Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Fatigue: early-phase trial registry
33 of 110 indexed Fatigue trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #116 of 28,707 conditions by registered trial count.
110 US clinical trials · 33 currently recruiting · #116 of 28,707 conditions by registered trial count
Fatigue: 110 US clinical trials tracked, 33 recruiting.
Fatigue is the subject of 110 registered US clinical trials on ClinicalTrials.gov, 33 of them currently open to new participants. 9 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 8 of these trials.
Enrollment posture brief
Registry condition fatigue
OPEN 33 | RECR 30% | LATE 9 | EARLY 21 | RANK #116 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Adrenocortical Carcinoma (30% recruiting · 10 trials)
Fatigue lists 33 open slots (30% of 110 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Fatigue on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Fatigue is recruiting below its size-band peers.
33 of 110 indexed trials (30%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Fatigue trials is spread across many organizations.
M.D. Anderson Cancer Center accounts for 8 of 110 trials (7.3%). 74 distinct sponsors appear on at least one study for this condition label.
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Most Fatigue trials plan to enrol fewer than 100 people.
Median target enrolment is 64 among the 110 trials that report a genuine target (sentinel values excluded). 70 of those (63.6%) plan for fewer than 100 participants.
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Fatigue research is mostly interventional.
102 interventional and 8 observational studies make up this index (92.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
110 total, page 2 of 3
Radicle Revive 24: A Study of Health and Wellness Products on Menopausal Health and Related Health Outcomes
Radicle Science
NCT06749288
Yoga in Treating Sleep Disturbance in Cancer Survivors
Gary Morrow
NCT00397930
Levocarnitine in Treating Fatigue in Cancer Patients
ECOG-ACRIN Cancer Research Group
NCT00091169
Evaluation and Diagnosis of People With Pain and Fatigue Syndromes
National Institute of Nursing Research (NINR)
NCT00677157
Epoetin Alfa With or Without Dexamethasone in Treating Fatigue and Anemia in Patients With Hormone-Refractory Prostate Cancer
Eastern Cooperative Oncology Group
NCT00060398
(Valerian) for Improving Sleep in Patients With Cancer Receiving Adjuvant Therapy
Alliance for Clinical Trials in Oncology
NCT00075842
Light Therapy for PD - Dose Selection
Massachusetts General Hospital
NCT04291014
Insomnia Self-Management in Heart Failure
Yale University
NCT02660385
Systematic Light Exposure for Fatigue in Breast Cancer Patients
Icahn School of Medicine at Mount Sinai
NCT03217201
A Brief Patient-Controlled Intervention for a Symptom Cluster in Advanced Cancer
University of Wisconsin, Madison
NCT01954420
Acupressure for Fatigue in Ovarian Cancer Survivors
University of Michigan Rogel Cancer Center
NCT03763838
Strong People Strength Training Study
Cornell University
NCT04203563
Methylphenidate in Treating Patients With Fatigue Caused by Cancer
Alliance for Clinical Trials in Oncology
NCT00376675
Nurse-Provided Care or Standard Care in Treating Patients With Pancreatic Cancer
City of Hope Medical Center
NCT00902733
Patient Controlled Methylphenidate for Cancer Related Fatigue: A Double Blind, Randomized, Placebo Controlled Trial
M.D. Anderson Cancer Center
NCT05041946
Caregiver Burden and Distress in Hematopoeitic Stem Cell Transplant
Northside Hospital
NCT01084694
Gulf War Illness Inflammation Reduction Trial
Minneapolis Veterans Affairs Medical Center
NCT02506192
Effects of Chemotherapy on the Brain in Women With Newly Diagnosed Early-Stage Breast Cancer
University of California, San Francisco
NCT00755313
Evaluate the Effectiveness and Safety of the Alpinia Galanga Formulation, Theacrine Formulation, and Caffeine Formulation on Fatigue, Mental Acuity, and Cognitive Health
Supplement Formulators
NCT05170113
The "PC-LIGHT" Study
Northwestern University
NCT03419585
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
The University of Texas Medical Branch, Galveston
NCT03554265
Management of Insomnia in Breast Cancer Patients
Stanford University
NCT01011218
Stepped-Care Telehealth for Distress in Cancer Survivors
Wake Forest University Health Sciences
NCT03060096
Docetaxel With or Without Infliximab in Treating Weight Loss, Loss of Appetite, and Fatigue in Patients With Unresectable Non-Small Cell Lung Cancer (Infliximab Treatment Discontinued Effective 10/05/05)
Alliance for Clinical Trials in Oncology
NCT00040885
Muscadine Grape Extract to Improve Fatigue
Wake Forest University Health Sciences
NCT04495751
Light Therapy to Increase Energy in Adolescents and Young Adults Newly Diagnosed With Solid Tumors: A Pilot Study
St. Jude Children's Research Hospital
NCT02429063
Treating Cancer-Related Fatigue Through Systematic Light Exposure
Icahn School of Medicine at Mount Sinai
NCT01873794
Acupuncture to Treat Cancer-Related Fatigue in Breast Cancer Patients
University of Pittsburgh
NCT00177840
S1008: Exercise, Diet, & Counseling in Improving Weight Loss in Overweight Female Breast or Colorectal Cancer Survivors
SWOG Cancer Research Network
NCT01453452
Initial Assessment of an Internet-based Symptom Management Intervention in Early Stage Breast Cancer
University of Michigan
NCT02495155
The Effect of Walking on Fatigue After Chemotherapy in Patients 65 and Older
UNC Lineberger Comprehensive Cancer Center
NCT02191982
Healing Touch in Treating Fatigue in Women Undergoing Radiation Therapy for Breast Cancer
Vanderbilt-Ingram Cancer Center
NCT00574145
The Effect of Aroma on Fatigue Scores Among Women With Hypothyroidism
Nutraceuticals Research Institute
NCT03465176
The Effect of Oral D-Ribose in "Baby Boomers" With Fatigue. A Randomized, Double-Blind Study
Bioenergy Life Science
NCT00821067
MS Symptom Management Study
University of Washington
NCT02474940
Effectiveness of 10-minute Chair Massage Versus 10-minute Break to Reduce Stress and Improve Well-being
Geisinger Clinic
NCT04787107
Effect of Beta-Alanine on Heart Rate Response
University of North Carolina, Chapel Hill
NCT01745016
Support for Caregivers of Older Adults With Cognitive Decline
State University of New York at Buffalo
NCT04787068
Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors
Ohio State University Comprehensive Cancer Center
NCT01929720
KAM: Kids Are Moving
University of Minnesota
NCT02626637
Patient Controlled Administration of Methylphenidate for Cancer Related Fatigue - PRN Methylphenidate
M.D. Anderson Cancer Center
NCT02361125
CBSM Intervention Via mHealth to Ameliorate HIV-related Fatigue
Medical University of South Carolina
NCT03149094
Art and Surface Electromyography (EMG)
Logan College of Chiropractic
NCT00731991
Phase II Early Behavioral Intervention in BMT w/ Sleep Disturbance-Assess QOL+Fatigue+Cognitive f(x)
Stanford University
NCT01536977
Alterations in Gait, Strength, and Power After Ruck Marching
State University of New York at Buffalo
NCT05309603
Effects of Muscle Fatigue and Kinesio Taping on Shoulder Position Sense
University of Oregon
NCT02104570
Combination Chemotherapy Plus Fluoxetine in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer
Alliance for Clinical Trials in Oncology
NCT00005850
Study to Compare the Effects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia
Pfizer
NCT04803305
Vagal Nerve Stimulation for Post COVID Fatigue
Mayo Clinic
NCT05445427
Virtual Reality Meditation for Fatigue
University of Washington
NCT04804462
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 12 |
| Phase 3 | 7 |
| Phase 4 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Fatigue records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Fatigue trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Fatigue page
110 registered trials, 33 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 33 Fatigue trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- M.D. Anderson Cancer Center sponsors the most Fatigue trials on record, review their full trial history before evaluating a specific study. See M.D. Anderson Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Fatigue condition card totals 110 registered trials; most-linked intervention questionnaire administration; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.