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NCT06100822 · ClinicalTrials.gov registry record · Phase 1
Managing Chronic Tendon Pain by Metformin
A Phase 1 study of Chronic Pain and Tendinopathy, sponsored by James Wang.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06100822: Recruiting Phase 1 study of Chronic Pain and Tendinopathy, sponsored by James Wang.
NCT06100822 is a Phase 1 study of Chronic Pain and Tendinopathy that is actively recruiting participants, run by James Wang. The registered enrollment target is 40 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06100822, a Phase 1 study of Chronic Pain and Tendinopathy, is actively recruiting participants, sponsored by James Wang.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM capsules on tendon healing and repair. Twenty participants will be treated with metformin capsules for 16 weeks combined with a home exercise program. A comparison group of 20 participants will be treated with placebo tablets along with home exercise program.
Primary Outcome
The VISA-A is a self-administered questionnaire that asks about Achilles tendon pain, function, and activity. Scores range from 0 to 100 with a low score indicating more severe pain.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Metformin
Study Locations (1)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-05-24 |
| Est. Completion | 2026-08 |
| Phase | Phase 1 |
What NCT06100822 shows while recruiting
NCT06100822 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (95% lower).
The record links to 3 conditions, with Chronic Pain appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06100822 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06100822 about?
NCT06100822 is a clinical study titled "Managing Chronic Tendon Pain by Metformin". The purpose of the current exploratory clinical trial is to determine the effect of oral ingestion of metformin (OIM) in non-diabetic patients with chronic Achilles tendon pain. The trial has two aims; 1) to assess the effects of OIM treatment on tendon pain, and 2) to determine the effects of OIM c...
What is the current status of trial NCT06100822?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 40 participants. The study started on 2024-05-24. Estimated completion is 2026-08.
What conditions does trial NCT06100822 study?
This clinical trial studies the following conditions: Chronic Pain, Tendinopathy, Achilles Tendinopathy.
What interventions are being tested in trial NCT06100822?
The interventions under investigation include: Placebo (DRUG), Metformin (DRUG).
Who is sponsoring clinical trial NCT06100822?
This trial is sponsored by James Wang, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06100822 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06100822's enrollment target sits among peer trials
40 214th of 301 higher than 81 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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