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ClinicalTrials.gov 6 recruiting now official registry

Cardiac Surgery clinical trials

6 of 20 indexed Cardiac Surgery trials are currently recruiting.

20 US clinical trials · 6 currently recruiting

Cardiac Surgery is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Los Angeles, running 2 of these trials.

The research picture

Cardiac Surgery has 20 registered US clinical trials, 6 of them open to new participants right now, about 30% of the total.

6
recruiting participants now
30%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
2
top sponsor: University of California, Los Angeles
Phase 12Phase 21Phase 33Phase 43

Active & Recent Trials

20 total, page 1 of 1

RECRUITING Phase 3 3,650 participants

Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass

Xijing Hospital

NCT06702553

RECRUITING NA 1,440 participants

Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

Unity Health Toronto

NCT04754022

RECRUITING 150 participants

Cardiopulmonary Bypass Induced Red Blood Cell Lysis

University of Maryland, Baltimore

NCT05189262

RECRUITING 150 participants

Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Brigham and Women's Hospital

NCT04880265

RECRUITING Phase 4 100 participants

Oral Methadone in Cardiac Surgery

Mayo Clinic

NCT07221617

RECRUITING Early Phase 1 40 participants

Pilot Study Evaluating the Advantages of Sucrosomial® Iron Post-operative Supplementation vs Standard of Care After Cardiac Surgery

Englewood Hospital and Medical Center

NCT06970925

ACTIVE NOT RECRUITING NA 5,502 participants

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

The Cleveland Clinic

NCT04978636

ACTIVE NOT RECRUITING Early Phase 1 225 participants

ESP/PIF for Sternotomy

Icahn School of Medicine at Mount Sinai

NCT04985500

ACTIVE NOT RECRUITING Phase 4 200 participants

Ketamine and Kidney Injury in Cardiac Surgery

Mayo Clinic

NCT05268562

ACTIVE NOT RECRUITING NA 120 participants

A Randomized Clinical Trial to Measure Efficacy of Music on Cardiac Surgery Patients

Massachusetts General Hospital

NCT04551469

COMPLETED Phase 3 1,502 participants

Safety and Efficacy of an Antibiotic Implant in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Infection

Innocoll

NCT00600483

COMPLETED 390 participants

Impact of Blood Storage Duration on Physiologic Measures

Duke University

NCT01274390

COMPLETED NA 250 participants

Remote Ischemic Preconditioning in Cardiac Surgery Trial

McMaster University

NCT01071265

COMPLETED 147 participants

Management of Antiplatelet Regimen During Surgical Procedures

Baylor Research Institute

NCT03981835

COMPLETED 100 participants

Effects of a Hybrid Model of Cardiac Rehabilitation on Patient Outcomes

Good Shepherd Integrated Healthcare Systems

NCT06030115

COMPLETED Phase 3 63 participants

Acute Normovolemic Hemodilution in Complex Cardiac Surgery

University of California, Los Angeles

NCT05049590

COMPLETED 49 participants

Comparison Endotracheal Cardiac Output Monitor (ECOM) to a Standard Device in Measuring Heart Blood Volume

University of California, Los Angeles

NCT00883857

COMPLETED 46 participants

CNAP™ Monitor Study

Nationwide Children's Hospital

NCT01356082

COMPLETED Phase 4 25 participants

Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation

Hartford Hospital

NCT00519337

COMPLETED Phase 2 17 participants

RECOVER I Impella RECOVER LP/LD 5.0 Support System Safety and Feasibility Study

Abiomed

NCT00596726

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 1
Phase 3 3
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cardiac Surgery Trial Landscape

20 indexed Cardiac Surgery studies · 6 recruiting (30%).

Phase mix: 6 late (III/IV) vs 3 early (I/II).

Top sponsor: University of California, Los Angeles (2 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cardiac Surgery?

PlainTrial tracks 20 US clinical trials for Cardiac Surgery, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cardiac Surgery?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.