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NCT06623396 · ClinicalTrials.gov registry record · Phase 1
A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer
A Phase 1 study of Diabetes Mellitus and Breast Neoplasms, sponsored by Memorial Sloan Kettering Cancer Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 18
- Enrollment target
- 7
- Study locations
NCT06623396: Recruiting Phase 1 study of Diabetes Mellitus and Breast Neoplasms, sponsored by Memorial Sloan Kettering Cancer Center.
NCT06623396 is a Phase 1 study of Diabetes Mellitus and Breast Neoplasms that is actively recruiting participants, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 18 participants, below the 1,867-participant average among 208 other Diabetes Mellitus trials with a reported enrollment target (99% lower). The trial reports 7 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06623396, a Phase 1 study of Diabetes Mellitus and Breast Neoplasms, is actively recruiting participants, sponsored by Memorial Sloan Kettering Cancer Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 18 participants
- Enrollment target
- 7
- Study locations
Study Summary
Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory at Memorial Sloan Kettering to be changed (modified) to become MSLN-targeted CAR T cells, the CAR T-cell therapy that participants will receive during the study. Participant study therapy will take about 3-4 weeks.
Primary Outcome
The primary objective of this study is to assess the safety of M28z1XXPD1DNR CAR T cells administered through the peritoneal cavity. CTCAE v5.0 will be used to assess the severity of all treatment-emergent toxicities and adverse events, regardless of reporting requirements
Conditions Studied
Interventions
- BIOLOGICAL M28z1XXPD1DNR CAR
Study Locations (7)
New York
- Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities) - Commack
- Memorial Sloan Kettering Westchester (Limited Protocol Activities) - Harrison
- Memorial Sloan Kettering Cancer Center (All Protocol Activities) - New York
- Memorial Sloan Kettering Nassau (Limited Protocol Activities) - Uniondale
New Jersey
- Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities) - Basking Ridge
- Memorial Sloan Kettering Monmouth (Limited protocol activities) - Middletown
- Memorial Sloan Kettering Bergen (Limited Protocol Activities) - Montvale
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2024-09-30 |
| Est. Completion | 2028-09-30 |
| Phase | Phase 1 |
What NCT06623396 shows while recruiting
NCT06623396 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 18 participants, a relatively small participant target, below the 1,867-participant average among 208 other Diabetes Mellitus trials with a reported enrollment target (99% lower).
The record links to 8 conditions, with Diabetes Mellitus appearing as the primary indexed condition, and to 1 intervention - of which M28z1XXPD1DNR CAR is the first listed.
NCT06623396 lists 7 locations in 2 states (New York, New Jersey).
Frequently Asked Questions
What is clinical trial NCT06623396 about?
NCT06623396 is a clinical study titled "A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer". Participants will have a sample of their white blood cells, called T cells, collected using a procedure called leukapheresis. The collected T cells will be sent to a laboratory at Memorial Sloan Kettering to be changed (modified) to become MSLN-targeted CAR T cells, the CAR T-cell therapy that parti...
What is the current status of trial NCT06623396?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2024-09-30. Estimated completion is 2028-09-30.
What conditions does trial NCT06623396 study?
This clinical trial studies the following conditions: Diabetes Mellitus, Breast Neoplasms, Esophageal Adenocarcinoma, Peritoneal Carcinomatosis, Mesothelin-Expressing Tumors.
What interventions are being tested in trial NCT06623396?
The interventions under investigation include: M28z1XXPD1DNR CAR (BIOLOGICAL).
Who is sponsoring clinical trial NCT06623396?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06623396 being conducted?
This trial has 7 study locations across New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06623396's enrollment target sits among peer trials
18 199th of 208 higher than 10 of 208 other Diabetes Mellitus trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diabetes Mellitus trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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