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A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia
NCT06637501 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to support the registration plan of sonrotoclax plus zanubrutinib treatment in participants with previously untreated chronic lymphocytic leukemia (CLL). This study is designed to assess the contribution of sonrotoclax to the efficacy outcome of the combination of zanubrutinib and sonrotoclax.
Conditions Studied
Interventions
- DRUG Zanubrutinib
- DRUG Sonrotoclax
Study Locations (20)
Other
- Centro de Pesquisas Oncologicas Cepon — Florianópolis
- Hospital de Clinicas de Porto Alegre — Porto AlegreRS
- Instituto Dor de Pesquisa E Ensino Sao Paulo — São Paulo
- Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein — São Paulo
Nebraska
- Nebraska Cancer Specialists (Satellite Site) — Omaha
- Nebraska Cancer Specialists — Omaha
- University of Nebraska Medical Center — Omaha
Texas
- Texas Oncology Dfw — Dallas
- Texas Oncology Tyler — Tyler
Jiangsu
- The First Peoples Hospital of Changzhou — Changzhou
- Jiangsu Province Hospital — Nanjing
Florida
- Cleveland Clinic Florida — Weston
Georgia
- Northwest Georgia Oncology Centers Marietta — Marietta
Illinois
- Illinois Cancer Specialists (Niles) Usor — Niles
Maryland
- University of Maryland Greenebaum Comprehensive Cancer Center — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 94 participants |
| Start Date | 2024-11-14 |
| Est. Completion | 2029-09 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06637501
The ClinicalTrials.gov registry entry for NCT06637501 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 94 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 2 interventions — of which Zanubrutinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06637501 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, Nebraska, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06637501 about?
NCT06637501 is a clinical study titled "A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia". The purpose of this study is to support the registration plan of sonrotoclax plus zanubrutinib treatment in participants with previously untreated chronic lymphocytic leukemia (CLL). This study is designed to assess the contribution of sonrotoclax to the efficacy outcome of the combination of zanubr...
What is the current status of trial NCT06637501?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 94 participants. The study started on 2024-11-14. Estimated completion is 2029-09.
What conditions does trial NCT06637501 study?
This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06637501?
The interventions under investigation include: Zanubrutinib (DRUG), Sonrotoclax (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06637501?
This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06637501 being conducted?
This trial has 20 study locations across Florida, Georgia, Illinois, Maryland, Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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