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A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
NCT06943872 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
Conditions Studied
Interventions
- DRUG Obinutuzumab
- DRUG Venetoclax
- DRUG Sonrotoclax
- DRUG Rituximab
Study Locations (20)
California
- Uci Health Laguna Hills — Laguna Hills
- Chao Family Comprehensive Cancer Center — Orange
- Stanford Cancer Institute — Palo Alto
- Scripps Prebys Cancer Center — San Diego
Connecticut
- Yale University, Yale Cancer Center — New Haven
- Eastern Connecticut Hematology and Oncology — Norwich
Illinois
- Northwestern University — Chicago
- Illinois Cancer Specialists (Niles) Usor — Niles
New York
- Memorial Sloan Kettering Cancer Center Mskcc — New York
- Clinical Research Alliance, Inc — Westbury
North Carolina
- University of North Carolina At Chapel Hill — Chapel Hill
- Levine Cancer Center — Charlotte
Colorado
- Rocky Mountain Cancer Centers (Williams) Usor — Aurora
Kentucky
- University of Louisville, Brown Cancer Center — Louisville
Louisiana
- Mary Bird Perkins Cancer Center — Baton Rouge
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 630 participants |
| Start Date | 2025-06-11 |
| Est. Completion | 2031-12 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06943872
The ClinicalTrials.gov registry entry for NCT06943872 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 630 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 4 interventions — of which Obinutuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06943872 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Connecticut, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06943872 about?
NCT06943872 is a clinical study titled "A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)". The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituxim...
What is the current status of trial NCT06943872?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 630 participants. The study started on 2025-06-11. Estimated completion is 2031-12.
What conditions does trial NCT06943872 study?
This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06943872?
The interventions under investigation include: Obinutuzumab (DRUG), Venetoclax (DRUG), Sonrotoclax (DRUG), Rituximab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06943872?
This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06943872 being conducted?
This trial has 20 study locations across California, Colorado, Connecticut, Illinois, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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