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Diabetes Mellitus clinical trials
49 of 210 indexed Diabetes Mellitus trials are currently recruiting.
210 US clinical trials · 49 currently recruiting
Diabetes Mellitus is the subject of 210 registered US clinical trials on ClinicalTrials.gov, 49 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 32 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 8 of these trials.
The research picture
Diabetes Mellitus has 210 registered US clinical trials, 49 of them open to new participants right now, about 23% of the total.
- 49
- recruiting participants now
- 23%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 8
- top sponsor: Takeda
Active & Recent Trials
210 total, page 2 of 5
Cardiovascular Health Study (CHS)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00005133
Eat Well Produce Benefit for Diabetes and Food Insecurity
Duke University
NCT05896644
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
Medtronic Vascular
NCT05198674
Dissemination of the Cardiovascular Risk Service
Korey Kennelty
NCT03660631
Biological Sample Repository for Gastrointestinal Disorders
Pichamol Jirapinyo, MD, MPH
NCT05874726
Eat, Move, Live Program for the Reduction of Cancer and Chronic Disease Risk in Underserved Communities
City of Hope Medical Center
NCT05414396
Oral Anti Diabetic Agents in the Hospital
Emory University
NCT04416269
Texting for Diabetes
St. Louis University
NCT03025984
The REST Study for CGM Use in Older Adults With Insulin-treated Diabetes
Joslin Diabetes Center
NCT05337826
People With CHC Who Achieved a Sustained Virological Response Following Therapy With Direct Acting Antiviral Agents
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT03520660
Black Girls Move Physical Activity and Improving Dietary Intake Among Black Adolescent Daughters
Rush University Medical Center
NCT05433415
Glucose Metabolism in Sickle Cell Disease
University of Illinois at Chicago
NCT02922296
A Sugar-Sweetened Beverage Reduction Intervention for Native American Men
Roswell Park Cancer Institute
NCT06029517
Continuous Glucose Monitoring of Hospitalized Patients With Diabetes
Baylor Research Institute
NCT04230694
Glycemic Emergency Management (GEM); An App for Rapid Response to Hypoglycemic and Hyperglycemic Situations
Marshall University
NCT02336217
Food is Medicine vs Lifestyle Medicine For Cardiovascular Kidney Metabolic (CKM) Syndrome
Rutgers, The State University of New Jersey
NCT06461273
Study of a Primary Care Hypoglycemia Prevention Program
Johns Hopkins University
NCT06353217
Community Health Workers in Pediatric Patients With Newly Diagnosed Type 1 Diabetes
Children's Hospital of Philadelphia
NCT04238949
Plant-based Diet for Kidney Transplant Recipients
George Washington University
NCT06186843
Enhancing Mental and Physical Health of Women Veterans
VA Office of Research and Development
NCT05050266
Islet Transplantation Alone (ITA) in Patients With Difficult to Control Type I Diabetes Mellitus Using a Glucocorticoid-free Immunosuppressive Regimen
City of Hope Medical Center
NCT00706420
Evaluation of VLER-Indiana Health Information Exchange Demonstration Project
VA Office of Research and Development
NCT01446705
Evaluating the Navajo Community Outreach and Patient Empowerment (COPE) Program
Brigham and Women's Hospital
NCT03326206
Evaluation of a Dashboard for Diabetes Care Integrated With the Electronic Health Record
University of Utah
NCT03826290
Action to Control Cardiovascular Risk in Diabetes (ACCORD)
National Heart, Lung, and Blood Institute (NHLBI)
NCT00000620
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications
University of Colorado, Denver
NCT03973931
Blood Glucose Monitoring in Electronic Health Records
Inova Health Care Services
NCT03542487
Improving Diabetes in Primary Care (IMPACT)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00108927
Clinical Decision Support for Medication Management and Adherence
Duke University
NCT00979225
Glucose to Goal: A Model to Support Diabetes Management in Primary Care
University of Pittsburgh
NCT02715934
Improving Quality With Outpatient Decision Support
Agency for Healthcare Research and Quality (AHRQ)
NCT00225628
Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes
US Department of Veterans Affairs
NCT00119535
Randomized Trial of Telemedicine for Diabetes Care
Columbia University
NCT00271739
Diabetes-Depression Care-management Adoption Trial
University of Southern California
NCT01781013
A Clinical Trial Assessing the Impact of the Availability of Inhaled Insulin on Glucose Control
Pfizer
NCT00134147
Efficacy of Alogliptin and Pioglitazone in Subjects With Type 2 Diabetes Mellitus
Takeda
NCT00432276
Integrating Community Health Workers to Improve Diabetes Prevention
NYU Langone Health
NCT03006666
CV Disease in Adolescents With Type 2 Diabetes
Children's Hospital Medical Center, Cincinnati
NCT00114998
Study to Compare Pioglitazone and Rosiglitazone in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia
Takeda
NCT00331487
Cebranopadol Efficacy and Safety in Diabetic Patients Suffering From Chronic Pain Caused by Damage to the Nerves
Tris Pharma
NCT01939366
Phase 3 28-Week Study With 24-Week and 52-week Extension Phases to Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching Placebo
AstraZeneca
NCT02229396
Meals MATTER: A Trial of Medically Tailored Meals 2 Weeks vs. 4 Weeks Post Hospital Discharge
Kaiser Permanente
NCT04351880
Evaluation of the Analytical Performance of ALLEGRO™ Instrument
Nova Biomedical
NCT04096313
Screening for Patients Needing Kidney, Kidney-Pancreas, or Islet-Cell Transplant
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00001859
Efficacy and Safety of Pioglitazone and Metformin Combination Therapy in Treating Type 2 Diabetes Mellitus.
Takeda
NCT00727857
Effect of Care Management on Diabetes Outcomes
Minneapolis Veterans Affairs Medical Center
NCT00569556
Multidisciplinary Inpatient Palliative Care Intervention
Kaiser Permanente
NCT00325611
Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus
Takeda
NCT00225277
User Evaluation of the Invasive Component of the CNOGA TensorTip COMBO GLUCOMETER (CoG)
Sciema UG
NCT03870971
Efficacy and Safety of Alogliptin Combined With Metformin in Participants With Type 2 Diabetes Mellitus
Takeda
NCT00286442
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 13 |
| Phase 2 | 19 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Diabetes Mellitus Trial Landscape
210 indexed Diabetes Mellitus studies · 49 recruiting (23%).
Phase mix: 26 late (III/IV) vs 32 early (I/II).
Top sponsor: Takeda (8 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Diabetes Mellitus?
PlainTrial tracks 210 US clinical trials for Diabetes Mellitus, of which 49 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Diabetes Mellitus?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.