trials for Fatigue, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Fatigue?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.