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RECRUITING Phase 4

A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma

NCT06876662 · View on ClinicalTrials.gov ↗

Study Summary

Study J2N-MC-JZ01 (JZ01) is an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator study, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator study will have the opportunity to continue their assigned study intervention or continue their follow-up visits by transitioning to this study. This study will evaluate the long-term safety and efficacy of pirtobrutinib.

Interventions

  • DRUG Pirtobrutinib

Study Locations (20)

New York

  • Cayuga Cancer Center — Ithaca
  • Northwell Health — Lake Success
  • Memorial Sloan-Kettering Cancer Center (MSKCC) - New York — New York
  • Memorial Sloan-Kettering Cancer Center (MSKCC) - New York — New York

Florida

  • Sylvester Comprehensive Cancer Center — Miami
  • Florida Cancer Specialists — Sarasota

Other

  • Flinders Medical Centre — Adelaide
  • Peter MacCallum Cancer Centre — Melbourne

Georgia

  • The Emory Clinic — Atlanta

Illinois

  • Northwestern University — Chicago

Massachusetts

  • Dana-Farber Cancer Institute — Boston

Minnesota

  • Mayo Clinic- Minnesota — Rochester

Nebraska

  • University Of Nebraska Medical Center — Omaha

Trial Details

FieldValue
Enrollment Target 279 participants
Start Date 2025-05-20
Est. Completion 2032-12
Phase Phase 4

Sponsor

Eli Lilly and Company

704 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06876662

The ClinicalTrials.gov registry entry for NCT06876662 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 279 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 1 intervention — of which Pirtobrutinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06876662 reports 20 study locations spanning 15 distinct geographic areas — top geographies include New York, Florida, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06876662 about?

NCT06876662 is a clinical study titled "A Study of (LY3527727) Pirtobrutinib in Participants With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Non-Hodgkin Lymphoma". Study J2N-MC-JZ01 (JZ01) is an individual-study appendix (ISA) under master protocol J2N-MC-JZNY, and represents participants from the completed originator study, clinical study LOXO-BTK-18001/J2N-OX-JZNA. Participants in the originator study will have the opportunity to continue their assigned stud...

What is the current status of trial NCT06876662?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 279 participants. The study started on 2025-05-20. Estimated completion is 2032-12.

What conditions does trial NCT06876662 study?

This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06876662?

The interventions under investigation include: Pirtobrutinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06876662?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06876662 being conducted?

This trial has 20 study locations across Florida, Georgia, Illinois, Massachusetts, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial