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NCT07103135 · ClinicalTrials.gov registry record · Phase 1
Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling
A Phase 1 study of Chronic Pain, sponsored by University of Minnesota.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT07103135: Recruiting Phase 1 study of Chronic Pain, sponsored by University of Minnesota.
NCT07103135 is a Phase 1 study of Chronic Pain that is actively recruiting participants, run by University of Minnesota. The registered enrollment target is 30 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07103135, a Phase 1 study of Chronic Pain, is actively recruiting participants, sponsored by University of Minnesota.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to evaluate the safety and efficacy of accelerated intermittent theta burst stimulation (aiTBS) targeting personalized nodes within the somato-cognitive action network (SCAN) and action motor network (AMN) for the treatment of chronic pain. The study will employ Thompson Sampling, a Bayesian reinforcement learning algorithm, to optimize stimulation site selection based on individual response patterns. This approach has the potential to revolutionize pain management by improving treatment accessibility through shortened timelines, addressing individual variations in pain networks through precision targeting, and potentially achieving more robust pain relief through accelerated neuroplasticity. The specific aims of the study are: 1. To establish the relationship between SCAN and AMN connectivity and cognitive- affective pain symptoms. 2. To evaluate the efficacy of Thompson Sampling-optimized aiTBS across SCAN and AMN on affective and sensorimotor pain dimensions. 3. To identify fMRI connectivity biomarkers predictive of treatment response and remission.
Primary Outcome
measured by the Numerical Rating Scale (NRS) from baseline to after completion of the trial (approximately 3 months). For the NRS, the scores range from 0 to 10, where 0 indicates no pain (better outcome) and 10 is the worst pain that the participant can imagine (worse outcome)
Conditions Studied
Interventions
- DEVICE MagVenture X100 Pro transcranial magnetic stimulation system
Study Locations (1)
Minnesota
- University of Minnesota - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2026-03-01 |
| Est. Completion | 2030-08-31 |
| Phase | Phase 1 |
What NCT07103135 shows while recruiting
NCT07103135 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Chronic Pain appearing as the primary indexed condition, and to 1 intervention - of which MagVenture X100 Pro transcranial magnetic stimulation system is the first listed.
NCT07103135 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT07103135 about?
NCT07103135 is a clinical study titled "Optimizing Accelerated TMS for Chronic Pain With Thompson Sampling". The purpose of this study is to evaluate the safety and efficacy of accelerated intermittent theta burst stimulation (aiTBS) targeting personalized nodes within the somato-cognitive action network (SCAN) and action motor network (AMN) for the treatment of chronic pain. The study will employ Thompson...
What is the current status of trial NCT07103135?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2026-03-01. Estimated completion is 2030-08-31.
What conditions does trial NCT07103135 study?
This clinical trial studies the following conditions: Chronic Pain.
What interventions are being tested in trial NCT07103135?
The interventions under investigation include: MagVenture X100 Pro transcranial magnetic stimulation system (DEVICE).
Who is sponsoring clinical trial NCT07103135?
This trial is sponsored by University of Minnesota, which has 966 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07103135 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07103135's enrollment target sits among peer trials
30 244th of 301 higher than 48 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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