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ACTIVE NOT RECRUITING Phase 2

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

NCT02952508 · View on ClinicalTrials.gov ↗

Study Summary

Part A of this study evaluates iopofosine I 131 (CLR 131) in patients with select B-cell malignancies (multiple myeloma( MM), indolent chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), lymphoplasmacytic lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), marginal zone lymphoma (MZL), mantle cell lymphoma (MCL), diffuse large B-cell lymphoma (DLBCL), and central nervous system lymphoma (CNSL) who have been previously treated with standard therapy for their underlying malignancy. Part B (CLOVER-WaM) is a pivotal efficacy study evaluating IV administration of iopofosine I 131 in patients with WM that have received at least two prior lines of therapy.

Interventions

  • DRUG Iopofosine I 131 single dose
  • DRUG Iopofosine I 131 multiple dose
  • DRUG Iopofosine I 131 fractionated dose

Study Locations (20)

Florida

  • Cellectar Biosciences site — Jacksonville
  • Cellectar Biosciences site — Miami
  • Cellectar Biosciences site — Tampa

New York

  • Cellectar Biosciences site — Buffalo
  • Cellectar Biosciences site — New York
  • Cellectar Biosciences site — Rochester

California

  • Cellectar Biosciences site — Los Angeles
  • Cellectar Biosciences site — Redlands

Illinois

  • Cellectar Biosciences site — Maywood
  • Cellectar Biosciences site — Warrenville

Maryland

  • Cellectar Biosciences site — Baltimore
  • Cellectar Biosciences — Bethesda

District of Columbia

  • Cellectar Biosciences site — Washington D.C.

Georgia

  • Cellectar Biosciences — Atlanta

Kansas

  • Cellectar Biosciences site — Westwood

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2017-07-26
Est. Completion 2027-12-22
Phase Phase 2

Sponsor

Cellectar Biosciences

6 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02952508

The ClinicalTrials.gov registry entry for NCT02952508 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Cellectar Biosciences, which has 6 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 9 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 3 interventions — of which Iopofosine I 131 single dose is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02952508 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Florida, New York, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02952508 about?

NCT02952508 is a clinical study titled "Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom". Part A of this study evaluates iopofosine I 131 (CLR 131) in patients with select B-cell malignancies (multiple myeloma( MM), indolent chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), lymphoplasmacytic lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), marginal zone lymphoma (MZL...

What is the current status of trial NCT02952508?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 120 participants. The study started on 2017-07-26. Estimated completion is 2027-12-22.

What conditions does trial NCT02952508 study?

This clinical trial studies the following conditions: Multiple Myeloma, Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Small Lymphocytic Lymphoma, Marginal Zone Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02952508?

The interventions under investigation include: Iopofosine I 131 single dose (DRUG), Iopofosine I 131 multiple dose (DRUG), Iopofosine I 131 fractionated dose (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02952508?

This trial is sponsored by Cellectar Biosciences, which has 6 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02952508 being conducted?

This trial has 20 study locations across California, District of Columbia, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial