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NCT01762046 · ClinicalTrials.gov registry record · Phase 1
Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans
A Phase 1 study of Diabetes Mellitus, Type 2, sponsored by Massachusetts General Hospital.
- Active
- Registry status
- Phase 1
- Development phase
- 1,033
- Enrollment target
- 3
- Study locations
NCT01762046: Active Phase 1 study of Diabetes Mellitus, Type 2, sponsored by Massachusetts General Hospital.
NCT01762046 is a Phase 1 study of Diabetes Mellitus, Type 2 that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 1,033 participants, below the 4,482-participant average among 348 other Diabetes Mellitus, Type 2 trials with a reported enrollment target (77% lower). The trial reports 3 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01762046, a Phase 1 study of Diabetes Mellitus, Type 2, is active but no longer recruiting, sponsored by Massachusetts General Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 1,033 participants
- Enrollment target
- 3
- Study locations
Study Summary
The SUGAR-MGH investigators are studying the influence of inherited gene variants on the response to two commonly prescribed type 2 diabetes medications, metformin and glipizide. They hypothesize that variants in genes that are associated with type 2 diabetes or related traits may impact the effect of anti-diabetic medications. In addition, physiological responses to an insulin secretagogue or an insulin sensitizer may shed light on the mechanism of action of reported genetic associations.
Primary Outcome
Investigators will measure glucose levels at 0,30,60,90,120,180 and 240 minutes post 5mg Glipizide administration on Visit 1(Day1), and compare them by genotype at selected loci.
Conditions Studied
Interventions
- DRUG Metformin
- DRUG Glipizide
- OTHER Oral Glucose Tolerance Test
Study Locations (3)
Massachusetts
- Massachusetts General Hospital - Boston
- Brigham and Women's Hospital - Boston
- Joslin Diabetes Center - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,033 participants |
| Start Date | 2008-01 |
| Est. Completion | 2025-12 |
| Phase | Phase 1 |
What the registry record for NCT01762046 still lists
NCT01762046 is an interventional study that assigns participants to a tested intervention. Its 1,033 participants enrollment target places it among the larger protocols in the corpus, below the 4,482-participant average among 348 other Diabetes Mellitus, Type 2 trials with a reported enrollment target (77% lower).
The record links to 1 condition, with Diabetes Mellitus, Type 2 appearing as the primary indexed condition, and to 3 interventions - of which Metformin is the first listed.
NCT01762046 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT01762046 about?
NCT01762046 is a clinical study titled "Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans". The SUGAR-MGH investigators are studying the influence of inherited gene variants on the response to two commonly prescribed type 2 diabetes medications, metformin and glipizide. They hypothesize that variants in genes that are associated with type 2 diabetes or related traits may impact the effect ...
What is the current status of trial NCT01762046?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 1,033 participants. The study started on 2008-01. Estimated completion is 2025-12.
What conditions does trial NCT01762046 study?
This clinical trial studies the following conditions: Diabetes Mellitus, Type 2.
What interventions are being tested in trial NCT01762046?
The interventions under investigation include: Metformin (DRUG), Glipizide (DRUG), Oral Glucose Tolerance Test (OTHER).
Who is sponsoring clinical trial NCT01762046?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01762046 being conducted?
This trial has 3 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Diabetes Mellitus, Type 2
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01762046's enrollment target sits among peer trials
1,033 33rd of 348 higher than 316 of 348 other Diabetes Mellitus, Type 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes Mellitus, Type 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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