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NCT06442566 · ClinicalTrials.gov registry record · Phase 1
ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain
A Phase 1 study of Chronic Pain and Opioid Withdrawal, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 240
- Enrollment target
- 1
- Study location
NCT06442566 is a Phase 1 study of Chronic Pain and Opioid Withdrawal that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 240 participants, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (69% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06442566, a Phase 1 study of Chronic Pain and Opioid Withdrawal, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); and (3) "accelerated" rTMS over the left dorsolateral prefrontal cortex, by examining standardized repeated measures of clinical outcomes at baseline, during treatment, and at 4-, 12-, 24- and 52-week follow-up.
Conditions Studied
Interventions
- DRUG Placebo
- DEVICE Transcranial Magnetic Stimulation (TMS)
- DRUG Buprenorphine Patch
- DEVICE Sham Transcranial Magnetic Stimulation (TMS)
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2024-08-12 |
| Est. Completion | 2029-03-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06442566
The ClinicalTrials.gov registry entry for NCT06442566 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 772-participant average among 301 other Chronic Pain trials with a reported enrollment target (69% lower). The listed sponsor is Medical University of South Carolina, which has 755 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Chronic Pain appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT06442566 reports 1 study location spanning 1 distinct geographic area - top geographies include South Carolina.
Frequently Asked Questions
What is clinical trial NCT06442566 about?
NCT06442566 is a clinical study titled "ACTION: Trial of Adding Buprenorphine, CBT, and TMS to Improve Outcomes of Long-Term Opioid Therapy for Chronic Pain". This study will sequentially evaluate three novel and scalable interventions for at-risk individuals on long term opioid therapy for chronic pain: (1) low-dose transdermal buprenorphine initiation without a period of opioid withdrawal; (2) a brief Cognitive Behavioral Intervention for pain (CBI); an...
What is the current status of trial NCT06442566?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 240 participants. The study started on 2024-08-12. Estimated completion is 2029-03-31.
What conditions does trial NCT06442566 study?
This clinical trial studies the following conditions: Chronic Pain, Opioid Withdrawal.
What interventions are being tested in trial NCT06442566?
The interventions under investigation include: Placebo (DRUG), Transcranial Magnetic Stimulation (TMS) (DEVICE), Buprenorphine Patch (DRUG), Sham Transcranial Magnetic Stimulation (TMS) (DEVICE).
Who is sponsoring clinical trial NCT06442566?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06442566 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.