Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Fatigue clinical trials
33 of 110 indexed Fatigue trials are currently recruiting.
110 US clinical trials · 33 currently recruiting
Fatigue is the subject of 110 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 8 of these trials.
The research picture
Fatigue has 110 registered US clinical trials, 33 of them open to new participants right now, about 30% of the total.
- 33
- recruiting participants now
- 30%
- of trials open to enrollment
- 9
- in Phase 3–4 (later-stage)
- 8
- top sponsor: M.D. Anderson Cancer Center
Active & Recent Trials
110 total, page 2 of 3
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
Radicle Science
NCT06749288
Yoga in Treating Sleep Disturbance in Cancer Survivors
Gary Morrow
NCT00397930
Levocarnitine in Treating Fatigue in Cancer Patients
ECOG-ACRIN Cancer Research Group
NCT00091169
Evaluation and Diagnosis of People With Pain and Fatigue Syndromes
National Institute of Nursing Research (NINR)
NCT00677157
Epoetin Alfa With or Without Dexamethasone in Treating Fatigue and Anemia in Patients With Hormone-Refractory Prostate Cancer
Eastern Cooperative Oncology Group
NCT00060398
(Valerian) for Improving Sleep in Patients With Cancer Receiving Adjuvant Therapy
Alliance for Clinical Trials in Oncology
NCT00075842
Light Therapy for PD - Dose Selection
Massachusetts General Hospital
NCT04291014
Insomnia Self-Management in Heart Failure
Yale University
NCT02660385
Systematic Light Exposure for Fatigue in Breast Cancer Patients
Icahn School of Medicine at Mount Sinai
NCT03217201
A Brief Patient-Controlled Intervention for a Symptom Cluster in Advanced Cancer
University of Wisconsin, Madison
NCT01954420
Acupressure for Fatigue in Ovarian Cancer Survivors
University of Michigan Rogel Cancer Center
NCT03763838
Strong People Strength Training Study
Cornell University
NCT04203563
Methylphenidate in Treating Patients With Fatigue Caused by Cancer
Alliance for Clinical Trials in Oncology
NCT00376675
Nurse-Provided Care or Standard Care in Treating Patients With Pancreatic Cancer
City of Hope Medical Center
NCT00902733
Patient Controlled Methylphenidate for Cancer Related Fatigue: A Double Blind, Randomized, Placebo Controlled Trial
M.D. Anderson Cancer Center
NCT05041946
Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant
Northside Hospital
NCT01084694
Gulf War Illness Inflammation Reduction Trial
Minneapolis Veterans Affairs Medical Center
NCT02506192
Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
University of California, San Francisco
NCT00755313
Evaluate the Effectiveness and Safety of the Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health
Supplement Formulators
NCT05170113
The "PC-LIGHT" Study
Northwestern University
NCT03419585
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
The University of Texas Medical Branch, Galveston
NCT03554265
Management of Insomnia in Breast Cancer Patients
Stanford University
NCT01011218
Stepped-Care Telehealth for Distress in Cancer Survivors
Wake Forest University Health Sciences
NCT03060096
Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With Unresectable Non-Small Cell Lung Cancer (Infliximab Treatment Discontinued Effective 10/05/05)
Alliance for Clinical Trials in Oncology
NCT00040885
Muscadine Grape Extract to Improve Fatigue
Wake Forest University Health Sciences
NCT04495751
Light Therapy to Increase Energy in Adolescents and Young Adults Newly Diagnosed With Solid Tumors: A Pilot Study
St. Jude Children's Research Hospital
NCT02429063
Treating Cancer-Related Fatigue Through Systematic Light Exposure
Icahn School of Medicine at Mount Sinai
NCT01873794
Acupuncture to Treat Cancer-Related Fatigue in Breast Cancer Patients
University of Pittsburgh
NCT00177840
S1008: Exercise, Diet, & Counseling in Improving Weight Loss in Overweight Female Breast or Colorectal Cancer Survivors
SWOG Cancer Research Network
NCT01453452
Initial Assessment of an Internet-based Symptom Management Intervention in Early Stage Breast Cancer
University of Michigan
NCT02495155
The Effect of Walking on Fatigue After Chemotherapy in Patients 65 and Older
UNC Lineberger Comprehensive Cancer Center
NCT02191982
Healing Touch in Treating Fatigue in Women Undergoing Radiation Therapy for Breast Cancer
Vanderbilt-Ingram Cancer Center
NCT00574145
The Effect of Aroma on Fatigue Scores Among Women With Hypothyroidism
Nutraceuticals Research Institute
NCT03465176
The Effect of Oral D-Ribose in "Baby Boomers" With Fatigue. A Randomized, Double-Blind Study
Bioenergy Life Science
NCT00821067
MS Symptom Management Study
University of Washington
NCT02474940
Effectiveness of 10-minute Chair Massage Versus 10-minute Break to Reduce Stress and Improve Well-being
Geisinger Clinic
NCT04787107
Effect of Beta-Alanine on Heart Rate Response
University of North Carolina, Chapel Hill
NCT01745016
Support for Caregivers of Older Adults With Cognitive Decline
State University of New York at Buffalo
NCT04787068
Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors
Ohio State University Comprehensive Cancer Center
NCT01929720
KAM: Kids Are Moving
University of Minnesota
NCT02626637
Patient Controlled Administration of Methylphenidate for Cancer Related Fatigue - PRN Methylphenidate
M.D. Anderson Cancer Center
NCT02361125
CBSM Intervention Via mHealth to Ameliorate HIV-related Fatigue
Medical University of South Carolina
NCT03149094
Art and Surface Electromyography (EMG)
Logan College of Chiropractic
NCT00731991
Phase II Early Behavioral Intervention in BMT w/ Sleep Disturbance-Assess QOL+Fatigue+Cognitive f(x)
Stanford University
NCT01536977
Alterations in Gait, Strength, and Power After Ruck Marching
State University of New York at Buffalo
NCT05309603
Effects of Muscle Fatigue and Kinesio Taping on Shoulder Position Sense
University of Oregon
NCT02104570
Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
Alliance for Clinical Trials in Oncology
NCT00005850
Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia
Pfizer
NCT04803305
Vagal Nerve Stimulation for Post COVID Fatigue
Mayo Clinic
NCT05445427
Virtual Reality Meditation for Fatigue
University of Washington
NCT04804462
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 12 |
| Phase 3 | 7 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Fatigue Trial Landscape
110 indexed Fatigue studies · 33 recruiting (30%).
Phase mix: 9 late (III/IV) vs 21 early (I/II).
Top sponsor: M.D. Anderson Cancer Center (8 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Fatigue?
PlainTrial tracks 110 US clinical trials for Fatigue, of which 33 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Fatigue?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.