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A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors
NCT05787587 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to characterize the safety, tolerability, and efficacy of IDE161 as a single agent and in combination with pembrolizumab.
Conditions Studied
Interventions
- DRUG Pembrolizumab
- DRUG IDE-161
Study Locations (20)
California
- The Angeles Clinic — Los Angeles
- Hoag Memorial Hospital — Newport Beach
- California Pacific Medical Center — San Francisco
New York
- Roswell Park Comprehensive Cancer Center — Buffalo
- Columbia University Medical Center — New York
- Weil Cornell University — New York
Pennsylvania
- University of Pennsylvania — Philadelphia
- Sarah Cannon Research Institute - Thomas Jefferson University — Philadelphia
Arizona
- HonorHealth Research Institute — Phoenix
Colorado
- Sarah Cannon Research Institute — Denver
Connecticut
- Yale University — New Haven
Florida
- Orlando Health — Orlando
Georgia
- Emory University — Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 216 participants |
| Start Date | 2023-04-18 |
| Est. Completion | 2027-05 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05787587
The ClinicalTrials.gov registry entry for NCT05787587 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 216 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is IDEAYA Biosciences, which has 36 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 9 conditions, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05787587 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, New York, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05787587 about?
NCT05787587 is a clinical study titled "A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors". The purpose of this study is to characterize the safety, tolerability, and efficacy of IDE161 as a single agent and in combination with pembrolizumab.
What is the current status of trial NCT05787587?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 216 participants. The study started on 2023-04-18. Estimated completion is 2027-05.
What conditions does trial NCT05787587 study?
This clinical trial studies the following conditions: Breast Cancer, Prostate Cancer, Colorectal Cancer, Ovarian Cancer, Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05787587?
The interventions under investigation include: Pembrolizumab (DRUG), IDE-161 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05787587?
This trial is sponsored by IDEAYA Biosciences, which has 36 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05787587 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Connecticut, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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