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RECRUITING Phase 1

A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

NCT04486352 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune checkpoint therapy with atezolizumab in participant with recurrent and/or persistent endometrial cancer. The main protocol provides a platform for genomic screening with homogeneous basic eligibility criteria in order to direct study participants into biomarker-matched study cohorts consisting of testing targeted agents.

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG Ipatasertib
  • DRUG Talazoparib
  • DRUG Atezolizumab - 28 Day Cycle
  • DRUG Trastuzumab emtansine

Study Locations (20)

California

  • City of Hope Comprehensive Cancer Center — Duarte
  • UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco

New Jersey

  • Englewood Health — Englewood
  • Atlantic Health Systems/Morristown Medical Center — Morristown

New York

  • Roswell Park — Buffalo
  • Weill Cornell Medicine — New York

District of Columbia

  • Medstar Georgetown Cancer Institute — Washington D.C.

Florida

  • Mount Sinai Comprehensive Cancer Center — Miami Beach

Illinois

  • University of Chicago — Chicago

Kansas

  • University of Kansas Cancer Center — Westwood

Maine

  • Maine Medical Center — Scarborough

Trial Details

FieldValue
Enrollment Target 148 participants
Start Date 2021-10-20
Est. Completion 2027-10
Phase Phase 1

Sponsor

Alliance Foundation Trials

71 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04486352

The ClinicalTrials.gov registry entry for NCT04486352 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 148 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance Foundation Trials, which has 71 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Endometrial Cancer appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04486352 reports 20 study locations spanning 17 distinct geographic areas — top geographies include California, New Jersey, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04486352 about?

NCT04486352 is a clinical study titled "A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer". This is a Phase IB/II multi-cohort study designed to evaluate the efficacy and safety of targeted agents with or without cancer immune checkpoint therapy with atezolizumab in participant with recurrent and/or persistent endometrial cancer. The main protocol provides a platform for genomic screening ...

What is the current status of trial NCT04486352?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 148 participants. The study started on 2021-10-20. Estimated completion is 2027-10.

What conditions does trial NCT04486352 study?

This clinical trial studies the following conditions: Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04486352?

The interventions under investigation include: Bevacizumab (DRUG), Ipatasertib (DRUG), Talazoparib (DRUG), Atezolizumab - 28 Day Cycle (DRUG), Trastuzumab emtansine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04486352?

This trial is sponsored by Alliance Foundation Trials, which has 71 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04486352 being conducted?

This trial has 20 study locations across California, District of Columbia, Florida, Illinois, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial