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NCT06647498 · ClinicalTrials.gov registry record · Phase 2
A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation
A Phase 2 study of Dementia and Alzheimers Disease, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 280
- Enrollment target
- 20
- Study locations
NCT06647498 is a Phase 2 study of Dementia and Alzheimers Disease that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 280 participants, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (96% lower). The trial reports 20 study locations across 18 states.
The verdict
NCT06647498, a Phase 2 study of Dementia and Alzheimers Disease, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 280 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing mutations. This study will also investigate the effects of remternetug on biomarkers (measures of the disease including brain scans, blood and spinal fluid tests), examine safety data to identify any potential benefits or risks, and examine how well participants can tolerate remternetug. Stage 1 will determine if treatment with the study drug prevents or reverses amyloid beta (Aβ) accumulation compared with placebo in participants with dominantly inherited Alzheimer's disease (DIAD). Stage 2 will evaluate the effect of early anti-amyloid treatment on downstream biomarkers of AD in treated participants compared to external control groups.
Conditions Studied
Interventions
- DRUG Remternetug
- DRUG Matching Placebo (Remternetug)
Study Locations (20)
Other
- Instituto de Investigaciones Neurologicas Raul Carrea, FLENI - Ciudad Autonoma de Buenos Aire
- CHU de Quebec - Hôpital de l' Enfant Jésus - Québec
- Grupo de Neurociencias Sede de la Universidad de Antioquia - Medellín
Alabama
- University of Alabama in Birmingham - Birmingham
California
- University of California San Diego Medical Center - La Jolla
Connecticut
- Yale University School of Medicine - New Haven
Georgia
- Emory University - Atlanta
Illinois
- Advocate Lutheran General Hospital - Park Ridge
Indiana
- Indiana University School of Medicine - Indianapolis
Missouri
- Washington University in St. Louis - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 280 participants |
| Start Date | 2024-11-22 |
| Est. Completion | 2034-08 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06647498
The ClinicalTrials.gov registry entry for NCT06647498 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 280 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 7,722-participant average among 199 other Dementia trials with a reported enrollment target (96% lower). The listed sponsor is Washington University School of Medicine, which has 1,502 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Dementia appearing as the primary indexed condition, and to 2 interventions - of which Remternetug is the first listed.
NCT06647498 reports 20 study locations spanning 18 distinct geographic areas - top geographies include Other, Alabama, California.
Frequently Asked Questions
What is clinical trial NCT06647498 about?
NCT06647498 is a clinical study titled "A Study of a Potential Disease Modifying Treatment in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation". The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer disease in individuals with AD-causing mutations. This study will also investigate the effects of remternetug on biomar...
What is the current status of trial NCT06647498?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 280 participants. The study started on 2024-11-22. Estimated completion is 2034-08.
What conditions does trial NCT06647498 study?
This clinical trial studies the following conditions: Dementia, Alzheimers Disease, Alzheimers Disease, Familial.
What interventions are being tested in trial NCT06647498?
The interventions under investigation include: Remternetug (DRUG), Matching Placebo (Remternetug) (DRUG).
Who is sponsoring clinical trial NCT06647498?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06647498 being conducted?
This trial has 20 study locations across Alabama, California, Connecticut, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.