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NCT06574009 · ClinicalTrials.gov registry record · Phase 4
Better Options for Chronic Cancer Pain
A Phase 4 study of Chronic Pain and Opioid Dependence, sponsored by VA Office of Research and Development.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 294
- Enrollment target
- 2
- Study locations
NCT06574009: Recruiting Phase 4 study of Chronic Pain and Opioid Dependence, sponsored by VA Office of Research and Development.
NCT06574009 is a Phase 4 study of Chronic Pain and Opioid Dependence that is actively recruiting participants, run by VA Office of Research and Development. The registered enrollment target is 294 participants, below the 771-participant average among 301 other Chronic Pain trials with a reported enrollment target (62% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06574009, a Phase 4 study of Chronic Pain and Opioid Dependence, is actively recruiting participants, sponsored by VA Office of Research and Development.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 294 participants
- Enrollment target
- 2
- Study locations
Study Summary
This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the VHA, placing them at risk of opioid addiction and overdose, and other opioid-related problems. Yet, there are no programs at the VHA to help them find alternatives to opioids, nor evidence to inform the choice of interventions. This study will meet these needs by examining four interventions that are effective at reducing opioid use in patients with chronic musculoskeletal pain but have yet to be tested in cancer survivors on long term opioid therapy. The proposed work is relevant to the VHA Pain Office's mission to provide Veterans better pain management while limiting the risks of long-term opioid therapy and it aligns with VHA Research and Development's priority to examine clinical interventions for tapering opioids. Successful completion this project will keep VHA at the forefront of the battle against the opioid epidemic with a strategy that may be adapted to address the same needs in non-Veterans.
Primary Outcome
The primary outcome is a composite variable which combines one objective outcome (opioid dose reduction) and one subjective outcome (pain interference) to reflect two outcomes of equal importance to Veterans. Veterans will be considered as achieving this outcome if they experience 20% reduction in opioid daily dose (in MEDD) from baseline and no worsening of pain interference by more than 1 point on the Pain Enjoyment of Life and General Activity (PEG) score.
Conditions Studied
Interventions
- BEHAVIORAL Multimodal pain care
- DRUG Medication optimization
- DEVICE Buprenorphine rotation
- OTHER Opioid tapering
Study Locations (2)
Indiana
- Richard L. Roudebush VA Medical Center, Indianapolis, IN - Indianapolis
Michigan
- VA Ann Arbor Healthcare System, Ann Arbor, MI - Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 294 participants |
| Start Date | 2025-10-07 |
| Est. Completion | 2029-12-31 |
| Phase | Phase 4 |
What NCT06574009 shows while recruiting
NCT06574009 is an interventional study that assigns participants to a tested intervention. The registered 294 participants enrollment target is mid-sized for trials with a published cap, below the 771-participant average among 301 other Chronic Pain trials with a reported enrollment target (62% lower).
The record links to 3 conditions, with Chronic Pain appearing as the primary indexed condition, and to 4 interventions - of which Multimodal pain care is the first listed.
NCT06574009 reports a single indexed study location in Indiana, Michigan.
Frequently Asked Questions
What is clinical trial NCT06574009 about?
NCT06574009 is a clinical study titled "Better Options for Chronic Cancer Pain". This proposal is relevant to the 240,000 cancer survivors who continue to use opioids long after they have successfully completed treatment for cancer at the VHA, placing them at risk of opioid addiction and overdose, and other opioid-related problems. Yet, there are no programs at the VHA to help t...
What is the current status of trial NCT06574009?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 294 participants. The study started on 2025-10-07. Estimated completion is 2029-12-31.
What conditions does trial NCT06574009 study?
This clinical trial studies the following conditions: Chronic Pain, Opioid Dependence, Cancer Survivor.
What interventions are being tested in trial NCT06574009?
The interventions under investigation include: Multimodal pain care (BEHAVIORAL), Medication optimization (DRUG), Buprenorphine rotation (DEVICE), Opioid tapering (OTHER).
Who is sponsoring clinical trial NCT06574009?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06574009 being conducted?
This trial has 2 study locations across Indiana, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06574009's enrollment target sits among peer trials
294 55th of 301 higher than 247 of 301 other Chronic Pain trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Pain trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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