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ClinicalTrials.gov 65 recruiting now official registry

Chronic Lymphocytic Leukemia clinical trials

65 of 189 indexed Chronic Lymphocytic Leukemia trials are currently recruiting.

189 US clinical trials · 65 currently recruiting

Chronic Lymphocytic Leukemia is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 141 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 15 of these trials.

The research picture

Chronic Lymphocytic Leukemia has 189 registered US clinical trials, 65 of them open to new participants right now, about 34% of the total.

65
recruiting participants now
34%
of trials open to enrollment
27
in Phase 3–4 (later-stage)
15
top sponsor: M.D. Anderson Cancer Center
Phase 167Phase 274Phase 325Phase 42

Active & Recent Trials

189 total, page 2 of 4

RECRUITING Phase 2 40 participants

Phase II Study of Combined Pirtobrutinib, Venetoclax and Obinutuzumab (PVO) Time-limited Treatment for Patients With Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL).

M.D. Anderson Cancer Center

NCT06967610

RECRUITING Phase 1 40 participants

Mosunetuzumab for CLL MRD Clearance

Inhye Ahn

NCT07052695

RECRUITING Phase 2 34 participants

LP-168 and Obinutuzumab for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Variants of This

Zulfa Omer

NCT06978088

RECRUITING Phase 2 33 participants

Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

City of Hope Medical Center

NCT07218510

RECRUITING Phase 2 32 participants

Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma Subtype

Roswell Park Cancer Institute

NCT06863402

RECRUITING Phase 1 32 participants

Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

Vironexis Biotherapeutics

NCT06533579

RECRUITING Phase 2 30 participants

Local Manufacture of CAR T-Cell Products for the Treatment of B-Cell Lymphoma and B-Acute Lymphoblastic Leukemia

John Lister

NCT05281809

RECRUITING Phase 2 30 participants

Pirtobrutinib (LOXO-305) and Venetoclax for the Treatment of Patients With CLL or SLL Resistant to Covalent BTKi

Kerry Rogers

NCT06466122

RECRUITING Phase 1 27 participants

Metabolically Fit CD19 CAR T-cell Therapy With CD34 Selection in Patients With CD19+ Relapsed/Refractory NHL, CLL/SLL

Medical University of South Carolina

NCT05702853

RECRUITING Phase 1 27 participants

Tafasitamab, Acalabrutinib, and Obinutuzumab for the Treatment of Previously Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

OHSU Knight Cancer Institute

NCT05943496

RECRUITING Phase 2 27 participants

Acalabrutinib, Venetoclax and Durvalumab for the Treatment of Richter Transformation From Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Mayo Clinic

NCT05388006

RECRUITING Phase 2 22 participants

Study of Epcoritamab as a Consolidation Therapy in CLL/SLL

Zulfa Omer

NCT07108998

RECRUITING Phase 2 20 participants

Sonrotoclax, Rituximab, and Zanubrutinib in Treating Participants With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, and Mantle Cell Lymphoma

Fred Hutchinson Cancer Center

NCT06839053

RECRUITING Phase 2 20 participants

Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation

Weill Medical College of Cornell University

NCT04679012

RECRUITING 16 participants

In Vivo Metabolic Profiling of CLL (Chronic Lymphocytic Leukemia)

University of Wisconsin, Madison

NCT04785989

ACTIVE NOT RECRUITING 1,836 participants

Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer

National Cancer Institute (NCI)

NCT00039676

ACTIVE NOT RECRUITING Phase 3 984 participants

Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL

Acerta Pharma

NCT03836261

ACTIVE NOT RECRUITING Phase 3 720 participants

Assessing the Ability of Combination Treatment With Venetoclax to Permit Time Limited Therapy in Chronic Lymphocytic Leukemia

National Cancer Institute (NCI)

NCT03701282

ACTIVE NOT RECRUITING Phase 3 600 participants

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Loxo Oncology

NCT04965493

ACTIVE NOT RECRUITING Phase 3 590 participants

A Study Comparing Zanubrutinib With Bendamustine Plus Rituximab in Participants With Previously Untreated CLL or SLL

BeiGene

NCT03336333

ACTIVE NOT RECRUITING NA 565 participants

Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency

Mayo Clinic

NCT01787409

ACTIVE NOT RECRUITING Phase 3 535 participants

Acalabrutinib, Obinutuzumab and Chlorambucil in Treatment naïve CLL

Acerta Pharma

NCT02475681

ACTIVE NOT RECRUITING Phase 3 533 participants

Study of Acalabrutinib (ACP-196) Versus Ibrutinib in Previously Treated Participants With High Risk Chronic Lymphocytic Leukemia (CLL)

Acerta Pharma

NCT02477696

ACTIVE NOT RECRUITING Phase 3 529 participants

Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

National Cancer Institute (NCI)

NCT02048813

ACTIVE NOT RECRUITING Phase 3 465 participants

Testing the Addition of a New Anti-cancer Drug, Venetoclax, to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated, Older Patients With Chronic Lymphocytic Leukemia

National Cancer Institute (NCI)

NCT03737981

ACTIVE NOT RECRUITING NA 337 participants

Energy Balance Interventions in Increasing Physical Activity in Breast Cancer Gene Positive Patients, Lynch Syndrome-Positive Patients, CLL Survivors or High-Risk Family Members

M.D. Anderson Cancer Center

NCT02194387

ACTIVE NOT RECRUITING Phase 2 313 participants

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

Center for International Blood and Marrow Transplant Research

NCT06001385

ACTIVE NOT RECRUITING Phase 3 310 participants

A Study of Acalabrutinib vs Investigator's Choice of Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in R/R CLL

Acerta Pharma

NCT02970318

ACTIVE NOT RECRUITING Phase 3 309 participants

A Study of Pirtobrutinib (LOXO-305) Versus Bendamustine Plus Rituximab (BR) in Untreated Patients With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Loxo Oncology

NCT05023980

ACTIVE NOT RECRUITING Phase 1 306 participants

ACP-196 (Acalabrutinib), a Novel Bruton Tyrosine Kinase (BTK) Inhibitor, for Treatment of Chronic Lymphocytic Leukemia, Richter's Syndrome or Prolymphocytic Leukemia

Acerta Pharma

NCT02029443

ACTIVE NOT RECRUITING Phase 3 300 participants

A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)

Merck Sharp & Dohme

NCT05624554

ACTIVE NOT RECRUITING Phase 2 300 participants

HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Center for International Blood and Marrow Transplant Research

NCT04904588

ACTIVE NOT RECRUITING Phase 3 238 participants

Study of LOXO-305 (Pirtobrutinib) Versus Investigator's Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab) in Patients With Previously Treated Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Loxo Oncology

NCT04666038

ACTIVE NOT RECRUITING Phase 2 234 participants

Venetoclax and Ibrutinib in Treating Patients With Chronic or Small Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT02756897

ACTIVE NOT RECRUITING Phase 2 223 participants

A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)

Merck Sharp & Dohme

NCT05458297

ACTIVE NOT RECRUITING Phase 1 217 participants

Phase I/II Study of Rapcabtagene Autoleucel in CLL, 3L+ DLBCL, r/r ALL and 1L HR LBCL

Novartis Pharmaceuticals

NCT03960840

ACTIVE NOT RECRUITING Phase 1 190 participants

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT03162536

ACTIVE NOT RECRUITING Phase 3 165 participants

An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial

AbbVie

NCT03844048

ACTIVE NOT RECRUITING 150 participants

Biomarker for Infection Risk in CLL and MM

Massachusetts General Hospital

NCT05844033

ACTIVE NOT RECRUITING Phase 1 150 participants

NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers

Nkarta

NCT05020678

ACTIVE NOT RECRUITING Phase 2 120 participants

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Cellectar Biosciences

NCT02952508

ACTIVE NOT RECRUITING Phase 2 118 participants

A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-treatment Period

Genentech

NCT06524375

ACTIVE NOT RECRUITING Phase 2 102 participants

Multi-antigen CMV-MVA Triplex Vaccine in Reducing CMV Complications in Patients Previously Infected With CMV and Undergoing Donor Hematopoietic Cell Transplant

City of Hope Medical Center

NCT02506933

ACTIVE NOT RECRUITING Phase 2 94 participants

A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia

BeOne Medicines

NCT06637501

ACTIVE NOT RECRUITING Phase 1 87 participants

Bcl-2 Inhibitor GDC-0199 in Combination With Obinutuzumab and Ibrutinib in Treating Patients With Relapsed, Refractory, or Previously Untreated Chronic Lymphocytic Leukemia

Kerry Rogers

NCT02427451

ACTIVE NOT RECRUITING Phase 2 85 participants

A Phase II Study of Ibrutinib Plus FCR in Previously Untreated, Younger Patients With Chronic Lymphocytic Leukemia

Dana-Farber Cancer Institute

NCT02251548

ACTIVE NOT RECRUITING Phase 2 81 participants

Ibrutinib, Fludarabine Phosphate, Cyclophosphamide, and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT02629809

ACTIVE NOT RECRUITING Phase 2 72 participants

Pirtobrutinib and Venetoclax With MRD Detection for Previously Untreated Chronic Lymphocytic Leukemia

Mayo Clinic

NCT05677919

ACTIVE NOT RECRUITING Phase 1 72 participants

huCART19-IL18 in CD19+ Cancers

University of Pennsylvania

NCT04684563

ACTIVE NOT RECRUITING Phase 2 60 participants

A Study of ACP-196 (Acalabrutinib) in Subjects With Relapsed/Refractory CLL and Intolerant of Ibrutinib Therapy

Acerta Pharma

NCT02717611

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Phase Distribution

PhaseTrial count
Phase 1 67
Phase 2 74
Phase 3 25
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Lymphocytic Leukemia Trial Landscape

189 indexed Chronic Lymphocytic Leukemia studies · 65 recruiting (34%).

Phase mix: 27 late (III/IV) vs 141 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Lymphocytic Leukemia?

PlainTrial tracks 189 US clinical trials for Chronic Lymphocytic Leukemia, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Lymphocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.