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ClinicalTrials.gov 65 recruiting now official registry

Chronic Lymphocytic Leukemia clinical trials

65 of 189 indexed Chronic Lymphocytic Leukemia trials are currently recruiting.

189 US clinical trials · 65 currently recruiting

Chronic Lymphocytic Leukemia is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 141 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 15 of these trials.

The research picture

Chronic Lymphocytic Leukemia has 189 registered US clinical trials, 65 of them open to new participants right now, about 34% of the total.

65
recruiting participants now
34%
of trials open to enrollment
27
in Phase 3–4 (later-stage)
15
top sponsor: M.D. Anderson Cancer Center
Phase 167Phase 274Phase 325Phase 42

Active & Recent Trials

189 total, page 1 of 4

RECRUITING 2,750 participants

Understanding Chronic Lymphocytic Leukemia

Dana-Farber Cancer Institute

NCT04028531

RECRUITING 2,000 participants

The Prospective Collection, Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen

Wake Forest University Health Sciences

NCT01890486

RECRUITING 2,000 participants

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

Alliance for Clinical Trials in Oncology

NCT05334069

RECRUITING Phase 3 1,200 participants

A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)

Merck Sharp & Dohme

NCT06136559

RECRUITING Phase 4 787 participants

A Master Protocol to Evaluate the Long-Term Safety of (LY3527727) Pirtobrutinib

Eli Lilly and Company

NCT06876649

RECRUITING Phase 3 700 participants

A Long-term Extension Study of PCI-32765 (Ibrutinib)

Janssen Research & Development

NCT01804686

RECRUITING Phase 3 662 participants

A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Loxo Oncology

NCT05254743

RECRUITING Phase 3 630 participants

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

BeOne Medicines

NCT06943872

RECRUITING Phase 1 614 participants

A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

BeOne Medicines

NCT05006716

RECRUITING Phase 3 500 participants

A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

BeOne Medicines

NCT06973187

RECRUITING 500 participants

Long-term Follow-up Study of Patients Receiving CAR-T Cells

Medical College of Wisconsin

NCT03375619

RECRUITING Phase 4 279 participants

A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

Eli Lilly and Company

NCT06876662

RECRUITING Phase 3 250 participants

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

BeOne Medicines

NCT06846671

RECRUITING Phase 2 249 participants

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Loxo Oncology

NCT06588478

RECRUITING Phase 3 247 participants

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

National Cancer Institute (NCI)

NCT04269902

RECRUITING Phase 2 216 participants

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

City of Hope Medical Center

NCT06059391

RECRUITING 200 participants

Evaluation of Human Immune Responses Vaccination in Patients With Lymphoma

Emory University

NCT03501576

RECRUITING NA 200 participants

Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for Hematological Diseases

Masonic Cancer Center, University of Minnesota

NCT01962636

RECRUITING Phase 3 170 participants

A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

AbbVie

NCT06428019

RECRUITING Phase 1 154 participants

A Study to Assess the Adverse Events, Change in Disease Activity, and How Intravenously Infused ABBV-319 Moves Through the Bodies of Adult Participants With Relapsed or Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), or Chronic Lymphocytic Leukemia (CLL)

AbbVie

NCT05512390

RECRUITING Phase 1 150 participants

Study to Evaluate Adverse Events and Change in Disease Activity in Adult Participants With B-Cell Malignancies Receiving Oral ABBV-525 Tablets

AbbVie

NCT05618028

RECRUITING Phase 1 137 participants

A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia

Hoffmann-La Roche

NCT05091424

RECRUITING Phase 1 135 participants

Dose-escalation and Dose-expansion Study of Safety of Azer-cel (PBCAR0191) in Participants With Relapsed/Refractory (r/r) Non-Hodgkin Lymphoma (NHL) and r/r B-cell Acute Lymphoblastic Leukemia (B-ALL)

Imugene Limited

NCT03666000

RECRUITING Phase 2 120 participants

Acalabrutinib With or Without Obinutuzumab in Treating Patients With Early-Stage Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Mayo Clinic

NCT03516617

RECRUITING Phase 1 120 participants

AS-1763 in Patients With Previously Treated CLL/SLL or Non-Hodgkin Lymphoma

Carna Biosciences

NCT05602363

RECRUITING Phase 2 108 participants

A Study of Emavusertib + An Approved Bruton Tyrosine Kinase Inhibitor (BTKi) in Participants With Chronic Lymphocytic Leukemia (CLL) and Other B-cell Malignancies

Curis

NCT07271667

RECRUITING Phase 2 100 participants

A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

VA Office of Research and Development

NCT06520098

RECRUITING Phase 1 100 participants

Study of Oral Administration of LP-118 in Patients With Relapsed or Refractory CLL, SLL, MDS, MDS/MPN, AML, CMML-2, MPN-BP, ALL, MF, NHL, RT, MM or T-PLL.

Newave Pharmaceutical

NCT04771572

RECRUITING 100 participants

Evaluation of Hypertension Management and Cardiovascular Adverse Event Prevention in Patients With B-cell Malignancies Undergoing Treatment With Bruton Tyrosine Kinase Inhibitors, the HALT Study

Mayo Clinic

NCT06151730

RECRUITING Phase 2 90 participants

Venetoclax With Ibrutinib or Acalabrutinib in Pts. With High-risk CLL

M.D. Anderson Cancer Center

NCT03128879

RECRUITING Phase 2 86 participants

Effects of Nicotinamide in Patients With Chronic Lymphocytic Leukemia With History of Non-melanoma Skin Cancers

University of Utah

NCT04844528

RECRUITING Phase 2 80 participants

Anti-pneumococcal Vaccine Strategy in Patients With Chronic Lymphocytic Leukemia

Seema Bhat

NCT05417165

RECRUITING Phase 2 80 participants

A Vaccine Booster (GEO-CM04S1) for the Prevention of COVID-19 in Patients With Chronic Lymphocytic Leukemia

City of Hope Medical Center

NCT05672355

RECRUITING Phase 2 75 participants

Early Clonal Dynamics During Venetoclax Treatment for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)

National Heart, Lung, and Blood Institute (NHLBI)

NCT03986034

RECRUITING Phase 2 70 participants

Phase 2 Study of Glofitamab Monotherapy & With Polatuzumab Vedotin, Pirtobrutinib, or Atezolizumab in Richter's Transformation

Christine Ryan

NCT06043674

RECRUITING Phase 1 64 participants

Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN)

Baylor College of Medicine

NCT01853631

RECRUITING Phase 1 64 participants

Roginolisib (IOA-244) With Venetoclax and Rituximab for Refractory/Relapsed Chronic Lymphocytic Leukemia (CLL)

Jennifer R. Brown, MD, PhD

NCT06644183

RECRUITING Phase 2 63 participants

Two Step Haplo With Radiation Conditioning

Thomas Jefferson University

NCT05031897

RECRUITING Phase 2 62 participants

Intermittent Versus Continuous Venetoclax With Acalabrutinib for CLL/SLL

Zulfa Omer

NCT07014917

RECRUITING Phase 2 60 participants

Pneumococcal Pneumonia Vaccine Series (PCV20 and PPSV23) in Patients With Chronic Lymphocytic Leukemia Associated Immunodeficiency, PROTECT CLL Trial

University of Utah

NCT05183854

RECRUITING Phase 2 60 participants

Fixed Duration Pirtobrutinib and Obinutuzumab in Chronic Lymphocytic Leukemia

Inhye Ahn

NCT06333262

RECRUITING Phase 2 60 participants

Acalabrutinib and Obinutuzumab for the Treatment of Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT04505254

RECRUITING Phase 2 52 participants

Acalabrutinib in Combination With Venetoclax or Obinutuzumab for the Treatment of Treatment-naive Chronic Lymphocytic Leukemia

Ohio State University Comprehensive Cancer Center

NCT05336812

RECRUITING NA 50 participants

Implanted Loop Recorders for Detection and Management of Arrhythmia With Bruton Tyrosine Kinase Inhibitors

Northwell Health

NCT05643235

RECRUITING 50 participants

Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects

Mayo Clinic

NCT06536452

RECRUITING 45 participants

Vaccine Responses in Patient With Multiple Myeloma and Non-Hodgkin Lymphoma After CAR-T Treatment

OHSU Knight Cancer Institute

NCT06784167

RECRUITING Early Phase 1 42 participants

64Cu-LLP2A for Imaging Hematologic Malignancies

Washington University School of Medicine

NCT06636175

RECRUITING NA 40 participants

Combating Cancer-Related Fatigue: A Personalized Supportive Care Program

UNC Lineberger Comprehensive Cancer Center

NCT06860880

RECRUITING Phase 2 40 participants

Venetoclax-Obinutuzumab +/- Acalabrutinib in R/R CLL

Massachusetts General Hospital

NCT04560322

RECRUITING Phase 2 40 participants

Zanubrutinib, Obinutuzumab, and Sonrotoclax in Previously Untreated Patients With CLL or SLL

Massachusetts General Hospital

NCT06849713

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Phase Distribution

PhaseTrial count
Phase 1 67
Phase 2 74
Phase 3 25
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Lymphocytic Leukemia Trial Landscape

189 indexed Chronic Lymphocytic Leukemia studies · 65 recruiting (34%).

Phase mix: 27 late (III/IV) vs 141 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Lymphocytic Leukemia?

PlainTrial tracks 189 US clinical trials for Chronic Lymphocytic Leukemia, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Lymphocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.