Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 33 recruiting now official registry

Fatigue clinical trials

33 of 110 indexed Fatigue trials are currently recruiting.

110 US clinical trials · 33 currently recruiting

Fatigue is the subject of 110 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 8 of these trials.

The research picture

Fatigue has 110 registered US clinical trials, 33 of them open to new participants right now, about 30% of the total.

33
recruiting participants now
30%
of trials open to enrollment
9
in Phase 3–4 (later-stage)
8
top sponsor: M.D. Anderson Cancer Center
Phase 19Phase 212Phase 37Phase 42

Active & Recent Trials

110 total, page 1 of 3

RECRUITING NA 2,000 participants

Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis

Accelerated Cure Project for Multiple Sclerosis

NCT06441617

RECRUITING 692 participants

Patient-Centered Assessment of Symptoms and Outcomes

National Center for Complementary and Integrative Health (NCCIH)

NCT03952624

RECRUITING NA 276 participants

Wellness App for Sleep Disturbance in Hematological Cancer Patients

The University of Texas Health Science Center at San Antonio

NCT05294991

RECRUITING NA 257 participants

The Fit With Us Study

University of Alabama at Birmingham

NCT06207084

RECRUITING Phase 2 240 participants

Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers

M.D. Anderson Cancer Center

NCT06085716

RECRUITING Phase 2 230 participants

Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency

Seattle Institute for Biomedical and Clinical Research

NCT04301765

RECRUITING NA 200 participants

Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2

Hugo W. Moser Research Institute at Kennedy Krieger

NCT07278388

RECRUITING Phase 2 188 participants

Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer

M.D. Anderson Cancer Center

NCT05474846

RECRUITING NA 185 participants

Behavioral and Neural Representations of Subjective Effort Cost

Hugo W. Moser Research Institute at Kennedy Krieger

NCT04041154

RECRUITING NA 164 participants

Active Living After Cancer: Implementation Within Be Well Acres Homes

M.D. Anderson Cancer Center

NCT06907706

RECRUITING 150 participants

Neural and Cognitive Consequences of COVID-19 Survival

San Francisco Veterans Affairs Medical Center

NCT06208943

RECRUITING NA 115 participants

Training in Evidence-based Treatments in Psycho-Oncology

Massachusetts General Hospital

NCT05674357

RECRUITING NA 106 participants

Increasing Physical Activity for Adults With Multiple Sclerosis (MS)

University of Washington

NCT06270641

RECRUITING NA 100 participants

Virtual Patient Groups for Sarcoidosis Associated Fatigue

The Cleveland Clinic

NCT07073963

RECRUITING Phase 2 96 participants

Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue

University of Maryland, Baltimore

NCT06482515

RECRUITING Phase 2 80 participants

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD

University of California, Davis

NCT04984226

RECRUITING 80 participants

Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors

Wake Forest University Health Sciences

NCT06634381

RECRUITING NA 80 participants

CF Wellness Program

Johns Hopkins University

NCT07071324

RECRUITING NA 75 participants

Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention

M.D. Anderson Cancer Center

NCT07186556

RECRUITING NA 60 participants

Fatigue and Cognitive Demand With Aging

University of Oklahoma

NCT05121272

RECRUITING NA 60 participants

Lifting More Than Weights: Resistance Exercise Program Across Socioeconomic Groups for Cancer-Related Fatigue Management

West Virginia University

NCT06960720

RECRUITING Phase 4 60 participants

Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

Wake Forest University Health Sciences

NCT06819254

RECRUITING NA 56 participants

Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome

University of Maryland, Baltimore

NCT05977179

RECRUITING Phase 4 50 participants

A Trial of Dyanavel XR in Treating Co-occurring Fatigue Symptoms in Adults With Attention Deficit Hyperactivity Disorder (ADHD).

Rochester Center for Behavioral Medicine

NCT06248229

RECRUITING Phase 1 40 participants

Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus

ChromaDex

NCT07251608

RECRUITING NA 40 participants

Neuromodulation and Fatigue

University of Oklahoma

NCT05487131

RECRUITING Phase 2 40 participants

Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer

University of Rochester

NCT06295588

RECRUITING NA 32 participants

Behavioral and Neural Correlates of Post-Stroke Fatigue

Texas Woman's University

NCT06088914

RECRUITING 30 participants

Eccentric Exercise and Fatigue in Multiple Sclerosis

Hunter College of City University of New York

NCT06505421

RECRUITING NA 25 participants

Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

University of Illinois at Chicago

NCT05094297

RECRUITING NA 24 participants

Exercise to ReGain Stamina and Energy (The EXERGISE Study)

University of Florida

NCT05684367

RECRUITING NA 24 participants

Artemis Sleep Countermeasures

National Aeronautics and Space Administration (NASA)

NCT06531733

RECRUITING Phase 2 24 participants

Transcranial Direct Current Stimulation for Post-stroke Fatigue

Weill Medical College of Cornell University

NCT05816603

ACTIVE NOT RECRUITING NA 889 participants

Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer

Canadian Cancer Trials Group

NCT00819208

ACTIVE NOT RECRUITING NA 456 participants

A Trial of a Positive Psychology Intervention for Older Adults (RESET)

University of Michigan

NCT05451589

ACTIVE NOT RECRUITING NA 337 participants

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

M.D. Anderson Cancer Center

NCT02194387

ACTIVE NOT RECRUITING NA 200 participants

Lupus Intervention for Fatigue Trial

Northwestern University

NCT02653287

ACTIVE NOT RECRUITING NA 126 participants

Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors

University of Alabama at Birmingham

NCT04088708

ACTIVE NOT RECRUITING NA 118 participants

High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV

University of Colorado, Denver

NCT04550676

ACTIVE NOT RECRUITING Phase 2 90 participants

Physical Activity and Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Advanced Cancer

M.D. Anderson Cancer Center

NCT02491632

ACTIVE NOT RECRUITING NA 50 participants

Time-Restricted Eating to Address Persistent Cancer-Related Fatigue

University of Maryland, Baltimore

NCT05256888

ACTIVE NOT RECRUITING Phase 1 45 participants

MitoQ for Fatigue in Multiple Sclerosis (MS)

VA Office of Research and Development

NCT04267926

ACTIVE NOT RECRUITING NA 40 participants

A Clinical Trial to Evaluate the Effects of a Herbal Tincture on Energy Levels, Weight Management, and Markers of Metabolic Health

Apothekary

NCT06949540

ACTIVE NOT RECRUITING NA 36 participants

REACH (Restore Energy, Activity Can Help) Lupus Study

Tufts Medical Center

NCT06479213

ACTIVE NOT RECRUITING NA 19 participants

Virtual Exercise Program to Reduce Cancer Related Fatigue

University of Colorado, Denver

NCT04533165

ACTIVE NOT RECRUITING NA 10 participants

A Pilot rTMS Trial for Neuropsychiatric Symptoms of Long-COVID

University of California, Los Angeles

NCT06586398

COMPLETED NA 5,543 participants

Radicle Energy 24: A Study of Health and Wellness Products on Fatigue and Related Health Outcomes

Radicle Science

NCT06201689

COMPLETED NA 3,063 participants

Safety and Feasibility of Polychromatic Light Emitting Diode for Peripheral Catheter Illumination During Peripheral Intravenous Delivery of Normal Saline

UVLrx Therapeutics

NCT02785133

COMPLETED 1,000 participants

Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer

Wake Forest University Health Sciences

NCT01407770

COMPLETED NA 501 participants

Radicle Energy™ 24_RCA: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes

Radicle Science

NCT07166523

Page 1 of 3 Next →

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 12
Phase 3 7
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Fatigue Trial Landscape

110 indexed Fatigue studies · 33 recruiting (30%).

Phase mix: 9 late (III/IV) vs 21 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Fatigue?

PlainTrial tracks 110 US clinical trials for Fatigue, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Fatigue?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.