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NCT06442566 · ClinicalTrials.gov registry record · Phase 1
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
A Phase 1 study of Chronic Pain and Opioid Withdrawal, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 240
- Enrollment target
- 1
- Study location
NCT06442566: Recruiting Phase 1 study of Chronic Pain and Opioid Withdrawal, sponsored by Medical University of South Carolina.
NCT06442566 is a Phase 1 study of Chronic Pain and Opioid Withdrawal that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 240 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (69% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06442566, a Phase 1 study of Chronic Pain and Opioid Withdrawal, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); and (3) "accelerated" rTMS over the left dorsolateral prefrontal cortex, by examining standardized repeated measures of clinical outcomes at baseline, during treatment, and at 4-, 12-, 24- and 52-week follow-up.
Primary Outcome
Tolerability of open-label transdermal buprenorphine. Buprenorphine tolerability defined as the proportion of patients who do not discontinue buprenorphine due to adverse effects or intolerance.
Conditions Studied
Interventions
- DRUG Placebo
- DEVICE Transcranial Magnetic Stimulation (TMS)
- DRUG Buprenorphine Patch
- DEVICE Sham Transcranial Magnetic Stimulation (TMS)
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2024-08-12 |
| Est. Completion | 2029-03-31 |
| Phase | Phase 1 |
What NCT06442566 shows while recruiting
NCT06442566 is an interventional study that assigns participants to a tested intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (69% lower).
The record links to 2 conditions, with Chronic Pain appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT06442566 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT06442566 about?
NCT06442566 is a clinical study titled "ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain". This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); an...
What is the current status of trial NCT06442566?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 240 participants. The study started on 2024-08-12. Estimated completion is 2029-03-31.
What conditions does trial NCT06442566 study?
This clinical trial studies the following conditions: Chronic Pain, Opioid Withdrawal.
What interventions are being tested in trial NCT06442566?
The interventions under investigation include: Placebo (DRUG), Transcranial Magnetic Stimulation (TMS) (DEVICE), Buprenorphine Patch (DRUG), Sham Transcranial Magnetic Stimulation (TMS) (DEVICE).
Who is sponsoring clinical trial NCT06442566?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06442566 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Pain
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06442566's enrollment target sits among peer trials
240 68th of 301 higher than 231 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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