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ClinicalTrials.gov 6 recruiting now later-stage tilt

Cardiac Surgery: later-stage trial registry

6 of 20 indexed Cardiac Surgery trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #848 of 28,707 conditions by registered trial count.

20 US clinical trials · 6 currently recruiting · #848 of 28,707 conditions by registered trial count

Cardiac Surgery: 20 US clinical trials tracked, 6 recruiting.

Cardiac Surgery is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 6 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, Los Angeles, running 2 of these trials.

Enrollment posture brief

Registry condition cardiac-surgery

OPEN 6 | RECR 30% | LATE 6 | EARLY 3 | RANK #848 | SPON 2

Nearest open-share peer: Adrenocortical Carcinoma (30% recruiting · 10 trials)

Advanced or Metastatic Solid55%ALS50%Cardiac Surgery (this)30%Abdominal Pain25%Acute Myocardial Infarction25%
Open-enrollment share among volume-matched conditions near Cardiac Surgery

Cardiac Surgery lists 6 open slots (30% of 20 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Cardiac Surgery on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Cardiac Surgery is recruiting below its size-band peers.

    6 of 20 indexed trials (30%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Cardiac Surgery trials is spread across many organizations.

    University of California, Los Angeles accounts for 2 of 20 trials (10%). 18 distinct sponsors appear on at least one study for this condition label.

  3. Typical Cardiac Surgery enrolment sits around 150 participants.

    Median target enrolment is 150 among the 20 trials that report a genuine target (sentinel values excluded). 6 of those (30%) plan for fewer than 100 participants.

  4. Cardiac Surgery splits between interventional and observational designs.

    13 interventional and 7 observational studies make up this index (65% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 12Phase 21Phase 33Phase 43

Open and recent trials

20 total, page 1 of 1

RECRUITING Phase 3 3,650 participants

Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass

Xijing Hospital

NCT06702553

RECRUITING NA 1,440 participants

Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

Unity Health Toronto

NCT04754022

RECRUITING 150 participants

Cardiopulmonary Bypass Induced Red Blood Cell Lysis

University of Maryland, Baltimore

NCT05189262

RECRUITING 150 participants

Assessing the Burden of Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery

Brigham and Women's Hospital

NCT04880265

RECRUITING Phase 4 100 participants

Oral Methadone in Cardiac Surgery

Mayo Clinic

NCT07221617

RECRUITING Early Phase 1 40 participants

Pilot Study Evaluating the Advantages of Sucrosomial® Iron Post-operative Supplementation vs Standard of Care After Cardiac Surgery

Englewood Hospital and Medical Center

NCT06970925

ACTIVE NOT RECRUITING NA 5,502 participants

Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)

The Cleveland Clinic

NCT04978636

ACTIVE NOT RECRUITING Early Phase 1 225 participants

ESP/PIF for Sternotomy

Icahn School of Medicine at Mount Sinai

NCT04985500

ACTIVE NOT RECRUITING Phase 4 200 participants

Ketamine and Kidney Injury in Cardiac Surgery

Mayo Clinic

NCT05268562

ACTIVE NOT RECRUITING NA 120 participants

A Randomized Clinical Trial to Measure Efficacy of Music on Cardiac Surgery Patients

Massachusetts General Hospital

NCT04551469

COMPLETED Phase 3 1,502 participants

Safety and Efficacy of an Antibiotic Implant in Cardiac Surgical Subjects at Higher Risk for Sternal Wound Infection

Innocoll

NCT00600483

COMPLETED 390 participants

Impact of Blood Storage Duration on Physiologic Measures

Duke University

NCT01274390

COMPLETED NA 250 participants

Remote Ischemic Preconditioning in Cardiac Surgery Trial

McMaster University

NCT01071265

COMPLETED 147 participants

Management of Antiplatelet Regimen During Surgical Procedures

Baylor Research Institute

NCT03981835

COMPLETED 100 participants

Effects of a Hybrid Model of Cardiac Rehabilitation on Patient Outcomes

Good Shepherd Integrated Healthcare Systems

NCT06030115

COMPLETED Phase 3 63 participants

Acute Normovolemic Hemodilution in Complex Cardiac Surgery

University of California, Los Angeles

NCT05049590

COMPLETED 49 participants

Comparison Endotracheal Cardiac Output Monitor (ECOM) to a Standard Device in Measuring Heart Blood Volume

University of California, Los Angeles

NCT00883857

COMPLETED 46 participants

CNAP™ Monitor Study

Nationwide Children's Hospital

NCT01356082

COMPLETED Phase 4 25 participants

Impact of Ascorbic Acid on Post-Cardiothoracic Surgery Inflammation

Hartford Hospital

NCT00519337

COMPLETED Phase 2 17 participants

RECOVER I Impella RECOVER LP/LD 5.0 Support System Safety and Feasibility Study

Abiomed

NCT00596726

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 1
Phase 3 3
Phase 4 3

Named interventions

Most-linked intervention names on Cardiac Surgery records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

CNAP Device
1 trials
gentamicin-collagen sponge dipped in saline Drug
1 trials
Impella Lp/ld 5.0 Device
1 trials
Exercise Component Of Cardiac Rehabilitation (Hybrid Model) Intensity Recovery Progression Protocol (IRPP) Other
1 trials
Acute normovolemic hemodilution (ANH) Biological
1 trials
Remote Ischemic Preconditioning Procedure
1 trials
music Behavioral
1 trials
Apnea During CPB Other
1 trials

US sites by state

Facility locations filed on Cardiac Surgery trials. A trial with sites in several states counts in each.

Massachusetts 6 trials
New York 3 trials
New Jersey 3 trials
Minnesota 3 trials
Maryland 3 trials
California 3 trials
Texas 2 trials
Pennsylvania 2 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Cardiac Surgery page

20 registered trials, 6 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Cardiac Surgery condition card totals 20 registered trials; most-linked intervention CNAP; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.