Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 65 recruiting now official registry

Chronic Lymphocytic Leukemia clinical trials

65 of 189 indexed Chronic Lymphocytic Leukemia trials are currently recruiting.

189 US clinical trials · 65 currently recruiting

Chronic Lymphocytic Leukemia is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 65 of them currently open to new participants. 27 are in Phase 3-4 (later-stage) and 141 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 15 of these trials.

The research picture

Chronic Lymphocytic Leukemia has 189 registered US clinical trials, 65 of them open to new participants right now, about 34% of the total.

65
recruiting participants now
34%
of trials open to enrollment
27
in Phase 3–4 (later-stage)
15
top sponsor: M.D. Anderson Cancer Center
Phase 167Phase 274Phase 325Phase 42

Active & Recent Trials

189 total, page 3 of 4

ACTIVE NOT RECRUITING Phase 1 58 participants

Trial of Anti-CD19 and Anti-CD20 Bicistronic Chimeric Antigen Receptor T Cells for Treating B-Cell Malignancies

National Cancer Institute (NCI)

NCT05797233

ACTIVE NOT RECRUITING Phase 1 56 participants

A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.

BeiGene

NCT06697184

ACTIVE NOT RECRUITING Phase 2 55 participants

A Study on Limiting Treatment Time With Acalabrutinib Combined With Obinutuzumab in People With CLL or SLL

Memorial Sloan Kettering Cancer Center

NCT04722172

ACTIVE NOT RECRUITING Phase 1 55 participants

Duvelisib and Venetoclax in Relapsed or Refractory CLL or SLL or RS

Dana-Farber Cancer Institute

NCT03534323

ACTIVE NOT RECRUITING Phase 1 54 participants

A Study of Ibrutinib + Obinutuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

Dana-Farber Cancer Institute

NCT02537613

ACTIVE NOT RECRUITING Phase 1 54 participants

FT819 in Subjects With B-cell Malignancies

Fate Therapeutics

NCT04629729

ACTIVE NOT RECRUITING Phase 2 50 participants

Atezolizumab, Obinutuzumab, and Venetoclax in Treating Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Relapsed or Refractory Richter Syndrome

M.D. Anderson Cancer Center

NCT02846623

ACTIVE NOT RECRUITING Phase 2 49 participants

Lenalidomide and Vaccine Therapy in Treating Patients With Early-Stage Asymptomatic Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

National Cancer Institute (NCI)

NCT01351896

ACTIVE NOT RECRUITING Phase 2 42 participants

Ibrutinib as an Immune Modulating Agent for Patients With Asymptomatic, High-risk CLL/SLL Risk Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Jennifer Woyach

NCT02518555

ACTIVE NOT RECRUITING Phase 1 40 participants

Safe Accelerated Venetoclax Escalation in CLL

Dana-Farber Cancer Institute

NCT04843904

ACTIVE NOT RECRUITING Phase 1 34 participants

CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant

City of Hope Medical Center

NCT03560752

ACTIVE NOT RECRUITING Phase 2 33 participants

Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

University of Washington

NCT02339922

ACTIVE NOT RECRUITING Phase 1 32 participants

A Phase 1b/2 Study of IPI-145 Plus FCR in Previously Untreated, Younger Patients With CLL

Dana-Farber Cancer Institute

NCT02158091

ACTIVE NOT RECRUITING NA 30 participants

HEALTH4CLL2: A Randomized Waitlist Control Trial of Behavioral Interventions in Patients With Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT05879133

ACTIVE NOT RECRUITING NA 30 participants

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Ohio State University Comprehensive Cancer Center

NCT05972577

ACTIVE NOT RECRUITING Phase 1 30 participants

19(T2)28z1xx Chimeric Antigen Receptor (CAR) T Cells in People With B-Cell Cancers

Memorial Sloan Kettering Cancer Center

NCT04464200

ACTIVE NOT RECRUITING Phase 2 29 participants

A Phase II Study Using Ibrutinib and Short-Course Fludarabine in Treatment-Naive CLL

National Heart, Lung, and Blood Institute (NHLBI)

NCT02514083

ACTIVE NOT RECRUITING Phase 2 29 participants

Acalabrutinib, Umbralisib, and Ublituximab (AU2) In Relapsed and Untreated CLL

Jennifer R. Brown, MD, PhD

NCT04624633

ACTIVE NOT RECRUITING Phase 2 28 participants

Venetoclax and Ibrutinib in Treating in Participants With Chronic Lymphocytic Leukemia and Ibrutinib Resistance Mutations

Ohio State University Comprehensive Cancer Center

NCT03513562

ACTIVE NOT RECRUITING Phase 1 27 participants

Copanlisib and Nivolumab in Treating Patients With Richter's Transformation or Transformed Indolent Non-Hodgkin Lymphoma

City of Hope Medical Center

NCT03884998

ACTIVE NOT RECRUITING Phase 2 26 participants

Tafasitamab and Zanubrutinib for the Treatment of Patients With Newly Diagnosed Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, TaZA CLL Study

City of Hope Medical Center

NCT05718869

ACTIVE NOT RECRUITING Phase 2 25 participants

A Study of Venetoclax and Rituximab/Hyaluronidase Human in Relapsed/Refractory CLL

Georgetown University

NCT03467867

ACTIVE NOT RECRUITING Phase 1 24 participants

Addition of Loncastuximab Tesirine to Acalbrutinib , Chronic Lymphocytic Leukemia

University of Alabama at Birmingham

NCT05971251

ACTIVE NOT RECRUITING Phase 1 24 participants

Venetoclax With High-dose Ibrutinib for CLL Progressing on Single Agent Ibrutinib

Michael Choi

NCT03422393

ACTIVE NOT RECRUITING Phase 1 23 participants

Study to Evaluate the Safety and Preliminary Efficacy of Ibrutinib and Pembrolizumab in Patients With Chronic Lymphocytic Leukemia (CLL) or Mantle Cell Lymphoma (MCL)

Joshua Brody

NCT03153202

ACTIVE NOT RECRUITING Phase 3 21 participants

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Dartmouth-Hitchcock Medical Center

NCT03480360

ACTIVE NOT RECRUITING Phase 1 18 participants

Human AntiCD19 Chimeric Antigen Receptor T Cells for Relapsed or Refractory Lymphoid Malignancies

Benjamin Tomlinson

NCT04732845

ACTIVE NOT RECRUITING Phase 1 16 participants

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03622788

ACTIVE NOT RECRUITING Phase 1 16 participants

Study Evaluating SC291 in Subjects With r/r B-cell Malignancies (ARDENT)

Sana Biotechnology

NCT05878184

ACTIVE NOT RECRUITING Phase 1 15 participants

Daratumumab and Ibrutinib in Treating Patients With Symptomatic Chronic Lymphocytic Leukemia

Jennifer Woyach

NCT03447808

ACTIVE NOT RECRUITING Phase 1 14 participants

CD19 Chimeric Receptor Expressing T Lymphocytes In B-Cell Non Hodgkin's Lymphoma, ALL & CLL

Baylor College of Medicine

NCT00586391

ACTIVE NOT RECRUITING Phase 1 12 participants

Acalabrutinib in Combination With ACP-319, for Treatment of Chronic Lymphocytic Leukemia

Acerta Pharma

NCT02157324

ACTIVE NOT RECRUITING Phase 2 10 participants

Ruxolitinib Phosphate in Reducing Fatigue in Patients With Chronic Lymphocytic Leukemia

M.D. Anderson Cancer Center

NCT02131584

ACTIVE NOT RECRUITING Phase 2 7 participants

Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

City of Hope Medical Center

NCT04060277

ACTIVE NOT RECRUITING Phase 2 5 participants

Cirmtuzumab Consolidation for Treatment of Patients With Detectable CLL on Venetoclax

University of California, San Diego

NCT04501939

ACTIVE NOT RECRUITING Phase 2 4 participants

Acalabrutinib for the Treatment of Relapsed or Refractory Autoimmune Hemolytic Anemia in Patients With Chronic Lymphocytic Leukemia

City of Hope Medical Center

NCT04657094

ACTIVE NOT RECRUITING Phase 1 4 participants

A Study Assessing Adverse Event and How Oral ABBV-453 Moves Through the Body in Adult Participants With Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

AbbVie

NCT06291220

COMPLETED Phase 3 652 participants

A Study of Zanubrutinib (BGB-3111) Versus Ibrutinib in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia

BeiGene

NCT03734016

COMPLETED Phase 3 552 participants

Acalabrutinib Safety Study in Untreated and Relapsed or Refractory Chronic Lymphocytic Leukemia Patients

AstraZeneca

NCT04008706

COMPLETED Phase 2 279 participants

Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)

National Heart, Lung, and Blood Institute (NHLBI)

NCT02208037

COMPLETED Phase 1 222 participants

A Phase 1 Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma

AbbVie

NCT01328626

COMPLETED Phase 3 220 participants

A Randomized, Double-Blind, Placebo-Controlled Study of Idelalisib in Combination With Rituximab for Previously Treated Chronic Lymphocytic Leukemia (CLL)

Gilead Sciences

NCT01539512

COMPLETED Phase 1 160 participants

Ublituximab in Combination With TGR-1202 +/- Ibrutinib or Bendamustine in Patients With B-cell Malignancies

TG Therapeutics

NCT02006485

COMPLETED Phase 1 154 participants

Study to Evaluate Safety and Tolerability of XmAb13676 (Plamotamab) in Patients With CD20-expressing Hematologic Malignancies

Xencor

NCT02924402

COMPLETED Phase 2 102 participants

The Role of Cyclosporine in Blood Cell Transplants With T-Cell Add-Back for Blood Cancers

National Heart, Lung, and Blood Institute (NHLBI)

NCT00001873

COMPLETED Phase 1 96 participants

First in Human Study to Determine the Safety, Tolerability and Preliminary Efficacy of an Anti-CXCR4 Antibody in Subjects With Acute Myelogenous Leukemia and Selected B-cell Cancers

Bristol-Myers Squibb

NCT01120457

COMPLETED Phase 1 91 participants

A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)

VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT03833180

COMPLETED Phase 2 77 participants

Ofatumumab for Patients With Previously Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

SCRI Development Innovations

NCT01113632

COMPLETED Phase 1 70 participants

Safety and Efficacy of IDEC-152 in the Treatment of Chronic Lymphocytic Leukemia (CLL)

Biogen

NCT00046488

COMPLETED Phase 1 66 participants

Ublituximab + Ibrutinib in Select B-cell Malignancies

TG Therapeutics

NCT02013128

← Previous Page 3 of 4 Next →

Phase Distribution

PhaseTrial count
Phase 1 67
Phase 2 74
Phase 3 25
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Lymphocytic Leukemia Trial Landscape

189 indexed Chronic Lymphocytic Leukemia studies · 65 recruiting (34%).

Phase mix: 27 late (III/IV) vs 141 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (15 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Lymphocytic Leukemia?

PlainTrial tracks 189 US clinical trials for Chronic Lymphocytic Leukemia, of which 65 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Lymphocytic Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.