Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose cotransporter-2 inhibitor (SGLT2i). The study will last about 26 months and may include up to 24 visits.
Conditions Studied
Interventions
- DRUG Semaglutide
- DRUG Retatrutide
Study Locations (20)
California
- Neighborhood Healthcare Institute of Health — Escondido
- Long Beach Research Institute — Long Beach
- Valley Clinical Trials, Inc. — Northridge
- Rancho Cucamonga Clinical Research — Rancho Cucamonga
Florida
- Arrow Clinical Trials — Daytona Beach
- New Age Medical Research Corporation — Miami
- South Broward Research — Miramar
- Clinical Research of Central Florida — Winter Haven
Georgia
- Herman Clinical Research — Suwanee
- North Georgia Clinical Research — Woodstock
Massachusetts
- Brigham and Women's Hospital Diabetes Program — Boston
- NECCR PrimaCare Research — Fall River
Alabama
- University of Alabama - Department of Nutrition Sciences — Birmingham
Colorado
- University of Colorado Anschutz Medical Campus — Aurora
Hawaii
- Pacific Diabetes & Endocrine Center — Honolulu
Idaho
- Rocky Mountain Clinical Research — Idaho Falls
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,250 participants |
| Start Date | 2024-02-21 |
| Est. Completion | 2027-01 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06260722
The ClinicalTrials.gov registry entry for NCT06260722 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Diabetes Mellitus, Type 2 appearing as the primary indexed condition, and to 2 interventions — of which Semaglutide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06260722 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06260722 about?
NCT06260722 is a clinical study titled "Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)". The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose cotransporter-2 inhibitor (SGLT2i). The study will last about 26 months and ...
What is the current status of trial NCT06260722?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,250 participants. The study started on 2024-02-21. Estimated completion is 2027-01.
What conditions does trial NCT06260722 study?
This clinical trial studies the following conditions: Diabetes Mellitus, Type 2. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06260722?
The interventions under investigation include: Semaglutide (DRUG), Retatrutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06260722?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06260722 being conducted?
This trial has 20 study locations across Alabama, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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