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NCT06524375 · ClinicalTrials.gov registry record · Phase 2
A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-treatment Period
A Phase 2 study of Chronic Lymphocytic Leukemia, sponsored by Genentech.
- Active
- Registry status
- Phase 2
- Development phase
- 118
- Enrollment target
- 20
- Study locations
NCT06524375: Active Phase 2 study of Chronic Lymphocytic Leukemia, sponsored by Genentech.
NCT06524375 is a Phase 2 study of Chronic Lymphocytic Leukemia that is active but no longer recruiting, run by Genentech. The registered enrollment target is 118 participants, below the 181-participant average among 187 other Chronic Lymphocytic Leukemia trials with a reported enrollment target (35% lower). The trial reports 20 study locations across 15 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06524375, a Phase 2 study of Chronic Lymphocytic Leukemia, is active but no longer recruiting, sponsored by Genentech.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 118 participants
- Enrollment target
- 20
- Study locations
Study Summary
The main purpose of the study is to evaluate if adding venetoclax to participants receiving cBTKi for the 1L CLL can achieve deep durable remissions of undetectable measurable residual disease \[uMRD \< or 10\^-4 in peripheral blood (PB)\] by end of combination treatment (EOCT) to allow off-treatment period. The acronym BRAVE stands for Btki Responders to Achieve deep remission (or off-treatment periods) with VEnetoclax.
Primary Outcome
uMRD4 will be assessed using next generation sequencing (NGS) (sensitivity 10\^-4) from PB.
Conditions Studied
Interventions
- DRUG Venetoclax
- DRUG cBTKi Monotherapy
Study Locations (20)
Nebraska
- Nebraska Cancer Specialists St Francis - Grand Island - Grand Island
- Nebraska Cancer Specialists - Omaha
Ohio
- Oncology Hematology Care Inc - Cincinnati - USOR - Cincinnati
- Ohio State University - Columbus
Oregon
- Willamette Valley Cancer Institute and Research Center - Eugene
- Asante Rogue Regional Medical Center - Medford
Tennessee
- Tennessee Oncology, PLLC - Chattanooga - Chattanooga
- Tennessee Oncology - Midtown - Nashville
Texas
- MD Anderson Cancer Center - Houston
- Texas Oncology- Northeast Texas - Tyler
Arkansas
- Highlands Oncology Group - Springdale
Colorado
- Rocky Mountain Cancer Centers (Aurora) - USOR - Aurora
Florida
- Cancer Specialists of North Florida - Jacksonville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 118 participants |
| Start Date | 2024-08-09 |
| Est. Completion | 2030-01-31 |
| Phase | Phase 2 |
What the registry record for NCT06524375 still lists
NCT06524375 is an interventional study that assigns participants to a tested intervention. The registered 118 participants enrollment target is mid-sized for trials with a published cap, below the 181-participant average among 187 other Chronic Lymphocytic Leukemia trials with a reported enrollment target (35% lower).
The record links to 1 condition, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 2 interventions - of which Venetoclax is the first listed.
NCT06524375 names 20 study sites across 15 states, led by Nebraska, Ohio, Oregon.
Frequently Asked Questions
What is clinical trial NCT06524375 about?
NCT06524375 is a clinical study titled "A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-treatment Period". The main purpose of the study is to evaluate if adding venetoclax to participants receiving cBTKi for the 1L CLL can achieve deep durable remissions of undetectable measurable residual disease \[uMRD \< or 10\^-4 in peripheral blood (PB)\] by end of combination treatment (EOCT) to allow off-treatmen...
What is the current status of trial NCT06524375?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 118 participants. The study started on 2024-08-09. Estimated completion is 2030-01-31.
What conditions does trial NCT06524375 study?
This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia.
What interventions are being tested in trial NCT06524375?
The interventions under investigation include: Venetoclax (DRUG), cBTKi Monotherapy (DRUG).
Who is sponsoring clinical trial NCT06524375?
This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06524375 being conducted?
This trial has 20 study locations across Arkansas, Colorado, Florida, Indiana, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Chronic Lymphocytic Leukemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06524375's enrollment target sits among peer trials
118 59th of 187 higher than 129 of 187 other Chronic Lymphocytic Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Chronic Lymphocytic Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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