Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

NCT06973187 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the efficacy and safety of BGB-16673 alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had been previously treated with a covalent Bruton tyrosine kinase inhibitor (cBTKi).

Interventions

  • DRUG BGB-16673
  • DRUG Pirtobrutinib

Study Locations (20)

California

  • University of California San Diego (Ucsd) Moores Cancer Center — La Jolla
  • UCLA Department of Medicine Hematologyoncology — Los Angeles
  • Stanford Cancer Institute — Palo Alto

Florida

  • Cancer Specialists of North Florida — Jacksonville
  • Mayo Clinic Jacksonville — Jacksonville
  • Mount Sinai Comprehensive Cancer Center — Miami Beach

Louisiana

  • Our Lady of the Lake Hospital — Baton Rouge
  • Mary Bird Perkins Cancer Center — Baton Rouge
  • Ochsner Clinic Foundation — New Orleans

New York

  • Memorial Sloan Kettering Cancer Center Mskcc — New York
  • University of Rochester — Rochester

Arizona

  • Mayo Clinic Phoenix — Phoenix

Delaware

  • Christiana Care — Newark

Kansas

  • The University of Kansas Cancer Center — Westwood

Massachusetts

  • Dana Farber Cancer Institute — Boston

Trial Details

FieldValue
Enrollment Target 500 participants
Start Date 2025-09-04
Est. Completion 2028-04-17
Phase Phase 3

Sponsor

BeOne Medicines

138 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06973187

The ClinicalTrials.gov registry entry for NCT06973187 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 500 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 2 interventions — of which BGB-16673 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06973187 reports 20 study locations spanning 13 distinct geographic areas — top geographies include California, Florida, Louisiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06973187 about?

NCT06973187 is a clinical study titled "A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma". The purpose of this study is to evaluate the efficacy and safety of BGB-16673 alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had been previously treated with a covalent Bruton tyrosine kinase ...

What is the current status of trial NCT06973187?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 500 participants. The study started on 2025-09-04. Estimated completion is 2028-04-17.

What conditions does trial NCT06973187 study?

This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06973187?

The interventions under investigation include: BGB-16673 (DRUG), Pirtobrutinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06973187?

This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06973187 being conducted?

This trial has 20 study locations across Arizona, California, Delaware, Florida, Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial