Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Fatigue: early-phase trial registry
33 of 110 indexed Fatigue trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #116 of 28,707 conditions by registered trial count.
110 US clinical trials · 33 currently recruiting · #116 of 28,707 conditions by registered trial count
Fatigue: 110 US clinical trials tracked, 33 recruiting.
Fatigue is the subject of 110 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 8 of these trials.
Enrollment posture brief
Registry condition fatigue
OPEN 33 | RECR 30% | LATE 9 | EARLY 21 | RANK #116 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Adrenocortical Carcinoma (30% recruiting · 10 trials)
Fatigue lists 33 open slots (30% of 110 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Fatigue on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Fatigue is recruiting below its size-band peers.
33 of 110 indexed trials (30%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Fatigue trials is spread across many organizations.
M.D. Anderson Cancer Center accounts for 8 of 110 trials (7.3%). 74 distinct sponsors appear on at least one study for this condition label.
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Most Fatigue trials plan to enrol fewer than 100 people.
Median target enrolment is 64 among the 110 trials that report a genuine target (sentinel values excluded). 70 of those (63.6%) plan for fewer than 100 participants.
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Fatigue research is mostly interventional.
102 interventional and 8 observational studies make up this index (92.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
110 total, page 1 of 3
Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis
Accelerated Cure Project for Multiple Sclerosis
NCT06441617
Patient-Centered Assessment of Symptoms and Outcomes
National Center for Complementary and Integrative Health (NCCIH)
NCT03952624
Wellness App for Sleep Disturbance in Hematological Cancer Patients
The University of Texas Health Science Center at San Antonio
NCT05294991
The Fit With Us Study
University of Alabama at Birmingham
NCT06207084
Combination Therapy for Cancer Related Fatigue in Patients With Metastatic Cancers
M.D. Anderson Cancer Center
NCT06085716
Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency
Seattle Institute for Biomedical and Clinical Research
NCT04301765
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
Hugo W. Moser Research Institute at Kennedy Krieger
NCT07278388
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
M.D. Anderson Cancer Center
NCT05474846
Behavioral and Neural Representations of Subjective Effort Cost
Hugo W. Moser Research Institute at Kennedy Krieger
NCT04041154
Active Living After Cancer: Implementation Within Be Well Acres Homes
M.D. Anderson Cancer Center
NCT06907706
Neural and Cognitive Consequences of COVID-19 Survival
San Francisco Veterans Affairs Medical Center
NCT06208943
Training in Evidence-based Treatments in Psycho-Oncology
Massachusetts General Hospital
NCT05674357
Increasing Physical Activity for Adults With Multiple Sclerosis (MS)
University of Washington
NCT06270641
Virtual Patient Groups for Sarcoidosis Associated Fatigue
The Cleveland Clinic
NCT07073963
Take the Reins: The Effects of Nutrient Timing on Cancer-related Fatigue
University of Maryland, Baltimore
NCT06482515
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
University of California, Davis
NCT04984226
Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors
Wake Forest University Health Sciences
NCT06634381
CF Wellness Program
Johns Hopkins University
NCT07071324
Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention
M.D. Anderson Cancer Center
NCT07186556
Fatigue and Cognitive Demand With Aging
University of Oklahoma
NCT05121272
Lifting More Than Weights: Resistance Exercise Program Across Socioeconomic Groups for Cancer-Related Fatigue Management
West Virginia University
NCT06960720
Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors
Wake Forest University Health Sciences
NCT06819254
Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome
University of Maryland, Baltimore
NCT05977179
A Trial of Dyanavel XR in Treating Co-occurring Fatigue Symptoms in Adults With Attention Deficit Hyperactivity Disorder (ADHD).
Rochester Center for Behavioral Medicine
NCT06248229
Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus
ChromaDex
NCT07251608
Neuromodulation and Fatigue
University of Oklahoma
NCT05487131
Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer
University of Rochester
NCT06295588
Behavioral and Neural Correlates of Post-Stroke Fatigue
Texas Woman's University
NCT06088914
Eccentric Exercise and Fatigue in Multiple Sclerosis
Hunter College of City University of New York
NCT06505421
Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans
University of Illinois at Chicago
NCT05094297
Exercise to ReGain Stamina and Energy (The EXERGISE Study)
University of Florida
NCT05684367
Artemis Sleep Countermeasures
National Aeronautics and Space Administration (NASA)
NCT06531733
Transcranial Direct Current Stimulation for Post-stroke Fatigue
Weill Medical College of Cornell University
NCT05816603
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
Canadian Cancer Trials Group
NCT00819208
A Trial of a Positive Psychology Intervention for Older Adults (RESET)
University of Michigan
NCT05451589
Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members
M.D. Anderson Cancer Center
NCT02194387
Lupus Intervention for Fatigue Trial
Northwestern University
NCT02653287
Gut Microbe Composition, Exercise, and Breast Breast Cancer Survivors
University of Alabama at Birmingham
NCT04088708
High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV
University of Colorado, Denver
NCT04550676
Physical Activity and Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Advanced Cancer
M.D. Anderson Cancer Center
NCT02491632
Time-Restricted Eating to Address Persistent Cancer-Related Fatigue
University of Maryland, Baltimore
NCT05256888
MitoQ for Fatigue in Multiple Sclerosis (MS)
VA Office of Research and Development
NCT04267926
A Clinical Trial to Evaluate the Effects of a Herbal Tincture on Energy Levels, Weight Management, and Markers of Metabolic Health
Apothekary
NCT06949540
REACH (Restore Energy, Activity Can Help) Lupus Study
Tufts Medical Center
NCT06479213
Virtual Exercise Program to Reduce Cancer Related Fatigue
University of Colorado, Denver
NCT04533165
A Pilot rTMS Trial for Neuropsychiatric Symptoms of Long-COVID
University of California, Los Angeles
NCT06586398
Radicle Energy 24: A Study of Health and Wellness Products on Fatigue and Related Health Outcomes
Radicle Science
NCT06201689
Safety and Feasibility of Polychromatic Light Emitting Diode for Peripheral Catheter Illumination During Peripheral Intravenous Delivery of Normal Saline
UVLrx Therapeutics
NCT02785133
Genetic Susceptibility to Radiation-Induced Skin Reactions in Racial/Ethnic Groups of Patients With Breast Cancer
Wake Forest University Health Sciences
NCT01407770
Radicle Energy™ 24_RCA: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes
Radicle Science
NCT07166523
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 12 |
| Phase 3 | 7 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Fatigue records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Fatigue trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Fatigue page
110 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Fatigue trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Fatigue trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Fatigue condition card totals 110 registered trials; most-linked intervention questionnaire administration; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.