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ClinicalTrials.gov 11 recruiting now official registry

Advanced or Metastatic Solid Tumors clinical trials

11 of 20 indexed Advanced or Metastatic Solid Tumors trials are currently recruiting.

20 US clinical trials · 11 currently recruiting

Advanced or Metastatic Solid Tumors is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is Erasca, running 3 of these trials.

The research picture

Advanced or Metastatic Solid Tumors has 20 registered US clinical trials, 11 of them open to new participants right now, about 55% of the total.

11
recruiting participants now
55%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
3
top sponsor: Erasca
Phase 120

Active & Recent Trials

20 total, page 1 of 1

RECRUITING Phase 1 320 participants

DCSZ11 as a Monotherapy and in Combination in Patients With Advanced or Metastatic Solid Tumors

DynamiCure Biotechnology

NCT05785754

RECRUITING Phase 1 292 participants

Dose Escalation and Expansion Study of HM16390 Alone or With Pembrolizumab in Advanced or Metastatic Solid Tumors

Hanmi Pharmaceutical Company Limited

NCT06724016

RECRUITING Phase 1 270 participants

A First-in-human Study of PRTH-101 Monotherapy +/- Pembrolizumab in Subjects With Advanced Malignancies

Incendia Therapeutics

NCT05753722

RECRUITING Phase 1 254 participants

To Evaluate the Safety, Tolerability, Pharmacokinetics and Antitumor Activity of DAY301 in Participants With Locally Advanced or Metastatic Solid Tumors

Day One Biopharmaceuticals

NCT06752681

RECRUITING Phase 1 245 participants

Dose Escalation and Expansion Study of BH3120 Alone or With Pembrolizuamb in Advanced or Metastatic Solid Tumors

Hanmi Pharmaceutical Company Limited

NCT06234397

RECRUITING Phase 1 223 participants

A Study of TAK-188 in Adults With Advanced or Spreading Solid Tumors

Takeda

NCT07205718

RECRUITING Phase 1 216 participants

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

IDEAYA Biosciences

NCT05787587

RECRUITING Phase 1 145 participants

Safety and Tolerability of IPH4502 in Patients With Advanced Solid Tumors

Innate Pharma

NCT06781983

RECRUITING Phase 1 145 participants

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

NextCure

NCT06774963

RECRUITING Phase 1 124 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Pfizer

NCT05538130

RECRUITING Phase 1 120 participants

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies

858 Therapeutics

NCT06395519

ACTIVE NOT RECRUITING Phase 1 200 participants

A Dose Escalation/Expansion Study of ERAS-601 in Patients With Advanced or Metastatic Solid Tumors

Erasca

NCT04670679

ACTIVE NOT RECRUITING Phase 1 200 participants

A Study of ERAS-007 as Monotherapy or in Combination With ERAS-601 in Patients With Advanced or Metastatic Solid Tumors

Erasca

NCT04866134

ACTIVE NOT RECRUITING Phase 1 100 participants

A Phase 1b/2 Multisite Dose-finding and Expansion Study of WTX-330 in Adult Patients With Selected Advanced or Metastatic Solid Tumors or Lymphoma

Werewolf Therapeutics

NCT06939283

ACTIVE NOT RECRUITING Phase 1 97 participants

A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Participants with Advanced Unresectable or Metastatic Solid Tumors

NextCure

NCT05572684

ACTIVE NOT RECRUITING Phase 1 86 participants

A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With RAS Q61X Mutations

Erasca

NCT05907304

ACTIVE NOT RECRUITING Phase 1 72 participants

A Dose Escalation and Expansion Study of TAC-001 in Patients With Select Advanced or Metastatic Solid Tumors

Tallac Therapeutics

NCT05399654

ACTIVE NOT RECRUITING Phase 1 70 participants

A Study of MK-1484 as Monotherapy and in Combination With Pembrolizumab (MK-3475) In Advanced or Metastatic Solid Tumors (MK-1484-001)

Merck Sharp & Dohme

NCT05382325

COMPLETED Phase 1 1,163 participants

A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors

Bristol-Myers Squibb

NCT01928394

COMPLETED Phase 1 161 participants

A Study of TAK-981 Given With Pembrolizumab in Participants With Select Advanced or Metastatic Solid Tumors

Takeda

NCT04381650

Phase Distribution

PhaseTrial count
Phase 1 20

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced or Metastatic Solid Tumors Trial Landscape

20 indexed Advanced or Metastatic Solid Tumors studies · 11 recruiting (55%).

Phase mix: 0 late (III/IV) vs 20 early (I/II).

Top sponsor: Erasca (3 trials), 9 others listed. 20 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced or Metastatic Solid Tumors?

PlainTrial tracks 20 US clinical trials for Advanced or Metastatic Solid Tumors, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced or Metastatic Solid Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.