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RECRUITING Phase 3

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

NCT06846671 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to investigate the efficacy and safety of BGB-16673 compared with investigator's choice (idelalisib plus rituximab \[for CLL only\] or bendamustine plus rituximab or venetoclax plus rituximab retreatment) in participants with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) previously exposed to both BTK inhibitors (BTKi) and BCL2 inhibitors (BCL2i).

Interventions

  • DRUG Venetoclax
  • DRUG BGB-16673
  • DRUG Rituximab
  • DRUG Bendamustine
  • DRUG Idelalisib

Study Locations (20)

Florida

  • Florida Oncology and Hematology — Fort Myers
  • Baptist Md Anderson Cancer Center — Jacksonville
  • Cleveland Clinic Florida — Weston

California

  • UCLA Department of Medicine Hematologyoncology — Los Angeles
  • Pih Health Whittier Hospital — Whittier

New York

  • Memorial Sloan Kettering Cancer Center Mskcc — New York
  • Clinical Research Alliance, Inc — Westbury

Ohio

  • University Hospitals — Cleveland
  • Dayton Physician Network — Dayton

Pennsylvania

  • West Penn Hospital — Pittsburgh
  • Cancer Care Associates of York — York

Arkansas

  • St Bernards Medical Center — Jonesboro

Colorado

  • Rocky Mountain Cancer Centers (Williams) Usor — Aurora

Georgia

  • Emory University Winship Cancer Institute — Atlanta

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2025-04-10
Est. Completion 2030-02-14
Phase Phase 3

Sponsor

BeOne Medicines

138 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06846671

The ClinicalTrials.gov registry entry for NCT06846671 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Venetoclax is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06846671 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, California, New York. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06846671 about?

NCT06846671 is a clinical study titled "A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors". The purpose of this study is to investigate the efficacy and safety of BGB-16673 compared with investigator's choice (idelalisib plus rituximab \[for CLL only\] or bendamustine plus rituximab or venetoclax plus rituximab retreatment) in participants with chronic lymphocytic leukemia (CLL) or small l...

What is the current status of trial NCT06846671?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 250 participants. The study started on 2025-04-10. Estimated completion is 2030-02-14.

What conditions does trial NCT06846671 study?

This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia, CLL. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06846671?

The interventions under investigation include: Venetoclax (DRUG), BGB-16673 (DRUG), Rituximab (DRUG), Bendamustine (DRUG), Idelalisib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06846671?

This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06846671 being conducted?

This trial has 20 study locations across Arkansas, California, Colorado, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial