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NCT07226115 · ClinicalTrials.gov registry record
Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer
A clinical trial of Colorectal Cancer and Colorectal Cancer Stage II, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- 200
- Enrollment target
- 1
- Study location
NCT07226115: Recruiting study of Colorectal Cancer and Colorectal Cancer Stage II, sponsored by City of Hope Medical Center.
NCT07226115 is a study of Colorectal Cancer and Colorectal Cancer Stage II that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 200 participants, below the 1,544-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07226115, a study of Colorectal Cancer and Colorectal Cancer Stage II, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Although adjuvant chemotherapy improves survival after curative resection, its efficacy varies widely among patients. The absence of reliable predictive biomarkers often leads to overtreatment or undertreatment. This study aims to develop a machine learning-based predictive model for adjuvant chemotherapy response using tumor-derived alternative splicing signatures. By integrating RNA-seq data, splicing isoform and clinical outcomes, this study seeks to identify molecular predictors of treatment response and recurrence risk after surgery.
Primary Outcome
Time from disease treatment to development of recurrent colorectal cancer
Conditions Studied
Interventions
- OTHER SPLICE
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2024-06-21 |
| Est. Completion | 2026-06-18 |
What NCT07226115 shows while recruiting
NCT07226115 is an observational study that tracks outcomes without assigning an intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 1,544-participant average among 381 other Colorectal Cancer trials with a reported enrollment target (87% lower).
The record links to 4 conditions, with Colorectal Cancer appearing as the primary indexed condition, and to 1 intervention - of which SPLICE is the first listed.
NCT07226115 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT07226115 about?
NCT07226115 is a clinical study titled "Splicing-based Predictive Learning for Individual Chemotherapy Evaluation in Colorectal Cancer". Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Although adjuvant chemotherapy improves survival after curative resection, its efficacy varies widely among patients. The absence of reliable predictive biomarkers often leads to overtreatment or undertr...
What is the current status of trial NCT07226115?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2024-06-21. Estimated completion is 2026-06-18.
What conditions does trial NCT07226115 study?
This clinical trial studies the following conditions: Colorectal Cancer, Colorectal Cancer Stage II, Colorectal Cancer Stage III, Colorectal Cancer Recurrent.
What interventions are being tested in trial NCT07226115?
The interventions under investigation include: SPLICE (OTHER).
Who is sponsoring clinical trial NCT07226115?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07226115 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Colorectal Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07226115's enrollment target sits among peer trials
200 147th of 381 higher than 230 of 381 other Colorectal Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Colorectal Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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