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RECRUITING Phase 3

Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer

NCT07166094 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to compare how well Rina-S (GEN1184) works compared to treatment of physician's choice (paclitaxel or doxorubicin) that are considered standard medical care for the treatment of recurrent or progressive endometrial cancer (EC) following prior therapy. There is an equal (50:50) chance of getting either Rina-S or a chemotherapy agent as treatment in this study. The study duration will be approximately 3 years. The treatment duration will be different for every participant, but an average of 4 to 6 months is expected. All participants will receive active drug; no one will be given placebo. Participation in the study will require visits to the study site(s).

Interventions

  • DRUG Rina-S
  • DRUG IC

Study Locations (20)

Minnesota

  • USOR - Minnesota Oncology/ Coon Rapids Clinic — Coon Rapids
  • USOR - Minnesota Oncology/Edina Clinic — Edina
  • USOR - Minnesota Oncology/ Maple Grove Clinic — Maple Grove
  • USOR - Minnesota Oncology/ Maplewood Clinic — Maplewood
  • USOR - Minnesota Oncology/ Minneapolis Clinic — Minneapolis
  • USOR - Minnesota Oncology/ Woodbury Clinic — Woodbury

Oregon

  • Willamette Valley Cancer Institute and Research Center - Eugene — Eugene
  • NW Cancer Specs. P.C. — Happy Valley
  • USOR - NW Cancer Specs P.C. — Portland
  • USOR - NW Cancer Specs. P.C. — Tigard

Georgia

  • Emory Winship Cancer Inst. — Atlanta
  • Emory Winship Cancer Inst. — Atlanta
  • Emory Winship Cancer Inst./Emory Decatur Hospital — Decatur

Texas

  • TX Onc - Arlington North — Arlington
  • USOR - Texas Oncology — Austin
  • USOR - Texas Oncology — Austin

Maryland

  • Sinai Hospital — Baltimore
  • William Kahlert Reg. Can. Ctr — Westminster

Florida

  • SMH - Sarasota - Main Campus — Sarasota

Louisiana

  • Trials365, LLC — Shreveport

Trial Details

FieldValue
Enrollment Target 544 participants
Start Date 2025-11-28
Est. Completion 2029-02
Phase Phase 3

Sponsor

Genmab

59 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07166094

The ClinicalTrials.gov registry entry for NCT07166094 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 544 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Genmab, which has 59 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Endometrial Cancer appearing as the primary indexed condition, and to 2 interventions — of which Rina-S is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07166094 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Minnesota, Oregon, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07166094 about?

NCT07166094 is a clinical study titled "Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer". The purpose of this study is to compare how well Rina-S (GEN1184) works compared to treatment of physician's choice (paclitaxel or doxorubicin) that are considered standard medical care for the treatment of recurrent or progressive endometrial cancer (EC) following prior therapy. There is an equal (...

What is the current status of trial NCT07166094?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 544 participants. The study started on 2025-11-28. Estimated completion is 2029-02.

What conditions does trial NCT07166094 study?

This clinical trial studies the following conditions: Endometrial Cancer, Recurrent or Progressive Endometrial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07166094?

The interventions under investigation include: Rina-S (DRUG), IC (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07166094?

This trial is sponsored by Genmab, which has 59 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07166094 being conducted?

This trial has 20 study locations across Florida, Georgia, Louisiana, Maryland, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial